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SM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) CD47 (1) DNA/RNA Synthesis (2) FGFR (2) HDAC (2) Histone Methyltransferase (1) LIM Kinase (LIMK) (2) MAP3K (2) Microtubule/Tubulin (1) Potassium Channel (2) Ribosomal S6 Kinase (RSK) (2) Small Interfering RNA (siRNA) (1) Src (2)
By Research Areas:	Cancer (7) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Inhibitory Antibodies

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19620

Branaplam Maximum Cited Publications 15 Publications Verification LMI070; NVS-SM1	DNA/RNA Synthesis Potassium Channel	Cancer
Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model ^[1] .

HY-19620A

Branaplam hydrochloride Maximum Cited Publications 15 Publications Verification LMI070 hydrochloride; NVS-SM1 hydrochloride	DNA/RNA Synthesis Potassium Channel	Cancer
Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model ^[1] .

HY-136848

SM1-71	MAP3K Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK)	Cancer
SM1-71 (compound 5) is a potent *TAK1* inhibitor, with a K_i of 160 nM, it also can covalently inhibit MKNK2, *MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1* and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines ^[1] .

HY-P990131

Anti-Mouse CD47/IAP Antibody (MIAP301) 1 Publications Verification	CD47	Infection Inflammation/Immunology Cancer
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse CD47/IAP IgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis ^[1] .

HY-136849

TL13-68	Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK) MAP3K	Others
TL13-68 is a biotin-tagged version of SM1-71, and it can be used to research the mechanism of SM1-71 ^[1].

HY-RS16453

SM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SM1 Human Pre-designed siRNA Set A SM1 Human Pre-designed siRNA Set A

HY-138966

SM1-71-R	Akt	Cancer
SM1-71-R is a reversible analog o SM1-71 (HY-136848). SM1-71-R lacks the acrylamide warhead and therefore cannot form a covalent bond with the kinase. SM1-71-R can be used as a control compound for SM1-71 ^[1].

HY-N10805

Schisanlignone C	Others	Others
Schisanlignone C is a chemical component of Schisandra viridis a. c. sm .

HY-155176

SP-2-225	HDAC	Cancer
SP-2-225 is a selective HDAC6 inhibitor. SP-2-225 enhance the production of cancer-associated antigens and macrophage antigen cross-presentation to T cells. SP-2-225 reduces the tumor volume in a syngeneic SM1 melanoma model ^[1].

HY-178110

HDAC6-IN-65	HDAC Microtubule/Tubulin Histone Methyltransferase	Cancer
HDAC6-IN-65 is a selective HDAC6 inhibitor (IC₅₀ = 0.9 nM) and also exhibits a certain suppressive effect on HDAC3 (IC₅₀ = 39.4 nM). HDAC6-IN-65 can induce the accumulation of α-tubulin (ac-tubulin) and acetylated histone H3 (ac-histone H3, a class I HDAC inhibition marker) in Neuro-2a cells. HDAC6-IN-65 can be used for the study of melanoma ^[1].

HY-N2836

Alepterolic acid	Others	Others
Alepterolic acid is a Diterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N10806

Schisanlignone D	Others	Others
Schisanlignone D is a chemical component of Schisandra viridis a. c. sm .

HY-N3833

Epipterosin L	Others	Others
Epipterosin L is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N1573

Pterosin Z	Others	Others
Pterosin Z is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N3834

Epipterosin L 2'-O-glucoside	Others	Others
Epipterosin L 2'-O-glucoside is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N1572

Pterosin D 3-O-glucoside	Others	Others
Pterosin D 3-O-glucoside is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N1808

3-Acetoxy-8(17),13E-labdadien-15-oic acid	Others	Others
3-Acetoxy-8(17),13E-labdadien-15-oic acid is a Diterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N8881

Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate Jacaranone ethyl ester	Others	Others
Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate (Jacaranone ethyl ester) is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990131

Anti-Mouse CD47/IAP Antibody (MIAP301) 1 Publications Verification	CD47	Infection Inflammation/Immunology Cancer
Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse CD47/IAP IgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis ^[1] .

Schisanlignone C	Terpenoids Lignans Phenylpropanoids Plants Schisandraceae Schisandra viridis A. C. Smith Source Classification	Others
Schisanlignone C is a chemical component of Schisandra viridis a. c. sm .

Alepterolic acid	Terpenoids Distephanus angulifolius (DC.) H.Rob. & B.Kahn Diterpenoids Cibotiaceae Plants Source Classification	Others
Alepterolic acid is a Diterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

Schisanlignone D	Plants Schisandraceae Schisandra viridis A. C. Smith Source Classification	Others
Schisanlignone D is a chemical component of Schisandra viridis a. c. sm .

Epipterosin L	Structural Classification Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Cibotiaceae Plants Source Classification	Others
Epipterosin L is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

Pterosin Z	Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Cibotiaceae Plants Source Classification	Others
Pterosin Z is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

Epipterosin L 2'-O-glucoside	Structural Classification Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Cibotiaceae Plants Source Classification	Others
Epipterosin L 2'-O-glucoside is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

Pterosin D 3-O-glucoside	Terpenoids Sesquiterpenes Distephanus angulifolius (DC.) H.Rob. & B.Kahn Cibotiaceae Plants Source Classification	Others
Pterosin D 3-O-glucoside is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

3-Acetoxy-8(17),13E-labdadien-15-oic acid	Terpenoids Distephanus angulifolius (DC.) H.Rob. & B.Kahn Diterpenoids Cibotiaceae Plants Source Classification	Others
3-Acetoxy-8(17),13E-labdadien-15-oic acid is a Diterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate Jacaranone ethyl ester	Quinones Erinacea anthyllis Link Benzene Quinones Plants Compositae Source Classification	Others
Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate (Jacaranone ethyl ester) is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

SM1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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SM1

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Oligonucleotides

Natural
Products