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11 Results for "
RPE65
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "RPE65" in MCE Product Catalog:
Cat. No.: HY-19720A
CAS No.: 1141934-97-5
Synonyms: ACU-4429 hydrochloride
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Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .
Cat. No.: HY-19720
CAS No.: 1141777-14-1
Synonyms: ACU-4429
Target:
Research Areas:
Emixustat is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .
RPE65-IN-1(Compound 16e) is a potent RPE65 inhibitor, with an IC50 value of 0.29 μM. which can be used in retinopathy-related research .
Cat. No.: HY-RS12151
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RPE65 Human Pre-designed siRNA Set A contains three designed siRNAs for RPE65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22780
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Rpe65 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rpe65 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS29294
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Rpe65 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rpe65 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175663
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EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
Cat. No.: HY-175664
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EYE-003 is an orally active RPE65 inhibitor with an IC50 of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4 ⁻/⁻ Rdh8 ⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
Cat. No.: HY-119059
CAS No.: 946249-82-7
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Research Areas:
CU239 is a potent and competitive non-retinoic acid inhibitor of RPE65 with an IC50 for RPE65 isomerase (11-cis retinal) of 6 μM. CCU239 exhibits delayed chromophore regeneration after light bleach, and conferrs a partial protection of the retina against injury from high intensity light. CU239 can be used for the study of retinal degeneration .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
