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Roridin A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Endogenous Metabolite (2) Fungal (2) Insecticide (1) Parasite (1) Phosphatase (1)
By Research Areas:	Cancer (1) Infection (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9599

Roridin A	Fungal Endogenous Metabolite Parasite Insecticide	Infection
Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita) .

HY-125539

Roridin E	Antibiotic Phosphatase Fungal	Infection
Roridin E is a glucose-6-phosphatase (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies .

HY-N8400

Roridin L2	Endogenous Metabolite	Others
Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .

HY-N14586

Roridin J	Others	Cancer
Roridin J is a macrocyclic trichothecene and has anti-leukemia effect in mice .

HY-N12908

Roridin H Verrucarin H	Antibiotic	Infection
Roridin H (Verrucarin H) is an antibiotic and can be isolated from Myrothecium verrucaria .

HY-N14593

Roridin D	Others	Infection
Roridin D is a natural compound foun in Myrothecium roridum S-1135 (NRRL 3005) .

Roridin A	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Fungal Endogenous Metabolite Parasite Insecticide
Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita) .

Roridin E	Structural Classification Natural Products Microorganisms Source Classification	Antibiotic Phosphatase Fungal
Roridin E is a glucose-6-phosphatase (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies .

Roridin L2	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .

Roridin J	Natural Products Microorganisms Source Classification	Others
Roridin J is a macrocyclic trichothecene and has anti-leukemia effect in mice .

Roridin H Verrucarin H	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Antibiotic
Roridin H (Verrucarin H) is an antibiotic and can be isolated from Myrothecium verrucaria .

Roridin D	Natural Products Microorganisms Source Classification	Others
Roridin D is a natural compound foun in Myrothecium roridum S-1135 (NRRL 3005) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Roridin A

Inhibitors & Agonists

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Natural
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