9 Results for "

SARS-CoV-2 membrane protein

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "SARS-CoV-2 membrane protein" in MCE Product Catalog:

2
Cephaeline
Cephaeline
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2 Cited Publications
Cat. No.: HY-N4118
CAS No.: 483-17-0
Synonyms: (-)-Cephaeline; NSC 32944 free base
Category:  

Infection Alkaloids Monophenols Phenols Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline ((-)-Cephaeline; NSC 32944) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline inhibits cancer cell proliferation, migration and tumor growth. Cephaeline inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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CIM-834
CIM-834
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Cat. No.: HY-172760
CAS No.: 3104363-32-5
Target:  

SARS-CoV

Research Areas:  

Infection

CIM-834 is an orally effective inhibitor of SARS-CoV-2 membrane protein. CIM-834 can prevent the assembly of infectious virus particles without inhibiting the synthesis of viral RNA. CIM-834 can reduce the viral titer in the lungs of SCID mice infected nasally with SARS-CoV-2, block the spread of SARS-CoV-2 among Syrian hamsters, and inhibit the replication of SARS-CoV-2 (including variants) and SARS-CoV. CIM-834 can be used in related research on COVID-19 .
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Cephaeline hydrochloride
Cephaeline hydrochloride
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Cat. No.: HY-N2076
CAS No.: 3738-70-3
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Category:  

Infection Alkaloids Monophenols Phenols Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline hydrochloride ((-)-Cephaeline (hydrochloride); NSC 32944 (monohydrochloride)) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline hydrochloride induces Ferroptosis by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline hydrochloride inhibits cancer cell proliferation, migration and tumor growth. Cephaeline hydrochloride inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline hydrochloride can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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Spike Glycoprotein (1147-1162)
Spike Glycoprotein (1147-1162)
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Cat. No.: HY-P10976
Target:  

SARS-CoV

Research Areas:  

Infection

Spike Glycoprotein (1147-1162) is a linear and broadly neutralizing peptide in the S2 protein of SARS-CoV-2. Spike Glycoprotein (1147-1162) is conserved across SARS-CoV, BatCoV RaTG13, SARS-CoV-2, and SARS-CoV-2 variants. Spike Glycoprotein (1147-1162)-targeting mAbs can neutralize both SARS-CoV-2 and SARS-CoV by preventing fusion between the virus and cell membrane. Spike Glycoprotein (1147-1162) can be used for universal vaccines against SARS-CoV-2 mutants research .
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SARS-CoV-2-IN-122
SARS-CoV-2-IN-122
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Cat. No.: HY-182913
Target:  

SARS-CoV

Research Areas:  

Infection

SARS-CoV-2-IN-122 is a SARS-CoV-2 inhibitor by targeting the S2 subunit of the spike protein. SARS-CoV-2-IN-122 interacts with residues linked to membrane fusion-associated conformational rearrangements, interfering with viral entry events. SARS-CoV-2-IN-122 inhibits SARS-CoV-2 replication, lacks direct virucidal activity, and does not impair viral-host cell attachment. SARS-CoV-2-IN-122 exhibits activity against SARS-CoV-2 variants including B.1 and Omicron (BA.2.86.1). SARS-CoV-2-IN-122 can be used for the research of coronavirus disease 2019 (COVID-19) .
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KZR-8445
KZR-8445
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Cat. No.: HY-P10466
CAS No.: 2377734-91-1
Target:  

Sec61 SARS-CoV Interleukin Related TNF Receptor IFNAR

Research Areas:  

Infection Inflammation/Immunology

KZR-8445, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection .
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KZR-8445 TFA
KZR-8445 TFA
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Cat. No.: HY-P10466A
Target:  

Sec61 SARS-CoV Interleukin Related TNF Receptor IFNAR

Research Areas:  

Infection Inflammation/Immunology

KZR-8445 TFA, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 TFA binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 TFA inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 TFA inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 TFA blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 TFA can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection .
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SARS-M Antibody (YA5057)
SARS-M Antibody (YA5057)
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Cat. No.: HY-P85365
Synonyms: membrane glycoprotein, 2019-nCoV membrane glycoprotein, M protein, SARS CoV 2

Host:  

Mouse

Application:  

WB, ELISA

Reactivity:  

Virus

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Cephaeline dihydrobromide
Cephaeline dihydrobromide
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Cat. No.: HY-N4118A
CAS No.: 6014-81-9
Synonyms: (-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide
Category:  

Alkaloids Monophenols Phenols Plants Other Families Extract Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline dihydrobromide ((-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline dihydrobromide induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline dihydrobromide inhibits cancer cell proliferation, migration and tumor growth. Cephaeline dihydrobromide inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline dihydrobromide can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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