S1PR3

Isoforms Recommended:	S1PR3

By Targets:	Akt (3) Apolipoprotein (1) Aryl Hydrocarbon Receptor (3) Environmental Pollutants (1) GSK-3 (2) JAK (2) LPL Receptor (10) Mitochondrial Metabolism (1) NO Synthase (1) p38 MAPK (1) PI3K (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Small Interfering RNA (siRNA) (3) STAT (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011338

Benzyl butyl phthalate 1 Publications Verification	Environmental Pollutants Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-NP203

High density lipoprotein (human) HDL (human)	Apolipoprotein NO Synthase LPL Receptor Akt PI3K p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .

HY-13660

Mocravimod hydrochloride 2 Publications Verification KRP-203	LPL Receptor Reactive Oxygen Species (ROS) Akt GSK-3 JAK STAT	Metabolic Disease Inflammation/Immunology Cancer
Mocravimod (hydrochloride) is an orally active sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod (hydrochloride) preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod (hydrochloride) significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3. Mocravimod (hydrochloride) retains T cell effector function. Mocravimod (hydrochloride) can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) .

HY-109038

Mocravimod 2 Publications Verification KRP-203 free base	LPL Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Akt GSK-3 JAK STAT	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Mocravimod (KRP-203 free base) is a sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3. Mocravimod retains T cell effector function. Mocravimod can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) .

HY-W011338S

Benzyl butyl phthalate-d4	Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate . Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-RS12399

S1pr3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
S1pr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr3 Rat Pre-designed siRNA Set A S1pr3 Rat Pre-designed siRNA Set A

HY-RS12398

S1pr3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LPL Receptor	Others
S1pr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr3 Mouse Pre-designed siRNA Set A S1pr3 Mouse Pre-designed siRNA Set A

HY-RS12397

S1PR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LPL Receptor	Others
S1PR3 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1PR3 Human Pre-designed siRNA Set A S1PR3 Human Pre-designed siRNA Set A

HY-100953

CYM-5520 1 Publications Verification	LPL Receptor	Metabolic Disease
CYM-5520 is a selective and allosteric sphingosine 1-phosphate receptor 2 (S1PR2) agonist with an EC₅₀ of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research .

HY-W011338R

Benzyl butyl phthalate (Standard)	Reference Standards Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate (Standard) is the analytical standard of Benzyl butyl phthalate. This product is intended for research and analytical applications. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-N16096

VPC 01091	LPL Receptor	Metabolic Disease
VPC 01091 is a S1PR3 antagonist.

HY-182618

XAX-162	LPL Receptor	Others
XAX-162 is a highly selective sphingosine 1-phosphate receptor 2 (S1PR2) agonist with a human EC₅₀ of 0.55 μM. XAX-162 does not activate other S1P receptors. XAX-162 exhibits noncompetitive inhibition of activity by S1PR2 antagonist JTE-013 (HY-100675) .

HY-183578

TYY-31	LPL Receptor	Inflammation/Immunology
TYY-31 is an orally active, selective S1PR1 agonist with an EC₅₀ of 1.13 pM. TYY-31 promotes the phosphorylation of ERK1/2. TYY-31 exerts anti-inflammatory and immunosuppressive effects, ameliorates DSS-induced colitis in mice, and reduces peripheral blood lymphocyte counts in mice in a dose-dependent manner. TYY-31 can be used for the research of ulcerative colitis .

HY-181875

S1PR1/S1PR5 agonist-1	LPL Receptor	Inflammation/Immunology
S1PR1/S1PR5 agonist-1 (Compound 19) is an orally active S1PR1 and S1PR5 agonist with EC₅₀ values of 40.0 and 22.9 nM, respectively. S1PR1/S1PR5 agonist-1 binds to key residues of S1PR1 to mediate agonistic activity. S1PR1/S1PR5 agonist-1 alleviates colitis pathological changes in DSS-induced mouse models and exerts minimal effects on mouse heart rate. S1PR1/S1PR5 agonist-1 can be used for the research of inflammatory bowel disease .

Cat. No.	Product Name	Type

HY-NP203

High density lipoprotein (human) HDL (human)	Biochemical Assay Reagents
High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .

High density lipoprotein (human)

HDL (human)

Biochemical Assay Reagents

High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .

Cat. No.	Product Name	Chemical Structure

HY-W011338S

Benzyl butyl phthalate-d4
Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate . Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate . Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82614

	EDG3 Antibody (YA2359) S1PR3; EDG3; Sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3	WB	Human, Mouse, Rat
	EDG3 Antibody (YA2359) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EDG3.

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Cat. No.	Product Name		Classification

HY-RS12399

S1pr3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
S1pr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12398

S1pr3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
S1pr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12397

S1PR3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
S1PR3 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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