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Cat. No.: HY-181414

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PROTAC EZH2 Degrader-45

PROTAC EZH2 Degrader-45 (compound 61) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 22.97 μM in SU-DHL-6 cells. PROTAC EZH2 Degrader-45 can be used for the research of diffuse large b-cell lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: VHL ligand (HY-112078A); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3093642-26-0
Formula: C₆₂H₇₈N₁₂O₈S
Molecular Weight:1151.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC EZH2 Degrader-45 Chemical Structure

CAS No.: 3093642-26-0

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Fluorescent Dye

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- In Vitro
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Biological Activity

Description

PROTAC EZH2 Degrader-45 (compound 61) is a PROTAC protein degrader targeting EZH2 with an IC₅₀ of 22.97 μM in SU-DHL-6 cells. PROTAC EZH2 Degrader-45 can be used for the research of diffuse large b-cell lymphoma^[1]. (Pink: EZH2 ligand (HY-147230); Blue: VHL ligand (HY-112078A); Black: linker).

All PROTACs Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

PROTAC EZH2 Degrader-45 (compound 61) (up to 30 μM) inhibits EZH2 enzymatic activity in SU-DHL-6 cells with an IC₅₀ of 22.97 μM and does not exhibit measurable cytotoxicity in HBL-1 cells at concentrations up to 30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3093642-26-0
Molecular Weight 1151.42
Formula C₆₂H₇₈N₁₂O₈S
SMILES

CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)C(C5=CN(N=N5)CC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@@H](C7=CC=C(C8=C(C)N=CS8)C=C7)C)=O)=O)=O)=O)=CC(C(NCC9=C(C=C(NC9=O)C)C)=O)=C2C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H, et al. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026;16(4):3034-3056. Published 2026 Jan 14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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PROTAC EZH2 Degrader-45

All PROTACs Isoforms

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC EZH2 Degrader-45 Related Classifications

HY-181414 Related Classifications