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Cat. No.: HY-181296

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PROTAC EZH2 Degrader-16

PROTAC EZH2 Degrader-16 (compound 51) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 13.74 μM in SU-DHL-6 cells. PROTAC EZH2 Degrader-16 exerts antiproliferative activity against diffuse large B-cell lymphoma cells. PROTAC EZH2 Degrader-16 can be used for the research of diffuse large B-cell lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3093642-22-6
Formula: C₆₀H₇₅N₁₁O₁₂
Molecular Weight:1142.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC EZH2 Degrader-16 Chemical Structure

CAS No.: 3093642-22-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

PROTAC EZH2 Degrader-16 (compound 51) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 13.74 μM in SU-DHL-6 cells. PROTAC EZH2 Degrader-16 exerts antiproliferative activity against diffuse large B-cell lymphoma cells. PROTAC EZH2 Degrader-16 can be used for the research of diffuse large B-cell lymphoma^[1]. (Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-14658); Black: linker).

All PROTACs Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

PROTAC EZH2 Degrader-16 (compound 51)inhibits the proliferation of SU-DHL-6 cells with an IC₅₀ of 13.74 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3093642-22-6
Molecular Weight 1142.30
Formula C₆₀H₇₅N₁₁O₁₂
SMILES

CCN(C1=CC(C2=CC=C(CN3CCN(C(C4=CN(N=N4)CCOCCOCCOCCOCCNC5=C6C(C(N(C6=O)C7CCC(NC7=O)=O)=O)=CC=C5)=O)CC3)C=C2)=CC(C(NCC8=C(C)C=C(C)NC8=O)=O)=C1C)C9CCOCC9
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H, et al. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026;16(4):3034-3056. Published 2026 Jan 14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC EZH2 Degrader-16

All PROTACs Isoforms

All Histone Methyltransferase Isoforms