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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
SM1
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "SM1" in MCE Product Catalog:
16
Target:
Research Areas:
Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model [1] .
16
16 Publications Verification
Cat. No.: HY-19620A
CAS No.: 1562338-39-9
Synonyms: LMI070 hydrochloride; NVS-SM1 hydrochloride
Target:
Research Areas:
Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model [1] .
2
2 Cited Publications
Cat. No.: HY-P990131
Target:
Research Areas:
Research Areas:
SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines [1] .
Cat. No.: HY-136849
Purity: 98.88%
Research Areas:
TL13-68 is a biotin-tagged version of SM1-71, and it can be used to research the mechanism of SM1-71 [1].
Cat. No.: HY-RS16453
Target:
Research Areas:
SM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-138966
CAS No.: 2088180-03-2
SM1-71-R is a reversible analog o SM1-71 (HY-136848). SM1-71-R lacks the acrylamide warhead and therefore cannot form a covalent bond with the kinase. SM1-71-R can be used as a control compound for SM1-71 [1].
Cat. No.: HY-N10805
CAS No.: 144606-83-7
Target:
Cat. No.: HY-155176
CAS No.: 2364448-93-9
SP-2-225 is a selective HDAC6 inhibitor. SP-2-225 enhance the production of cancer-associated antigens and macrophage antigen cross-presentation to T cells. SP-2-225 reduces the tumor volume in a syngeneic SM1 melanoma model [1].
Cat. No.: HY-178110
CAS No.: 3028442-70-5
Research Areas:
HDAC6-IN-65 is a selective HDAC6 inhibitor (IC50 = 0.9 nM) and also exhibits a certain suppressive effect on HDAC3 (IC50 = 39.4 nM). HDAC6-IN-65 can induce the accumulation of α-tubulin (ac-tubulin) and acetylated histone H3 (ac-histone H3, a class I HDAC inhibition marker) in Neuro-2a cells. HDAC6-IN-65 can be used for the study of melanoma [1].
Cat. No.: HY-N2836
CAS No.: 63399-38-2
Target:
Cat. No.: HY-N10806
CAS No.: 144606-84-8
Target:
Cat. No.: HY-N3833
CAS No.: 52611-75-3
Category:
Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Plants Cibotiaceae
Target:
Cat. No.: HY-N1573
CAS No.: 34169-69-2
Category:
Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Plants Cibotiaceae
Target:
Cat. No.: HY-N3834
CAS No.: 61117-89-3
Category:
Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Plants Cibotiaceae
Target:
Cat. No.: HY-N1572
CAS No.: 84299-80-9
Category:
Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Plants Cibotiaceae
Target:
Cat. No.: HY-N1808
CAS No.: 63399-37-1
Target:
Cat. No.: HY-N8881
CAS No.: 60263-06-1
Synonyms: Jacaranone ethyl ester
Target:
Cat. No.: HY-184203
SM-06-09 is a potent, highly selective, orally active tetrazolone-based HDAC6 inhibitor with an IC50 value of 0.49 nM. SM-06-09 promotes tumor-associated macrophage (TAM) polarization toward an antitumor M1-like phenotype and enhances macrophage phagocytosis, antigen presentation, and T-cell activation. SM-06-09 remodels the tumor immune microenvironment, exhibits antitumor activity in melanoma models, and enhances the efficacy of anti-PD-1 immune checkpoint blockade [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
