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Phosphodiesterase-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphodiesterase (PDE) (42) Apoptosis (3) Biochemical Assay Reagents (1) Calcium Channel (2) DNA/RNA Synthesis (2) Fungal (1) Histone Methyltransferase (3) Interleukin Related (2) NO Synthase (2) NTPDase (1) p38 MAPK (1) Parasite (4) Phosphatase (2) PKA (4) Reactive Oxygen Species (ROS) (4) Reference Standards (2) STING (1) TGF-beta/Smad (1) Topoisomerase (1) Tyrosinase (1)
By Research Areas:	Cancer (28) Infection (9) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (6)

Inhibitors & Agonists

Peptides

Natural
Products

Protéines recombinantes

Antibodies

Targets Recommended: Phosphodiesterase (PDE)

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-134124

Glutathione ethyl ester	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense ^[1].

HY-100530D

Rp-cAMPS sodium salt 5 Publications Verification	PKA	Neurological Disease
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases .

HY-129490

Enpp-1-IN-1 3 Publications Verification	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-1 is an effective selective *enpp-1* (nucleotide pyrophosphatase-phosphodiesterase 1) inhibitor ^[1].

HY-110137

Furamidine dihydrochloride 3 Publications Verification DB75 dihydrochloride; NSC 305831 dihydrochloride	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine dihydrochloride is selective for *PRMT1* over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of *TDP-1* by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent ^[1] .

HY-147389

Enpp-1-IN-14 1 Publications Verification	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC₅₀ value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity ^[1].

HY-143256

Enpp-1-IN-12	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity ^[1].

HY-119372

TDP1 Inhibitor-1	Phosphodiesterase (PDE)	Cancer
TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC₅₀ of 7 μM. TDP1 Inhibitor-1 shows cytotoxicity against multiple cancer cells. TDP1 Inhibitor-1 can be used for the research of cancer, such as breast cancer ^[1].

HY-161853

TX-2552	Phosphodiesterase (PDE)	Others
TX-2552 is an orally active tyrosine DNA phosphodiesterase 1 (TDP1) inhibitor with an IC₅₀ value of 0.62 μM. TX-2552 can enhance the clastogenic activity of Topotecan (HY-13768) in mouse bone marrow cells, as well as the anti-tumor effect of Topotecan (HY-13768) in Krebs-2 ascites tumor mice ^[1] .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection ^[1].

HY-136569

DSR-141562	Phosphodiesterase (PDE)	Neurological Disease
DSR-141562 is a novel, orally active, and selective brain-penetrant **phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC₅₀ of 43.9 nM, and the IC₅₀** values for human PDE1A and 1C are 97.6 and 431.8 nM, respectively. DSR-141562 can be used for the study of positive symptoms, negative symptoms and cognitive impairments associated with schizophrenia ^[1] .

HY-163343

Enpp-1-IN-20	Phosphodiesterase (PDE) STING	Cancer
Enpp-1-IN-20 (Compound 31) is an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor, with an IC₅₀ of 0.09 nM. Enpp-1-IN-20 has strongest inhibitory activity in the cell-based assay, with an IC₅₀ of 8.8 nM. Enpp-1-IN-20 has significant potency in both ENPP1 inhibition and STING pathway stimulation in vitro. Enpp-1-IN-20 can be used for the research of cancer ^[1].

HY-158791

Enpp-1-IN-21	Phosphodiesterase (PDE)	Metabolic Disease Cancer
Enpp-1-IN-21 (compound 4g) is an inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), with IC₅₀ values for *ENPP1* and ENPP3 at 0.45 and 0.19 μM, respectively ^[1].

HY-143254

Enpp-1-IN-10	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-10 (compound 1) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an K_i value of 3.866 μM. Enpp-1-IN-10 can be used for researching anticancer ^[1].

HY-N7272

Cirsimarin	Phosphodiesterase (PDE)	Metabolic Disease
Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on *phosphodiesterase* .

HY-139362

Enpp-1-IN-2	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-2 (Compound C) is a potent *ENPP1* (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC₅₀ values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green)-mAMP: a newly synthesized sensitive ENPP1 fluorescence probe ^[1].

HY-100530A

Rp-cAMPS	PKA	Neurological Disease
Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases .

HY-100530

Rp-cAMPS triethylammonium salt 5 Publications Verification	PKA	Neurological Disease
Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases .

HY-143255

Enpp-1-IN-11	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-11 (compound 23) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an K_i value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer ^[1].

HY-169402A

PDE1-IN-9 hydrochloride	Phosphodiesterase (PDE) NO Synthase Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
PDE1-IN-9 (Compound 7a) hydrochloride is a selective inhibitor for *phosphodiesterase 1* (PDE1), that inhibits *PDE1C* with an IC₅₀ of 11 nM. PDE1-IN-9 hydrochloride reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 hydrochloride exhibits good metabolic stability in rat liver microsomes ^[1].

HY-110137A

Furamidine DB75; NSC 305831	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine (DB75) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine is selective for *PRMT1* over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of *TDP-1* by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent ^[1] .

HY-120798

4-Nitrophenyl phenylphosphonate	Phosphodiesterase (PDE)	Others
4-Nitrophenyl phenylphosphonate is a substrate for 5'-nucleotide phosphodiesterase .

HY-153334

Enpp-1-IN-15	Phosphodiesterase (PDE)	Others
Enpp-1-IN-15 (Compound 88a) is an Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (Enpp-1) Inhibitor, with a K_i value of 0.00586 nM ^[1].

HY-147750

TDP1 Inhibitor-2	Phosphodiesterase (PDE)	Neurological Disease Cancer
TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for *TDP1* (tyrosyl-DNA phosphodiesterase 1), with an IC₅₀ of 99 nM. TDP1 Inhibitor-2 also can inhibit *SCAN1* (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC₅₀ of 3.5 μM ^[1].

HY-N2913

Ayanin	Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Ayanin is a bioflavonoid isolated from Psychotria serpens. Ayanin is a non-selective *phosphodiesterase_1-4* inhibitor and can be used for the study of respiratory disease,such as allergic asthma et al ^[1].

HY-P2424

Cholecystokinin-J CCK-J	Calcium Channel	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release ^[1].

HY-N8209

(+)-Medioresinol Di-O-β-D-glucopyranoside	Phosphodiesterase (PDE)	Inflammation/Immunology
(+)-Medioresinol Di-O-β-D-glucopyranoside is a lignan glucoside with strong inhibitory activity of 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase .

HY-N1289

Sequosempervirin B	Fungal Phosphodiesterase (PDE)	Infection
Sequosempervirin B, a norlignan isolated from the branches and leaves of Sequoia sempervirens, has antifungal properties. Sequosempervirin B has an inhibitory effect on cyclic AMP phosphodiesterase .

HY-N2658

5,7-Diacetoxy-8-methoxyflavone	Phosphodiesterase (PDE)	Others
5,7-Diacetoxy-8-methoxyflavone is a natural product that could come from scutellaria genus plants. 5,7-Diacetoxy-8-methoxyflavone has inhibitory activity for cAMP phosphodiesterase .

HY-176874

Enpp-1-IN-29	Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Enpp-1-IN-29 (Compound 1) is a highly selective ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor (IC₅₀=0.05 nM). Enpp-1-IN-29 is promising for research of ENPP1-overexpressing cancers (e.g., breast cancer, head/neck cancer, metastatic chromosome-unstable tumors) and immune-related diseases (e.g., autoimmune disorders, tumor immune evasion) ^[1].

HY-147946

PDE1-IN-4	Phosphodiesterase (PDE) Calcium Channel	Inflammation/Immunology
PDE1-IN-4 (compound 2g) is a potent and selective *PDE1* (phosphodiesterase-1) inhibitor, with IC₅₀ values of 10, 145, and 354 nM for *PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4* inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research ^[1].

HY-163406

PDE1-IN-6	Phosphatase Apoptosis	Cancer
PDE1-IN-6 (compound 6c) is a selectivity *PDE1* inhibitor with the IC₅₀ of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells ^[1].

HY-U00374

Sch59498	Phosphodiesterase (PDE)	Neurological Disease
Sch59498 is a potent inhibitor of **phosphodiesterase 1c (Pde1c)**.

HY-176409

Phosphodiesterase-IN-4	Phosphodiesterase (PDE)	Cancer
Phosphodiesterase-IN-4 (compound 18) is a potent Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor. Phosphodiesterase-IN-4 inhibits colorectal cancer cells with an IC₅₀ of 6.9 μM ^[1].

HY-134302

8-HA-cAMP 8-Hexylamino-cAMP	PKA	Others
8-HA-cAMP is a membrane-permeable cAMP analogue and an activator of cAMP-dependent protein kinase and PKA I. 8-HA-cAMP exerts metabolic stability towards mammalian cyclic nucleotide-responsive phosphodiesterases .

HY-163448

NPP1-IN-2	Phosphatase	Cancer
NPP1-IN-2 (compound 3h) is a potent and selective Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) inhibitor with IC₅₀ values of 0.55, 3.73 µM for NPP1, NPP3, respectively ^[1].

HY-145062

Enpp-1-IN-4	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-4 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). Enpp-1-IN-4 has the potential for the research of cancer diseases (extracted from patent WO2019177971A1, compound 1) ^[1].

HY-130262

PDE1-IN-3	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE1-IN-3, compound 4 (WO2019156861), is a selective human **phosphodiesterase 1 (PDE1)** inhibitor. PDE1-IN-3 inhibits PDE4D and PDE6AB with IC₅₀ values of 23.99 μM and 10 μM, respectively ^[1].

HY-175971

PDE1-IN-10	Phosphodiesterase (PDE) TGF-beta/Smad p38 MAPK	Inflammation/Immunology
PDE1-IN-10 is a potent and sekective *Phosphodiesterase 1* (PDE1) inhibitor with an IC₅₀ of 5 nM. PDE1-IN-10 can suppress TGF-β/Smad-MAPK signaling and exhibit antifibrotic effects. PDE1-IN-10 can be used for the research of idiopathic pulmonary fibrosis ^[1].

HY-N7272R

Cirsimarin (Standard)	Reference Standards Phosphodiesterase (PDE)	Metabolic Disease
Cirsimarin (Standard) is the analytical standard of Cirsimarin. This product is intended for research and analytical applications. Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase .

HY-145064

Enpp-1-IN-6	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-6 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-6 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) ^[1].

HY-145070

Enpp-1-IN-9	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-9 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-9 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) ^[1].

HY-145065

Enpp-1-IN-7	Phosphodiesterase (PDE)	Infection Cancer
Enpp-1-IN-7 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-7 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) ^[1].

HY-145069

Enpp-1-IN-8	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-8 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-8 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51) ^[1].

HY-169402

PDE1-IN-9	Phosphodiesterase (PDE) NO Synthase Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
PDE1-IN-9 (Compound 7a) is a selective inhibitor for *phosphodiesterase 1* (PDE1), that inhibits *PDE1C* with an IC₅₀ of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes ^[1].

HY-141555

5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione	Phosphodiesterase (PDE) Tyrosinase	Others
5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant *phosphodiesterase 1* with IC₅₀ of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with K_i of 1.9 μM ^[1] .

HY-145063

Enpp-1-IN-5	Phosphodiesterase (PDE)	Infection Inflammation/Immunology Cancer
Enpp-1-IN-5 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-5 has the potential for the research of cancer and infectious diseases (extracted from patent WO2019046778A1/WO2021203772A1, compound 1) ^[1] .

HY-175779

TDP1-IN-4	Phosphodiesterase (PDE)	Cancer
TDP1-IN-4 (Compound 33) is a Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC₅₀ of 0.90  μM. TDP1-IN-4 has a strong synergistic effect with Camptothecin (HY-16560) in SK-Mel-2 cells, but not in cancer cells (A549, HCT-116 and MCF-7 cells) and non-cancerous Ges-1 cells. TDP1-IN-4 can be used for cancer chemotherapy and radiotherapy research ^[1].

HY-110137R

Furamidine dihydrochloride (Standard) DB75 dihydrochloride (Standard); NSC 305831 dihydrochloride (Standard)	Histone Methyltransferase Phosphodiesterase (PDE) Parasite Reference Standards	Infection Inflammation/Immunology Cancer
Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride). This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent ^[1] .

HY-177991

Cylic-DAP	Biochemical Assay Reagents	Others
Cylic-DAP is a substrate of splenic cyclic phosphodiesterases .

HY-183334

TDP1-IN-5	Phosphodiesterase (PDE) Reactive Oxygen Species (ROS) DNA/RNA Synthesis Apoptosis	Cancer
TDP1-IN-5 is a tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC₅₀ of 2.2 μM. By targeting TDP1 both intracellularly and extracellularly, TDP1-IN-5 inhibits the NHEJ repair pathway, arrests the cell cycle at the G2/M phase, upregulates PIG3 to enhance ROS, and ultimately significantly potentiates ionizing radiation (IR)-induced DNA damage and apoptosis. TDP1-IN-5 can be used in the research of colorectal cancer ^[1].

Cat. No.	Nom du produit	Target	Research Area

HY-134124

Glutathione ethyl ester	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense ^[1].

HY-P2424

Cholecystokinin-J CCK-J	Calcium Channel	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release ^[1].

Cat. No.	Compare	Nom du produit	Species	Source	Image

HY-P75960

	PDE1B Protein, Human (sf9, His-GST) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide Phosphodiesterase 1B; Cam-PDE 1B; PDE1B1; PDES1B	Human	Sf9 insect cells
	PDE1B protein, a cyclic nucleotide phosphodiesterase, displays dual specificity for cAMP and cGMP, essential second messengers in physiological processes. Preferring cGMP as a substrate, PDE1B fine-tunes cellular responses to cyclic nucleotide signaling. Its dual specificity underscores its regulatory role in diverse physiological pathways. PDE1B Protein, Human (sf9, His-GST) is the recombinant human-derived PDE1B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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HY-P87203

	ENPP1/PC1 Antibody (YA6891) Alkaline Phosphodiesterase 1 antibody	WB, IHC-P	Human
	ENPP1/PC1 Antibody (YA6891) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ENPP1/PC1.

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Phosphodiesterase-1

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