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Cat. No.: HY-189416

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Antimalarial agent-71

Antimalarial agent-71 is an antimalarial agent and antioxidant. Antimalarial agent-71 is computationally predicted to bind within the PfNDH2 binding pocket, which is located on the type II NADH dehydrogenase of the mitochondrial electron transport chain. Antimalarial agent-71 inhibits the growth of Plasmodium falciparum 3D7 parasites in whole-cell assays. Antimalarial agent-71 scavenges DPPH free radicals. Antimalarial agent-71 can be used in research on malaria and antioxidation.

For research use only. We do not sell to patients.

Formula: C₁₆H₉F₃N₂O₂
Molecular Weight:318.25

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Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent-71 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

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In Vitro

Antimalarial agent-71 (PPA3) exhibits the highest antiplasmodial activity among the synthesized chromene derivatives against the Chloroquine (HY-17589A)-sensitive Plasmodium falciparum 3D7 strain, with an IC₅₀ of 0.62 μg/mL (≈1.01 μM)^[1].
Antimalarial agent-71 exhibits the strongest antioxidant activity among the synthesized chromene derivatives in the DPPH radical scavenging assay, with an IC₅₀ of 17.6 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

Molecular Weight 318.25
Formula C₁₆H₉F₃N₂O₂
SMILES

OC1=CC2=C(C=C1)C(C3=CC(F)=C(F)C(F)=C3)C(C#N)=C(N)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Patil P, et al. Vitamin B-catalyzed green synthesis and antiplasmodial evaluation of 2-amino-7-hydroxy-4-aryl-4-chromene-3-carbonitrile derivatives: computational insights into putative PfNDH2 targeting. RSC advances. 2026 Sep 16;16(41):48388-48415.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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