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Results for "

SU-DHL-6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Apoptosis (10) Autophagy (1) Bcl-2 Family (1) Bcr-Abl (1) Btk (1) Caspase (1) Deubiquitinase (1) HDAC (1) Histone Methyltransferase (18) IAP (2) MDM-2/p53 (1) Microtubule/Tubulin (2) PI3K (10) PROTACs (18) Reactive Oxygen Species (ROS) (1) Src (1)
By Research Areas:	Cancer (30) Inflammation/Immunology (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157164

PROTAC EZH2 Degrader-2 1 Publications Verification	PROTACs Histone Methyltransferase Apoptosis	Cancer
PROTAC EZH2 Degrader-2 is a PROTAC EZH2 inhibitor. PROTAC EZH2 Degrader-2 degrades EZH2 in SU-DHL-6 cells in a dose-dependent manner. PROTAC EZH2 Degrader-2 induces apoptosis and reduces mitochondrial membrane potential in SU-DHL-6 cells. PROTAC EZH2 Degrader-2 has anti-cancer and anti-proliferative activity .

HY-148369

U7D-1	PROTACs Deubiquitinase Apoptosis MDM-2/p53	Cancer
U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC₅₀ of 33 nM in RS4;11 cells. U7D-1 shows anticancer activity. U7D-1 induces apoptosis in Jeko-1 cells .

HY-176239

PROTAC PI3Kδ degrader-1	PROTACs PI3K Akt Apoptosis Autophagy	Cancer
PROTAC PI3Kδ degrader-1 is a Lysine-targeted covalent PI3Kδ PROTAC degrader with a DC₅₀ of 3.98 nM. PROTAC PI3Kδ degrader-1 has a potent antiproliferative activity and selective PI3Kδ inhibition (IC₅₀: 8 nM). PROTAC PI3Kδ degrader-1 also significantly degrades p-AKT, induces cell cycle arrest in G1 phase and prompts cell apoptosis and autophagy. PROTAC PI3Kδ degrader-1 effectively inhibits the tumor growth in SU-DHL-6 xenograft mice model . Pink: PI3Kδ ligand (HY-169983); Blue: VHL ligase ligand (HY-112078); Black: linker (HY-W013381)

HY-142676

PI3K-IN-26	PI3K	Inflammation/Immunology Cancer
PI3K-IN-26 is a potent PI3K inhibitor with an IC₅₀ of 36 nM for SU-DHL-6 cells (WO2016066142A1, compound 1) .

HY-149634

PI3Kδ-IN-17	PI3K	Cancer
PI3Kδ-IN-17 (Compound S5) is a potent inhibitor of PI3Kδ, with IC₅₀ of 2.82?nM. PI3Kδ-IN-17 shows strong inhibitory activity of proliferation in SU-DHL-6 cells (IC₅₀ = 0.035 μM) .

HY-174396

PI3Kδ/HDAC6-IN-1	PI3K HDAC Bcl-2 Family Caspase Reactive Oxygen Species (ROS) Apoptosis Histone Methyltransferase Microtubule/Tubulin	Cancer
PI3Kδ/HDAC6-IN-1 (Compound 22E) is an orally active and dual inhibitor of PI3Kδ and *HDAC6* with IC₅₀ values of 2.4 nM and 6.2 nM, respectively. PI3Kδ/HDAC6-IN-1 exhibits potent antiproliferative effects on non-Hodgkin lymphoma (NHL) cells and possesses in vivo antitumor activity without significant toxicity. PI3Kδ/HDAC6-IN-1 arrests the cell cycle at the G0/G1 phase and induces apoptosis. PI3Kδ/HDAC6-IN-1 blocks the PI3K/AKT/mTOR signaling pathway and increases the acetylation levels of α-tubulin and histone H3 .

HY-155232

PI3Kδ-IN-16	PI3K Apoptosis	Cancer
PI3Kδ-IN-16 is a potent and selective PI3Kδ inhibitor with an IC₅₀ value of 0.9 nM. PI3Kδ-IN-16 has a strong anti-proliferative effect on SU-DHL-6 cells, causing cell cycle arrest and inducing apoptosis. PI3Kδ-IN-16 tightly bins to PI3Kδ protein with a planar-shaped conformation. The kinase activity of PI3Kδ-IN-16 which is ~378-fold over PI3Kα, 412-fold over PI3Kβ, and 10-fold over PI3Kγ. PI3Kδ-IN-16 can be used for the study of hematologic malignancies .

HY-181412

PROTAC EZH2 Degrader-43	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-43 (compound 59) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 21.73 μM against SU-DHL-6 cells. PROTAC EZH2 Degrader-43 can be used for the research of lymphoma .

HY-181409

PROTAC EZH2 Degrader-40	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-40 (compound 56) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 15.35 μM against SU-DHL-6 cells. PROTAC EZH2 Degrader-40 can be used for the research of diffuse large B-cell lymphoma .

HY-181414

PROTAC EZH2 Degrader-45	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-45 (compound 61) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 22.97 μM in SU-DHL-6 cells. PROTAC EZH2 Degrader-45 can be used for the research of diffuse large b-cell lymphoma .

HY-181359

PROTAC EZH2 Degrader-30	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-30 (compound 67) is ais a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 6.22 μM against SU-DHL-6 cells. PROTAC EZH2 Degrader-30 can be used for the research of diffuse large B-cell lymphoma .

HY-181296

PROTAC EZH2 Degrader-16	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-16 (compound 51) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 13.74 μM in SU-DHL-6 cells. PROTAC EZH2 Degrader-16 exerts antiproliferative activity against diffuse large B-cell lymphoma cells. PROTAC EZH2 Degrader-16 can be used for the research of diffuse large B-cell lymphoma .

HY-169983

PI3Kδ-IN-23	PI3K	Cancer
PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with the IC₅₀ of 0.27 nM. PI3Kδ-IN-23 bounds to PI3Kδ by covalent-bonding interactions with Lys779. PI3Kδ-IN-23 plays an important role in cancer research .

HY-145762

YM281	Apoptosis Histone Methyltransferase	Cancer
YM281 is a potent EZH2 inhibitor. YM281 induces cell apoptosis and cell cycle arrest at the G0/G1 phase. YM281 shows antitumor effects in vivo. YM281 has the potential for the research of lymphoma .

HY-175002

PI3Kδ-IN-24	PI3K Akt Apoptosis	Cancer
PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC₅₀ = 0.1 nM). PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL) .

HY-146789

PI3Kδ/γ-IN-2	PI3K	Cancer
PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC₅₀s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies .

HY-150511

3-(3-Phenoxybenzyl)amino-β-carboline	Microtubule/Tubulin Apoptosis	Cancer
3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity .

HY-180192

Dehydroxy-oridonin-vinyl ester	PI3K Akt Apoptosis	Cancer
Dehydroxy-oridonin-vinyl ester (Compound 6k) is an anti-cancer agent. Dehydroxy-oridonin-vinyl ester exhibits extremely strong anti-proliferative activity against SU-DHL-6 cells, with its IC₅₀ value being 0.12 μM. Dehydroxy-oridonin-vinyl ester induces cell apoptosis by inhibiting the activation of the PI3K/Akt signaling pathway, without affecting the cell cycle progression. Dehydroxy-oridonin-vinyl can be used for the study of lymphoma .

HY-163538

TYM-3-98	PI3K Apoptosis	Cancer
TYM-3-98 is a selective inhibitor for PI3Kδ, with an IC₅₀ of 7.1 nM. TYM-3-98 inhibits proliferationso of B-lymphoma cells. TYM-3-98 inhibits PI3K/AKT/mTOR signaling pathway through induction of apoptosis. TYM-3-98 exhibits good pahrmacokinetic characters and antitumor efficacy in mouse/rat model, without significant toxicity .

HY-181360

PROTAC EZH2 Degrader-31	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-31(compound 69) is a PROTAC protein degrader targeting EZH2, with antiproliferative IC₅₀ values of 3.63 μM in lSU-DHL-6 cells and 8.74 μM in HBL-1 cells. PROTAC EZH2 Degrader-31 can be used for the research of lymphoma .

HY-181301

PROTAC EZH2 Degrader-18	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-18 (compound E-CH2-B4) is a PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-18 is applicable to lymphoma-related research .

HY-181295

PROTAC EZH2 Degrader-14	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-14 is an EZH2 PROTAC degrader, with an IC₅₀ of 18.21 μM against diffuse large B-cell lymphoma cells, and exhibits no antiproliferative activity against non-target cells at concentrations up to 30.00 μM. PROTAC EZH2 Degrader-14 can be used in studies related to diffuse large B-cell lymphoma .

HY-181300

PROTAC EZH2 Degrader-17	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-17 (compound 52) is a PROTAC protein degrader targeting EZH2 with an antiproliferative IC₅₀ of 18.32 μM in lymphoma cells. PROTAC EZH2 Degrader-17 exhibits antiproliferative activity against lymphoma cells. PROTAC EZH2 Degrader-17 can be used for the research of lymphoma .

HY-183103

PDD-87	Bcr-Abl Src Btk	Cancer
PDD-87 is an orally active, blood-brain barrier permeable kinase inhibitor, with IC₅₀ values ranging from 0.07 nM to 0.72 nM against ABL, SRC family, BTK kinases and their key mutants. PDD-87 induces antiproliferative effects in leukemia and lymphoma cells, and inhibits tumor growth in mouse xenograft models. PDD-87 can be used for the research of leukemia and lymphoma .

HY-181355

PROTAC EZH2 Degrader-28	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-28 (compound 66) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 16.2 μM against diffuse large B-cell lymphoma cells. PROTAC EZH2 Degrader-28 can be used for the research of lymphoma .

HY-181319

PROTAC EZH2 Degrader-21	PROTACs Histone Methyltransferase IAP	Cancer
PROTAC EZH2 Degrader-21 is an EZH2 degrader developed based on PROTAC technology. PROTAC EZH2 Degrader-21 induces the degradation of the target protein EZH2 via specific recruitment of the cIAP E3 ligase. PROTAC EZH2 Degrader-21 exhibits significant inhibitory activity in a variety of lymphoma cell lines. PROTAC EZH2 Degrader-21 can be used for research on the pathogenesis of lymphoma .

HY-181318

PROTAC EZH2 Degrader-20	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-20 (compound 54) is an EZH2-target PROTAC degrader with antiproliferative activity and IC₅₀ values of about 10 μM against lymphoma cells. PROTAC EZH2 Degrader-20 can be used for the research of lymphoma .

HY-181357

PROTAC EZH2 Degrader-29	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-29 (compound 66) is a is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 24.53 μM against diffuse large B-cell lymphoma cells. PROTAC EZH2 Degrader-29 can be used in studies related to diffuse large B-cell lymphoma .

HY-181411

PROTAC EZH2 Degrader-42	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-42 (compound 57) is an EZH2-targeting PROTAC degrader and antiproliferative agent. PROTAC EZH2 Degrader-42 induces cIAP-mediated ubiquitination and subsequent proteasomal degradation of EZH2. PROTAC EZH2 Degrader-42 can be used for the research of lymphoma .

HY-181410

PROTAC EZH2 Degrader-41	PROTACs Histone Methyltransferase IAP	Cancer
PROTAC EZH2 Degrader-41 is an EZH2-targeting PROTAC and cIAP E3 ubiquitin ligase recruiter. PROTAC EZH2 Degrader-41 induces EZH2 degradation via ubiquitination and proteasomal breakdown. PROTAC EZH2 Degrader-41 exerts antiproliferative effects in lymphoma cells. PROTAC EZH2 Degrader-41 can be used for the research of lymphoma .

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SU-DHL-6

Inhibitors & Agonists