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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

SARS-CoV-2 3C-like protease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (12) Virus Protease (3) HCV (1) HIV (1) Isotope-Labeled Compounds (1) Reference Standards (1)
By Research Areas:	Infection (12) Inflammation/Immunology (4)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: SARS-CoV Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) ClpP TMPRSS6 Calpain Serpin Enteropeptidase Ser/Thr Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138687

Nirmatrelvir 100+ Cited Publications PF-07321332	SARS-CoV	Infection Inflammation/Immunology
Nirmatrelvir (PF-07321332) is a potent and orally active *SARS-CoV 3C-like* protease (3CL ^PRO)** inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

HY-172437

Secutrelvir S-892216	Virus Protease SARS-CoV	Infection
Secutrelvir is an oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor and antiviral agent, with IC₅₀ values of 0.655 nM and 0.697 nM against SARS-CoV-2 3CLpro, respectively. Secutrelvir forms a reversible covalent bond with the catalytic cysteine C145 of SARS-CoV-2 3CLpro, thereby inhibiting viral replication. Secutrelvir exhibits activity against multiple SARS-CoV-2 variants and can be used in research related to coronavirus disease 2019 (COVID-19) .

HY-137048

PF-00835231 4 Publications Verification	SARS-CoV HIV HCV	Infection
PF-00835231 is a CoV-2 *cysteine 3C-like* protease (3CL ^pro) inhibitor, with IC₅₀*s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CL ^pro, respectively. PF-00835231 is developed for the research of anti-SARS-CoV-2*/COVID-19. PF-00835231 can inhibit cell infections and also suppress infections in animal models .

HY-156651

Zevotrelvir EDP-235	SARS-CoV Virus Protease	Infection
Zevotrelvir (EDP-235) is a coronavirus inhibitor that can inhibit 229E hCoV and the SARS-CoV-2 3C-like (3CL) protease (IC₅₀ <0.1 mM). Zevotrelvir can be used in research on coronavirus infections .

HY-145435

SARS-CoV-2-IN-12	SARS-CoV	Infection
SARS-CoV-2-IN-12 (Compound 27) is a potent *SARS-CoV-2*-related 3C-like protease inhibitor (K_i=32.1 pM) for preventing SARS-CoV-2 viral replication and that could be useful in the research of COVID-19 .

HY-138687R

Nirmatrelvir (Standard) PF-07321332 (Standard)	Reference Standards SARS-CoV	Infection Inflammation/Immunology
Nirmatrelvir (Standard) is the analytical standard of Nirmatrelvir. This product is intended for research and analytical applications. Nirmatrelvir (PF-07321332) is a potent and orally active *SARS-CoV 3C-like* protease (3CL ^PRO)** inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

HY-143470

SARS-CoV-2-IN-18	SARS-CoV	Infection
SARS-CoV-2-IN-18 (Compound 26) is a potent **SARS-CoV-2 3C-like protease inhibitor with an IC₅₀** of 45 nM .

HY-145277

SARS-CoV-2-IN-11	SARS-CoV	Infection
SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of **SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀** of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-145276

SARS-CoV-2-IN-10	SARS-CoV	Infection
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of **SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀** of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-151535

SARS-CoV-2 3CLpro-IN-5	SARS-CoV	Infection Inflammation/Immunology
SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor of 3C-like protease (3CL ^pro). SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CL ^pro with an IC₅₀ value of 3.8 nM. SARS-CoV-2 3CLpro-IN-5 has 9.0% oral bioavailability (BA). SARS-CoV-2 3CLpro-IN-5 can be used for the research of coronavirus disease 2019 (COVID-19) .

HY-138687S1

Nirmatrelvir-d6 PF-07321332-d₆	Isotope-Labeled Compounds SARS-CoV	Infection Inflammation/Immunology
Nirmatrelvir-d₆ (PF-07321332-d₆) is deuterium labeled Nirmatrelvir. Nirmatrelvir (PF-07321332) is a potent and orally active *SARS-CoV 3C-like* protease (3CL ^PRO)** inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

HY-183752

CG-0988	SARS-CoV Virus Protease	Infection
CG-0988 is a selective *SARS-CoV-2* 3C-like protease (3CL ^pro) inhibitor with an IC₅₀ of 8.5 nM. CG-0988 functionally inhibits SARS-CoV-2 3CL ^pro, blocks SARS-CoV-2 replication, and exerts antiviral activity against SARS-CoV-2 variants. CG-0988 can be used in research related to coronavirus disease 2019 (COVID-19) .

Recombinant Proteins Recommended:

SARS-CoV-2 3C-like Protease

Species:	Virus (5)
Tag:	His (3) Tag Free (2) Avi (2)
Source:	Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78275

	SARS-CoV-2 3CLpro/3C-like protease Protein 3C-like protease; 3CL protease; 3CL-Mpro; 3CL Pro; CoVID-19; M Proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease is a viral cysteine protease that plays a crucial role in the co-translational proteolytic processing of coronavirus polyproteins. Since no homologous proteins with similar cleavage sites exist in the human body, SARS-CoV-2 3CLpro/3C-like protease is a high-quality target for the development of drugs related to COVID-19. SARS-CoV-2 3CLpro/3C-like protease protein is a recombinant, untagged SARS-CoV-2 3CLpro/3C-like protease protein expressed by E.coli.

HY-P78275A

	SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) 3C-like protease; 3CL protease; 3CL-Mpro; 3CL Pro; CoVID-19; M Proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a viral cysteine protease that plays a crucial role in the co-translational proteolytic processing of coronavirus polyproteins. Since no homologous proteins with similar cleavage sites exist in the human body, SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a high-quality target for the development of drugs related to COVID-19. SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a recombinant, SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) expressed by E.coli.

HY-P76590

	SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) 3CL protease; 3CL Proteinase; 3C-like main protease; 3CL-Mpro; CoVID-19; M Proteinase; Main protease; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by E. coli, with N-His, N-Avi labeled tag.

HY-P76589

	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) 3CL protease; 3CL Proteinase; 3C-like main protease; 3CL-Mpro; CoVID-19; M Proteinase; Main protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells, with N-His labeled tag.

HY-P76591

	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) 3CL protease; 3CL Proteinase; 3C-like main protease; 3CL-Mpro; CoVID-19; M Proteinase; Main protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells, with N-His, N-Avi labeled tag.

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HY-138687S1

Nirmatrelvir-d6
Nirmatrelvir-d₆ (PF-07321332-d₆) is deuterium labeled Nirmatrelvir. Nirmatrelvir (PF-07321332) is a potent and orally active *SARS-CoV 3C-like* protease (3CL ^PRO)** inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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