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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
SIM-1
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "SIM-1" in MCE Product Catalog:
1
1 Cited Publications
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SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC50=1.1 nM; Kd=186 nM). SIM1 shows sustained anti-cancer activity [1].
Cat. No.: HY-W088065
CAS No.: 141-53-7
Cat. No.: HY-RS12922
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SIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-141438A
CAS No.: 2719051-98-4
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cis-SIM1 is a negative control of SIM1 [1].
Cat. No.: HY-RS18152
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Sim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184990
CAS No.: 2719051-81-5
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E3 Ligase Ligand-linker Conjugate 239 (Compound 20) is a VHL ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 239 is used for the synthesis of BRD2 PROTAC degrader SIM1 (HY-141438) [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
