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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Plasmodium falciparum 3D7 parasites
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Plasmodium falciparum 3D7 parasites" in MCE Product Catalog:
Cat. No.: HY-151574
CAS No.: 2797225-49-9
Target:
Research Areas:
PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research .
Research Areas:
MMV009085 is a potent PfHT1 (Plasmodium falciparum hexose transporter)-specific inhibitor and a potential anti-malarial agent . MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC50: 2.6 μM in glucose uptake assay) and growth of the parasites (EC50: 1.23±0.04 μM against 3D7) .
Cat. No.: HY-N8513
CAS No.: 215121-47-4
Target:
Cat. No.: HY-189416
Target:
Research Areas:
Antimalarial agent-71 is an antimalarial agent and antioxidant. Antimalarial agent-71 is computationally predicted to bind within the PfNDH2 binding pocket, which is located on the type II NADH dehydrogenase of the mitochondrial electron transport chain. Antimalarial agent-71 inhibits the growth of Plasmodium falciparum 3D7 parasites in whole-cell assays. Antimalarial agent-71 scavenges DPPH free radicals. Antimalarial agent-71 can be used in research on malaria and antioxidation .
Cat. No.: HY-181010
HDAC1-IN-12 is a Plasmodium falciparum HDAC1 (PfHDAC1) inhibitor with an IC50 of 4.1 nM against Pf3D7. HDAC1-IN-12 inhibits PfHDAC1, upregulates histone H3 acetylation in P. falciparum parasites, downregulates malaria invasion-related gene expression, and exhibits favorable safety profiles, improved physicochemical properties, and potent in vivo antimalarial activity. HDAC1-IN-12 can be used for the research of malaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
