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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
SGI 1776
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "SGI 1776" in MCE Product Catalog:
11
Cat. No.: HY-13287A
CAS No.: 1173928-26-1
Research Areas:
SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively .
Cat. No.: HY-186146A
CAS No.: 3013618-85-1
Synonyms: SGI-1776-cis-VHL-02
SGI-1776-VHL-02-epimer (SGI-1776-cis-VHL-02) is an epimer control compound of with SGI-1776-VHL-02 (HY-186146). SGI-1776-VHL-02-epimer has an inverted stereocenter in the critical hydroxyl-proline group in the VHL ligand. SGI-1776-VHL-02-epimer cannot trigger the VHL E3 ligase complex and does not degrade PIM1 .
Cat. No.: HY-186146
CAS No.: 3013618-84-0
SGI-1776-VHL-02 is a stereoselective PIM PROTAC degrader. SGI-1776-VHL-02 promotes the ubiquitination and degradation of PIM1, PIM2 and PIM3. SGI-1776-VHL-02 downregulates c-myc protein levels, induces Apoptosis. SGI-1776-VHL-02 has anti-cancer activity against prostate cancer. SGI-1776-VHL-02 can be used in studies related to prostate cancer .
Cat. No.: HY-186147
CAS No.: 3013618-83-9
Research Areas:
SGI-1776-amide-C6-acid (Compound S4) is a Target Protein Ligand-Linker Conjugate that contains a Pim inhibitor (HY-13287) and a PROTAC linker, and can recruit E3 ligase. SMARCA2 Ligand-Linker Conjugate-4 is applicable for the synthesis of PROTAC SGI-1776-VHL-02 (HY-186146) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
