![5,7-Dichloropyrazolo[1,5-a]pyrimidine](https://file.medchemexpress.com/product_pic/hy-w003486.gif "Click to View 5,7-Dichloropyrazolo[1,5-a]pyrimidine Product Detail")
![tert-Butyl (S)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-3-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate](https://file.medchemexpress.com/product_pic/hy-48099.gif "Click to View tert-Butyl (S)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-3-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate Product Detail")
![5-Bromo-1H-pyrazolo[3,4-b]pyridine](https://file.medchemexpress.com/product_pic/hy-69077.gif "Click to View 5-Bromo-1H-pyrazolo[3,4-b]pyridine Product Detail")
![(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-42697.gif "Click to View (R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate Product Detail")
![(R)-tert-Butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate](https://file.medchemexpress.com/product_pic/hy-43029.gif "Click to View (R)-tert-Butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Product Detail")
![1-(4-Chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide](https://file.medchemexpress.com/product_pic/hy-i0462.gif "Click to View 1-(4-Chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide Product Detail")
![1-Methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one](https://file.medchemexpress.com/product_pic/hy-w052249.gif "Click to View 1-Methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Product Detail")
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![6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine](https://file.medchemexpress.com/product_pic/hy-152438.gif "Click to View 6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
Pyrazolo
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "Pyrazolo" in MCE Product Catalog:
3
3 Cited Publications
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.
Cat. No.: HY-W003486
CAS No.: 57489-77-7
Target:
Research Areas:
5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a Ki of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia .
Cat. No.: HY-48099
CAS No.: 2212021-61-7
Target:
Research Areas:
tert-Butyl (S)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-3-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-69077
CAS No.: 875781-17-2
Cat. No.: HY-42697
CAS No.: 2135871-21-3
Target:
Research Areas:
(R)-Phenyl (5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)carbamate is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-43029
CAS No.: 1276110-38-3
Target:
Research Areas:
(R)-tert-Butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-I0462
CAS No.: 2029205-64-7
Target:
Research Areas:
1-(4-Chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide is a drug intermediate for synthesis of various active compounds.
Research Areas:
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation .
Efflux inhibitor-1 (compound 2) is a pyrazolo[1,5-a]pyrimidine efflux inhibitor. Efflux inhibitor-1 selectively targets toward ABCG2/BCRP over ABCB1 with IC50s of 0.45 μM and 2.17 μM, respectively .
Cat. No.: HY-W052249
CAS No.: 5334-56-5
Cat. No.: HY-W002060
CAS No.: 21901-40-6
Synonyms: 2-Amino-5-nitro-4-picoline
Cat. No.: HY-121682
CAS No.: 61788-27-0
Target:
Research Areas:
N-(2-Chlorophenyl)-1H-indole-3-carboxamide (Compound 60) is a substituted derivative of the pyrazolo[1,5-a]pyridine core. N-(2-Chlorophenyl)-1H-indole-3-carboxamide does not exhibit EphB3 kinase inhibitory activity and can be used as a negative control compound .
Cat. No.: HY-W000643
CAS No.: 271-73-8
Cat. No.: HY-174414
EGFR/HER2-IN-18 is a stable EGFR/HER2 dual inhibitor with IC50 values of 0.09 (EGFR) and 0.08 μM (HER2) respectively. EGFR/HER2-IN-18 exhibits broad-spectrum anti-cancer activity. EGFR/HER2-IN-18 induces MCF-7 cells apoptosis and inhibits the cell cycle. EGFR/HER2-IN-18 can be used for the study of breast cancer .
Cat. No.: HY-148832
CAS No.: 1581714-50-2
Target:
Research Areas:
BTK-IN-20 (compound 283) is a BTK tyrosine kinase inhibitor and a 1H-pyrazolo[3,4-d]pyrimidine derivative. BTK-IN-20 can be used for the research of cancer and inflammation .
Cat. No.: HY-152408
CAS No.: 124137-35-5
Target:
Research Areas:
2-β-D-Ribofuranosyl-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
Cat. No.: HY-152828
CAS No.: 70421-30-6
Target:
Research Areas:
1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
Cat. No.: HY-152438
Target:
Research Areas:
6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc . 6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-152398
Target:
Research Areas:
6-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
