Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Relb
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Relb" in MCE Product Catalog:
5
5 Cited Publications
Referencia número: HY-P3229
No. CAS: 1071173-56-2
Referencia número: HY-171579
No. CAS: 301655-16-3
Áreas de investigación:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
RS47 is a selective RelB inhibitor with a Kd value of 1.1 μM. RS47 also acts as an inhibitor of HCV replication. RS47 can block the non-canonical NF-κB signaling pathway without affecting the canonical pathway. RS47 exerts anti-tumor effects of inhibiting proliferation and promoting apoptosis on colorectal cancer, B-cell lymphoma and other related tumors both in vitro and in vivo by disrupting the binding of RelB to target DNA. RS47 can be used for the research of tumors and infectious diseases .
Referencia número: HY-RS11829
Target:
Áreas de investigación:
RELB Human Pre-designed siRNA Set A contains three designed siRNAs for RELB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS11830
Target:
Áreas de investigación:
Relb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Relb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS11831
Target:
Áreas de investigación:
Relb Rat Pre-designed siRNA Set A contains three designed siRNAs for Relb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-P702983
Pureza: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Relb; V-Rel Reticuloendotheliosis Viral Oncogene Homolog B, Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3; Relb Proto-Oncogene, NF-KB Subunit; I-REL; Transcription Factor Relb; IMD53; REL-B; I-Rel; V-Rel Avian Reticuloendotheliosis
Species:
Human
Source:
Sf9 insect cells
Referencia número: HY-117222
No. CAS: 1202764-61-1
Target:
Áreas de investigación:
AM-0216 is a selective NIK inhibitor (Ki 2.0 nM) that acts on the non-canonical NF‑κB signaling pathway. AM‑0216 selectively inhibits NIK-dependent NF‑κB activation, reduces RelB:p52 activity, and inhibits BAFF receptor-induced NF‑κB activity. AM‑0216 induces apoptosis and NIK-dependent cytotoxicity in myeloma cells, inhibits cell clonogenic formation, and suppresses tumor growth in B-cell malignancies with constitutive NIK activation. AM-0216 can be used for research on mantle cell lymphoma, multiple myeloma, and B-cell malignancies .
Referencia número: HY-L014
1,857 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.
MCE owns a unique collection of 1,857 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
