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Protox

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endogenous Metabolite (1) Environmental Pollutants (2) Herbicide (6) Protoporphyrinogen IX oxidase (1) Reference Standards (1)
By Research Areas:	Cancer (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128075

Acifluorfen	Environmental Pollutants Herbicide	Cancer
Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species .

HY-147365

Acifluorfen-methyl	Environmental Pollutants Herbicide	Others
Acifluorfen-methyl is an inhibitor of the heme and chlorophyll biosynthetic enzyme protoporphyrinogen oxidase (Protox). Acifluorfen-methyl is a photobleaching herbicide .

HY-118085

Fluazolate Isopropazol; JV-485	Herbicide	Others
Fluazolate is a herbicide that inhibits protoporphyrinogen-IX-oxidase (Protox) and targets glyphosate-resistant weeds . .

HY-118985

Acifluorfen sodium	Endogenous Metabolite	Cancer
Acifluorfen sodium, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen sodium causes strong photooxidative destruction of pigments and lipids in sensitive plant species .

HY-128075R

Acifluorfen (Standard)	Herbicide Reference Standards	Cancer
Acifluorfen (Standard) is the analytical standard of Acifluorfen. This product is intended for research and analytical applications. Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species .

HY-W747529

Fluthiacet-methyl	Herbicide	Others
Fluthiacet-methyl is an isoxazole herbicide and also a protoporphyrinogen oxidase (Protox) inhibitor. Fluthiacet-methyl inhibits chlorophyll biosynthesis in cotyledons of velvetleaf and cotton. Fluthiacet-methyl induces electrolyte leakage in cotyledons of sensitive plants such as velvetleaf and cotton. Fluthiacet-methyl induces the accumulation of protoporphyrin IX in cotton cotyledons .

HY-W351546

Carfentrazone-ethyl	Herbicide Protoporphyrinogen IX oxidase	Others
Carfentrazone-ethyl is a selective post-emergence herbicide and protoporphyrinogen oxidase (Protox) inhibitor, with an I₅₀ value of 18 nM against soybean Protox. Carfentrazone-ethyl causes severe damage to target weeds (ivy-leaved morning glory, velvetleaf) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Protox

Inhibitors & Agonists