2 Results for "

Seglitide

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Seglitide" in MCE Product Catalog:

Seglitide
Seglitide
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Cat. No.: HY-106103
CAS No.: 81377-02-8
Purity:  99.30%
Synonyms: MK-678; L-363586
Target:  

Somatostatin Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology

Seglitide (MK-678) is an orally active, selective SSTR2 agonist and somatostatin analog. Seglitide also acts as a competitive Somatostatin receptor antagonist, with pA2 values of 6.50, 6.24 and 6.09 against SS14, SS25 and SS28, respectively. Seglitide produces only weak, transient inhibition of myocardial contractility in isolated right atria of guinea pigs. Seglitide inhibits glucagon secretion and reduces circulating insulin levels. Seglitide causes a sustained, reversible reduction in elevated systolic blood pressure in streptozotocin (HY-13753)-induced diabetic rats, but exerts no effect on spontaneously hypertensive rats. Seglitide induces membrane hyperpolarization and inhibits electrical excitability. Seglitide induces concentration-dependent contraction and significant desensitization in isolated distal colon of rats. Seglitide can be used in research related to hypertension complicated with insulin-dependent diabetes mellitus .
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Seglitide acetate
Seglitide acetate
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Cat. No.: HY-106103A
CAS No.: 99248-33-6
Purity:  99.30%
Synonyms: MK 678 acetate; L 36358 acetate
Target:  

Somatostatin Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease

Seglitide acetate (MK 678; L 36358 acetate) is a potent, orally active somatostatin receptor 2 (SSTR2) agonist, and also a competitive antagonist of SSTR14, SSTR25, and SSTR28. Seglitide acetate has antihypertensive effects and can inhibit plasma glucagon and growth hormone. Seglitide acetate can be used for research on diabetes .
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