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Isoforms Recommended:	RXFP3

Results for "

RXFP3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RXFP Receptor (6) Akt (1) ERK (1) NO Synthase (1) Small Interfering RNA (siRNA) (3) VEGFR (1)
By Research Areas:	Cardiovascular Disease (1) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Oligonucleotides

Targets Recommended: RXFP Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150700

RLX-33	ERK	Metabolic Disease
RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC₅₀ values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome .

HY-145278

RXFP3/4 agonist 2	RXFP Receptor	Neurological Disease
RXFP3/4 agonist 2 is a potent, nonpeptide dual *RXFP3/4* agonist (EC₅₀=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC₅₀ values in the range of 10-22 nM .

HY-145279

RXFP3 agonist 1	RXFP Receptor	Others
RXFP3 agonist 1 is a nonpeptide *RXFP3* agonist (EC₅₀=6937 nM) .

HY-RS19034

Rxfp3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rxfp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rxfp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rxfp3 Mouse Pre-designed siRNA Set A Rxfp3 Mouse Pre-designed siRNA Set A

HY-RS12359

RXFP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RXFP3 Human Pre-designed siRNA Set A contains three designed siRNAs for RXFP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RXFP3 Human Pre-designed siRNA Set A RXFP3 Human Pre-designed siRNA Set A

HY-111583

RXFP3/4 agonist 1	RXFP Receptor	Metabolic Disease
RXFP3/4 agonist 1 is an agonist of relaxin family peptide 3/4 receptor (RXFP3/4), with EC₅₀s of 82/2 nM, respectivley. RXFP3/4 agonist 1 increases food intake in rats .

HY-RS25523

Rxfp3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rxfp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rxfp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rxfp3 Rat Pre-designed siRNA Set A Rxfp3 Rat Pre-designed siRNA Set A

HY-P10687

H3B10-27(13/17αF)	RXFP Receptor	Others
H3B10-27(13/17αF) is an excellent scaffold for further developing reagent candidates and an important tool for understanding the physiological functions of the neuropeptide G protein-coupled receptor *RXFP3*, and it's very stable in serum .

HY-P11246

A13:B7-24-GG	RXFP Receptor	Metabolic Disease
A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective *RXFP4* agonist with a K_i value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (K_i = 602.56 nM) and an inhibitory effect on cAMP (EC₅₀) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC₅₀ of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation .

HY-P992108

Efadirelaxin alfa RELAX10	RXFP Receptor Akt NO Synthase VEGFR	Cardiovascular Disease
Efadirelaxin alfa (RELAX10) is a highly selective agonist of relaxin/insulin-like family peptide receptor *RXFP1. After subcutaneous administration in animal experiments, Efadirelaxin alfa exhibits a significantly prolonged terminal half-life (7 days in mice, 3.75 days in rats), and shows no activity against related receptors such as RXFP2* and *RXFP3. Efadirelaxin alfa has significant anti-cardiac hypertrophy and anti-fibrotic effects. Efadirelaxin alfa effectively attenuates and reverses cardiac hypertrophy and collagen deposition by regulating the TGF-β1/Smad2* and AKT/eNOS signaling pathways. Efadirelaxin alfa improves cardiac systolic function without causing fluctuations in blood pressure or heart rate, demonstrating favorable safety. Efadirelaxin alfa is currently mainly used in studies related to heart failure .

Cat. No.	Product Name	Target	Research Area

HY-P10687

H3B10-27(13/17αF)	RXFP Receptor	Others
H3B10-27(13/17αF) is an excellent scaffold for further developing reagent candidates and an important tool for understanding the physiological functions of the neuropeptide G protein-coupled receptor *RXFP3*, and it's very stable in serum .

HY-P11246

A13:B7-24-GG	RXFP Receptor	Metabolic Disease
A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective *RXFP4* agonist with a K_i value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (K_i = 602.56 nM) and an inhibitory effect on cAMP (EC₅₀) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC₅₀ of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992108

Efadirelaxin alfa RELAX10	RXFP Receptor Akt NO Synthase VEGFR	Cardiovascular Disease
Efadirelaxin alfa (RELAX10) is a highly selective agonist of relaxin/insulin-like family peptide receptor *RXFP1. After subcutaneous administration in animal experiments, Efadirelaxin alfa exhibits a significantly prolonged terminal half-life (7 days in mice, 3.75 days in rats), and shows no activity against related receptors such as RXFP2* and *RXFP3. Efadirelaxin alfa has significant anti-cardiac hypertrophy and anti-fibrotic effects. Efadirelaxin alfa effectively attenuates and reverses cardiac hypertrophy and collagen deposition by regulating the TGF-β1/Smad2* and AKT/eNOS signaling pathways. Efadirelaxin alfa improves cardiac systolic function without causing fluctuations in blood pressure or heart rate, demonstrating favorable safety. Efadirelaxin alfa is currently mainly used in studies related to heart failure .

Rxfp3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rxfp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rxfp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

RXFP3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RXFP3 Human Pre-designed siRNA Set A contains three designed siRNAs for RXFP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rxfp3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Rxfp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rxfp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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