Search Result

Results for "

S228P

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Apelin Receptor (APJ) (1) Apolipoprotein (1) c-Met/HGFR (1) CCR (2) CD28 (5) CD3 (3) CD38 (1) CD47 (4) CD73 (1) Claudin (1) Complement System (2) CXCR (1) EGFR (1) ERK (1) GCGR (1) GDNF Receptor (2) Human leukocyte immunoglobulin (Ig)-like receptors (LILR) (1) Integrin (3) Interleukin Related (10) LAG-3 (4) LILRB (1) MHC (1) NAMPT (1) Natriuretic Peptide Receptor (NPR) (1) PD-1/PD-L1 (3) Small Interfering RNA (siRNA) (1) TAM Receptor (1) TGF-beta/Smad (2) Thrombin (1) Tim3 (1) TNF Receptor (4) Transmembrane Glycoprotein (8) Wnt (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Inflammation/Immunology (55) Neurological Disease (1)

By Targets:

ADC Antibody (1)

Apelin Receptor (APJ) (1)

Apolipoprotein (1)

c-Met/HGFR (1)

CCR (2)

CD28 (5)

CD3 (3)

CD38 (1)

CD47 (4)

CD73 (1)

Claudin (1)

Complement System (2)

CXCR (1)

EGFR (1)

ERK (1)

GCGR (1)

GDNF Receptor (2)

Human leukocyte immunoglobulin (Ig)-like receptors (LILR) (1)

Integrin (3)

Interleukin Related (10)

LAG-3 (4)

LILRB (1)

MHC (1)

NAMPT (1)

Natriuretic Peptide Receptor (NPR) (1)

PD-1/PD-L1 (3)

Small Interfering RNA (siRNA) (1)

TAM Receptor (1)

TGF-beta/Smad (2)

Thrombin (1)

Tim3 (1)

TNF Receptor (4)

Transmembrane Glycoprotein (8)

Wnt (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (3)

Inflammation/Immunology (55)

Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Visugromab 2 Publications Verification CTL-002	TGF-beta/Smad PD-1/PD-L1	Cancer
Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Gemtuzumab	ADC Antibody Transmembrane Glycoprotein	Cancer
Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Sabatolimab 1 Publications Verification MBG453	Tim3	Inflammation/Immunology
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells .

Favezelimab MK-4280; Mavezelimab	LAG-3	Cancer
Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand, MHC class II molecules. Favezelimab is applicable to research on relapsed/refractory classical Hodgkin lymphoma, relapsed/refractory diffuse large B-cell lymphoma, and relapsed/refractory indolent B-cell lymphoma . For the isotype control of Favezelimab, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Riliprubart SAR 445088	Complement System	Inflammation/Immunology
Riliprubart (SAR 445088) is an anti-C1s humanized IgG4 monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. Riliprubart can be used to study complement-mediated diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

ALT-100 (Human IgG4)	NAMPT	Inflammation/Immunology
ALT-100 (Human IgG4) is a humanized antibody expressed in CHO, targeting NAMPT. ALT-100 (Human IgG4) consists of a huIgG1/huIgG4 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For inflammatory or fibrotic diseases, the isotype control for ALT-100 (Human IgG4) can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

SAR-442257	CD28 CD38 CD3	Cancer
SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting CD38 and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .

Eltrekibart LY-3041658	CXCR	Inflammation/Immunology
Eltrekibart is an anti-CXCL human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Venanprubart LY-3361237	CD28	Inflammation/Immunology
Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Abiprubart KPL-404	TNF Receptor	Inflammation/Immunology
Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Zadoprubart	CD28	Inflammation/Immunology
HY-P991038 is an BTLA-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Nelmastobart HSTC-810	Transmembrane Glycoprotein	Inflammation/Immunology
Nelmastobart is an anti-BTN1A1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Dalmitamig bsAb7075; REGN-7075; Marlotamig	EGFR	Inflammation/Immunology
HY-P990913 is an EGFR/CD28-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Vensobafusp alfa KP-104	Complement System	Inflammation/Immunology
Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .

STI-6643	CD47	Cancer
STI-6643 is a fully human IgG4 antibody that targets CD47. STI-6643 blocks CD47-SIRPα interaction, and enables macrophage-mediated phagocytosis of tumor cells. STI-6643 shows anti-tumor activity in mouse lymphoma xenograft models. STI-6643 can be used for the research of Burkitt's lymphoma, solid tumors, relapsed or refractory tumors, and lymphoma. The isotype control for STI-6643 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Negalstobart IBI-110	LAG-3	Inflammation/Immunology
Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Vilamakitug XB-2001	Interleukin Related	Inflammation/Immunology
Vilamakitug (XB-2001) is an anti-IL-1α human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

ADG-106	TNF Receptor	Cancer
ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Camtarkibart	Interleukin Related	Inflammation/Immunology
Camtarkibart is an anti-IL4R IgG4κ type humanized antibody with immunomodulator activity. The recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Nezastomig REGN-5678	CD28	Inflammation/Immunology
Nezastomig is an anti-FOLH1/CD28 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Birinkibart	Transmembrane Glycoprotein	Inflammation/Immunology
HY-P990975 is an CSF2RB-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Gentulizumab Gensci-059	CD47	Cancer
Gentulizumab (Gensci-059) is a humanized IgG4 antibody that targets CD47. Gentulizumab displays strong binding to CD47 in both human and monkey, and effectively inhibits the CD47-SIRPα interaction. Gentulizumab exhibits a potent antitumor activity. The isotype control for Gentulizumab can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Visugromab (Powder) CLT-002 (Powder)	TGF-beta/Smad PD-1/PD-L1	Cancer
Visugromab (CTL-002) (Powder) is a GDF-15 neutralizing IgG4 mAb. Visugromab (Powder) has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Baloncibart	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology
Baloncibart is a human IgG4K antibody targeting NPR1. The corresponding isotype control is: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Pradusinstobart LVGN-3616	PD-1/PD-L1	Inflammation/Immunology
Pradusinstobart is an anti-PDCD1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Roconkibart JS-005	Interleukin Related	Inflammation/Immunology
Roconkibart is an anti-IL17A human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Umikibart YYB-101; ABX101	c-Met/HGFR	Inflammation/Immunology
HY-P990949 is an HGF-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Lucorafusp alfa AK-130	Transmembrane Glycoprotein	Inflammation/Immunology
HY-P990960 is an TIGIT-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Alcestobart LBL-007	LAG-3	Inflammation/Immunology
HY-P990968 is an LAG3-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Brivestobart GLS-012	LAG-3	Inflammation/Immunology
HY-P990976 is an LAG3-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Ciduvectamig JNJ-70218902; JNJ-902	CD3	Inflammation/Immunology
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Comekibart MG-K10	Interleukin Related	Inflammation/Immunology
HY-P990910 is an IL4R-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Drotokibart SHR-1819	Interleukin Related	Inflammation/Immunology
HY-P990983 is an IL4RA-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Mavrostobart	CD73	Inflammation/Immunology
HY-P991009 is an NT5E-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Ebribafusp alfa ADX-097	CD3	Inflammation/Immunology
HY-P990955 is an CD3E-targeting IgG4κ type chimeric antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Zamristobart SAR-444881	Human leukocyte immunoglobulin (Ig)-like receptors (LILR) LILRB	Inflammation/Immunology Cancer
Zamristobart is an anti-LILRB1 (leukocyte immunoglobulin-like receptor B1) IgG4κ type humanized antibody with immunostimulant and antineoplastic activities. The recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

Anti-Thrombin Antibody	Thrombin	Cardiovascular Disease
Anti-Thrombin Antibody is an anti-Thrombin antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-ITGAD Antibody	Integrin	Inflammation/Immunology
Anti-ITGAD Antibody is an anti-ITGAD antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-Glucagon Antibody	GCGR	Inflammation/Immunology
Anti-Glucagon Antibody is an anti-Glucagon antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-ApoCIII Antibody	Apolipoprotein	Cardiovascular Disease
Anti-ApoCIII Antibody is an antibody against human ApoCIII. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-APLNR Antibody	Apelin Receptor (APJ)	Cardiovascular Disease
Anti-APLNR Antibody is an antibody against human APLNR. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-CNTFR Antibody	GDNF Receptor	Neurological Disease
Anti-CNTFR Antibody is an antibody against human CNTFR. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-HLA-C Antibody	MHC	Inflammation/Immunology
Anti-HLA-C Antibody is an anti-HLA-C antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-CD81 Antibody	Transmembrane Glycoprotein	Cancer
Anti-CD81 Antibody is an antibody against human CD81. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-CD47 Antibody (1F80)	CD47	Cancer
Anti-CD47 Antibody (1F80) is an antibody against human CD47. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Anti-Big-ET-1 Antibody	ERK	Others
Anti-Big-ET-1 Antibody is a humanized monoclonal antibody targeting Big-ET-1. Recommended Isotype Control: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Cat. No.	Product Name	Target	Research Area	Image

HY-P99003

*Human IgG4 (S228P) kappa, Isotype Control* Maximum Cited Publications 9 Publications Verification	Inhibitory Antibodies	Inflammation/Immunology
Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.

HY-P99100

Visugromab 2 Publications Verification CTL-002	TGF-beta/Smad PD-1/PD-L1	Cancer
Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P99971

Gemtuzumab	ADC Antibody Transmembrane Glycoprotein	Cancer
Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P99987

*Human IgG4 (S228P) lambda1, Isotype Control*	Inhibitory Antibodies	Inflammation/Immunology
Human IgG4 (S228P) lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG4 (S228P) λ1 antibody.

HY-P99044

Sabatolimab 1 Publications Verification MBG453	Tim3	Inflammation/Immunology
Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells .

HY-P99176

ATG-031 4 Publications Verification	Inhibitory Antibodies	Cancer
ATG-031 is a humanized anti-CD24 monoclonal antibody with high affinity and specificity. ATG-031 interacts with Siglec-10 expressed by tumor-associated macrophages. ATG-031 effectively stimulates macrophage-mediated phagocytosis and induces cancer cell destruction by blocking the anti-phagocytic surface proteins. ATG-031 can be used in the study of haematological malignancies as well as solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P99613

Favezelimab MK-4280; Mavezelimab	LAG-3	Cancer
Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand, MHC class II molecules. Favezelimab is applicable to research on relapsed/refractory classical Hodgkin lymphoma, relapsed/refractory diffuse large B-cell lymphoma, and relapsed/refractory indolent B-cell lymphoma . For the isotype control of Favezelimab, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990091

Riliprubart SAR 445088	Complement System	Inflammation/Immunology
Riliprubart (SAR 445088) is an anti-C1s humanized IgG4 monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. Riliprubart can be used to study complement-mediated diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990319

ALT-100 (Human IgG4)	NAMPT	Inflammation/Immunology
ALT-100 (Human IgG4) is a humanized antibody expressed in CHO, targeting NAMPT. ALT-100 (Human IgG4) consists of a huIgG1/huIgG4 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For inflammatory or fibrotic diseases, the isotype control for ALT-100 (Human IgG4) can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991183

SAR-442257	CD28 CD38 CD3	Cancer
SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting CD38 and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .

HY-P990737

Eltrekibart LY-3041658	CXCR	Inflammation/Immunology
Eltrekibart is an anti-CXCL human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990773

Venanprubart LY-3361237	CD28	Inflammation/Immunology
Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990743

Gruticibart AB023; Xisomab 3G3; MAB 14E11	Inhibitory Antibodies	Inflammation/Immunology
Gruticibart is an anti-F11 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990726

Abiprubart KPL-404	TNF Receptor	Inflammation/Immunology
Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991038

Zadoprubart	CD28	Inflammation/Immunology
HY-P991038 is an BTLA-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990751

Nelmastobart HSTC-810	Transmembrane Glycoprotein	Inflammation/Immunology
Nelmastobart is an anti-BTN1A1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990913

Dalmitamig bsAb7075; REGN-7075; Marlotamig	EGFR	Inflammation/Immunology
HY-P990913 is an EGFR/CD28-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990917

Ebrasodebart	Inhibitory Antibodies	Inflammation/Immunology
HY-P990917 is an TMEM219-targeting IgG4λ type human antibody, the recommed isotype control is Human IgG4 (S228P) lambda1, Isotype Control (HY-P99987) .

HY-P991067

Vensobafusp alfa KP-104	Complement System	Inflammation/Immunology
Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .

HY-P991057

STI-6643	CD47	Cancer
STI-6643 is a fully human IgG4 antibody that targets CD47. STI-6643 blocks CD47-SIRPα interaction, and enables macrophage-mediated phagocytosis of tumor cells. STI-6643 shows anti-tumor activity in mouse lymphoma xenograft models. STI-6643 can be used for the research of Burkitt's lymphoma, solid tumors, relapsed or refractory tumors, and lymphoma. The isotype control for STI-6643 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990750

Negalstobart IBI-110	LAG-3	Inflammation/Immunology
Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990691

Vilamakitug XB-2001	Interleukin Related	Inflammation/Immunology
Vilamakitug (XB-2001) is an anti-IL-1α human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991070

ADG-106	TNF Receptor	Cancer
ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P991675

Camtarkibart	Interleukin Related	Inflammation/Immunology
Camtarkibart is an anti-IL4R IgG4κ type humanized antibody with immunomodulator activity. The recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990752

Nezastomig REGN-5678	CD28	Inflammation/Immunology
Nezastomig is an anti-FOLH1/CD28 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990975

Birinkibart	Transmembrane Glycoprotein	Inflammation/Immunology
HY-P990975 is an CSF2RB-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P991062

Gentulizumab Gensci-059	CD47	Cancer
Gentulizumab (Gensci-059) is a humanized IgG4 antibody that targets CD47. Gentulizumab displays strong binding to CD47 in both human and monkey, and effectively inhibits the CD47-SIRPα interaction. Gentulizumab exhibits a potent antitumor activity. The isotype control for Gentulizumab can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P99100A

Visugromab (Powder) CLT-002 (Powder)	TGF-beta/Smad PD-1/PD-L1	Cancer
Visugromab (CTL-002) (Powder) is a GDF-15 neutralizing IgG4 mAb. Visugromab (Powder) has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990696

Resugosbart SHR-1222	Inhibitory Antibodies	Inflammation/Immunology
Resugosbart is an anti-SOST human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991121

Baloncibart	Natriuretic Peptide Receptor (NPR)	Inflammation/Immunology
Baloncibart is a human IgG4K antibody targeting NPR1. The corresponding isotype control is: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990702

Pradusinstobart LVGN-3616	PD-1/PD-L1	Inflammation/Immunology
Pradusinstobart is an anti-PDCD1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990761

Roconkibart JS-005	Interleukin Related	Inflammation/Immunology
Roconkibart is an anti-IL17A human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990949

Umikibart YYB-101; ABX101	c-Met/HGFR	Inflammation/Immunology
HY-P990949 is an HGF-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990960

Lucorafusp alfa AK-130	Transmembrane Glycoprotein	Inflammation/Immunology
HY-P990960 is an TIGIT-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990968

Alcestobart LBL-007	LAG-3	Inflammation/Immunology
HY-P990968 is an LAG3-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990976

Brivestobart GLS-012	LAG-3	Inflammation/Immunology
HY-P990976 is an LAG3-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990692

Ciduvectamig JNJ-70218902; JNJ-902	CD3	Inflammation/Immunology
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990910

Comekibart MG-K10	Interleukin Related	Inflammation/Immunology
HY-P990910 is an IL4R-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990983

Drotokibart SHR-1819	Interleukin Related	Inflammation/Immunology
HY-P990983 is an IL4RA-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P991009

Mavrostobart	CD73	Inflammation/Immunology
HY-P991009 is an NT5E-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990955

Ebribafusp alfa ADX-097	CD3	Inflammation/Immunology
HY-P990955 is an CD3E-targeting IgG4κ type chimeric antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P991727

Zamristobart SAR-444881	Human leukocyte immunoglobulin (Ig)-like receptors (LILR) LILRB	Inflammation/Immunology Cancer
Zamristobart is an anti-LILRB1 (leukocyte immunoglobulin-like receptor B1) IgG4κ type humanized antibody with immunostimulant and antineoplastic activities. The recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P991987

Anti-Thrombin Antibody	Thrombin	Cardiovascular Disease
Anti-Thrombin Antibody is an anti-Thrombin antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P992050

Anti-ITGAD Antibody	Integrin	Inflammation/Immunology
Anti-ITGAD Antibody is an anti-ITGAD antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P992006

Anti-Glucagon Antibody	GCGR	Inflammation/Immunology
Anti-Glucagon Antibody is an anti-Glucagon antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991865

Anti-ApoCIII Antibody	Apolipoprotein	Cardiovascular Disease
Anti-ApoCIII Antibody is an antibody against human ApoCIII. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991861

Anti-APLNR Antibody	Apelin Receptor (APJ)	Cardiovascular Disease
Anti-APLNR Antibody is an antibody against human APLNR. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991945

Anti-CNTFR Antibody	GDNF Receptor	Neurological Disease
Anti-CNTFR Antibody is an antibody against human CNTFR. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P992017

Anti-HLA-C Antibody	MHC	Inflammation/Immunology
Anti-HLA-C Antibody is an anti-HLA-C antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P991933

Anti-CD81 Antibody	Transmembrane Glycoprotein	Cancer
Anti-CD81 Antibody is an antibody against human CD81. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

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