10 Results for "

RXFP3

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "RXFP3" in MCE Product Catalog:

Cat. No.: HY-150700
CAS No.: 2784577-71-3
Purity:  99.79%
Target:  

ERK

Research Areas:  

Metabolic Disease

RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome .
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Cat. No.: HY-145278
CAS No.: 2752378-78-0
Purity:  99.82%
Target:  

RXFP Receptor

Research Areas:  

Neurological Disease

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM .
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Cat. No.: HY-145279
CAS No.: 2752378-24-6
Target:  

RXFP Receptor

Research Areas:  

Others

RXFP3 agonist 1 is a nonpeptide RXFP3 agonist (EC50=6937 nM) .
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Cat. No.: HY-RS12359
Research Areas:  

Others

RXFP3 Human Pre-designed siRNA Set A contains three designed siRNAs for RXFP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS19034
Research Areas:  

Others

Rxfp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rxfp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-111583
CAS No.: 2351104-40-8
Target:  

RXFP Receptor

Research Areas:  

Metabolic Disease

RXFP3/4 agonist 1 is an agonist of relaxin family peptide 3/4 receptor (RXFP3/4), with EC50s of 82/2 nM, respectivley. RXFP3/4 agonist 1 increases food intake in rats .
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Cat. No.: HY-RS25523
Research Areas:  

Others

Rxfp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rxfp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P10687
Target:  

RXFP Receptor

Research Areas:  

Others

H3B10-27(13/17αF) is an excellent scaffold for further developing reagent candidates and an important tool for understanding the physiological functions of the neuropeptide G protein-coupled receptor RXFP3, and it's very stable in serum .
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Cat. No.: HY-P11246
CAS No.: 3057097-31-8
Target:  

RXFP Receptor

Research Areas:  

Metabolic Disease

A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation .
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Cat. No.: HY-P992108
CAS No.: 3061442-66-5
Synonyms: RELAX10

Research Areas:  

Cardiovascular Disease

Efadirelaxin alfa (RELAX10) is a highly selective agonist of relaxin/insulin-like family peptide receptor RXFP1. After subcutaneous administration in animal experiments, Efadirelaxin alfa exhibits a significantly prolonged terminal half-life (7 days in mice, 3.75 days in rats), and shows no activity against related receptors such as RXFP2 and RXFP3. Efadirelaxin alfa has significant anti-cardiac hypertrophy and anti-fibrotic effects. Efadirelaxin alfa effectively attenuates and reverses cardiac hypertrophy and collagen deposition by regulating the TGF-β1/Smad2 and AKT/eNOS signaling pathways. Efadirelaxin alfa improves cardiac systolic function without causing fluctuations in blood pressure or heart rate, demonstrating favorable safety. Efadirelaxin alfa is currently mainly used in studies related to heart failure .
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