Search Result

Results for "

Snail

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (3) AMPK (1) Amyloid-β (1) Antibiotic (1) Apoptosis (5) ATM/ATR (1) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (2) Cadherin (2) Chloride Channel (1) Cholinesterase (ChE) (1) CXCR (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Environmental Pollutants (2) Epigenetic Reader Domain (1) ERK (2) FAK (1) Ferroptosis (1) FGFR (1) Fungal (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) iGluR (1) Insecticide (3) JAK (2) JNK (1) Kallikrein (1) MDM-2/p53 (1) MMP (1) mTOR (3) Na+/K+ ATPase (1) NF-κB (1) Notch (1) PAK (1) Parasite (1) PI3K (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) Proteasome (1) PTEN (1) Pyruvate Carboxylase (PC) (1) Reference Standards (1) Reverse Transcriptase (1) Small Interfering RNA (siRNA) (2) STAT (1) VEGFR (1) Wnt (1) β-catenin (2) γ-secretase (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (6)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142870

ZY-444	Pyruvate Carboxylase (PC) Apoptosis β-catenin ERK Wnt	Cancer
ZY-444 is an anti-cancer agent, targeting pyruvate carboxylase (PC). ZY-444 suppresses the *Wnt/β-catenin/Snail* signaling pathway by blocking nuclear translocation of β-catenin. ZY-444 selectively inhibits proliferation, migration, and invasion and induces apoptosis in cancer cells. ZY-444 exhibits potent anti-tumor in cancer mouse models. ZY-444 can be used for the study of breast cancer, lung cancer (NSCLC), prostate cancer and iodine-refractory thyroid cancer .

HY-Y0261A

Ammonium sulphate,≥99.0%,AR	Environmental Pollutants Biochemical Assay Reagents	Others
Ammonium sulphate,≥99.0%,AR is an inorganic sulfate salt used for molecular biology . Ammonium sulphate,≥99.0%,AR can be used to precipitate proteins, separate antibodies, and enhance antigen-antibody reactions. Ammonium sulphate,≥99.0%,AR can serve as a nitrogen source in plant fertilizers and has developmentally toxicity to freshwater snails, but increases the number of Anopheles africanus and Culex mosquito larvae in rice paddies. Ammonium sulphate,≥99.0%,AR also inhibits the conversion of glucose to ascorbic acid in plants .

HY-144315

CYD19 Snail/HDAC-IN-1	HDAC	Cancer
CYD19 is a potent *Snail/HDAC* dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC₅₀ of 0.405 μM and potent inhibition against Snail with a K_d of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis .

HY-E70130

*Snailase, Snail* gastrointestinal**	Others	Others
Snailase, Snail gastrointestinal is an enzyme mixture composed of more than 20 enzymes, which is often used for enzymatic hydrolysis of purified flavonoid glycosides. Snailase can be obtained from the digestive tract and includes cellulase, sucrase, hemicellulase, pectinase, polygalacturonase, protease, etc .

HY-117280

GN25	MDM-2/p53	Cancer
GN25 is a specific *p53-Snail* binding** inhibitor with antitumor effects .

HY-B1647

Ferric phosphate	Insecticide	Others
Ferric phosphate is used as food and feed supplement, particularly in bread enrichment. Ferric phosphate is also used as a fertilizer and as a molluscicide for a variety of slugs and snails including Deroceras reticulatum, D.laeve, Arion subfuscus .

HY-162153

CYY292	FGFR	Cancer
CYY292 is an FGFR1 inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro .

HY-157435

PELI1-IN-1	E1/E2/E3 Enzyme Cytochrome P450 Proteasome	Cancer
PELI1-IN-1 (compound 3d) is a potent inhibitor of PELI1, E3 ubiquitin ligase. PELI1-IN-1 has anti-tumPELI1-IN-1, a Resveratrol (HY-16561) derivative, is an orally active PELI1 Inhibitor (K_d = 8.2 μM). PELI1-IN-1 markedly interrupts the interaction of PELI1 and SNAIL/SLUG, and inhibits the K63-polyubiquitization of SNAIL/SLUG by PELI1, subsequently downregulating the protein levels of epithelial-mesenchymal transition (EMT) effectors SNAIL/SLUG. PELI1-IN-1 significantly reduces the level of SNAIL, SLUG and Vimentin without affecting the PELI1 expression. PELI1-IN-1 targets the FHA domain of PELI1 and disrupts the interaction, leading to the anti-metastasis of TNBC cells in vitro and in vivo. PELI1-IN-1 shows no evident toxicity in vivo .

HY-N0885

Telocinobufagin 1 Publications Verification Telobufotoxin; Telocinobufogenin	JAK STAT mTOR PI3K Akt Polo-like Kinase (PLK) Na+/K+ ATPase Apoptosis Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, *PI3K/Akt/Snail* and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na ⁺/K ⁺-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models .

HY-B1870

Metaldehyde	Environmental Pollutants Insecticide	Infection
Metaldehyde is a commonly used pesticide for mollusks such as slugs and snails.

HY-RS13470

SNAI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SNAI1 Human Pre-designed siRNA Set A contains three designed siRNAs for SNAI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SNAI1 Human Pre-designed siRNA Set A SNAI1 Human Pre-designed siRNA Set A

HY-N10449

Resistomycin	Antibiotic Apoptosis Bacterial	Cancer
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

HY-N11709

Theasaponin E1	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal	Infection Neurological Disease Metabolic Disease Cancer
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .

HY-159130

AO-022	DNA/RNA Synthesis	Cancer
AO-022 is a potent TALDO1 allosteric inhibitor. AO-022 decreases the expression of vimentin and snail. AO-022 shows antiproliferative activity and antitumor activity. AO-022 has the potential for the research of breast cancer .

HY-P1287

Conantokin-T	iGluR	Neurological Disease
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC₅₀ value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa .

HY-P11082

APGW-amide	Endogenous Metabolite	Neurological Disease
APGW-amide is a neuropeptide. APGW-amide controls the growth of imposex structures and promotes growth in Haliotis asinina. APGW-amide inhibits Achatina neurons and modulates neuronal currents induced by neuroactive compounds. APGW-amide induces a rapid increase in [Ca ²⁺]_i in Fura-2/AM-loaded PC12 cells. APGW-amide is useful for research on the nervous system .

HY-142074

Inophyllum B (+)-Inophyllum B	Reverse Transcriptase HIV	Infection
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits HIV-1 (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .

HY-146681

PAK1-IN-1	PAK	Cancer
PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC₅₀ of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner .

HY-N15267

Ovalitenone	FAK Akt mTOR	Cancer
Ovalitenone is a flavonoid compound that can be isolated from the plant Millettia peguensis. It shows no cytotoxic effects on lung cancer H460 and A549 cells, but it significantly inhibits anchorage-independent growth, CSC-like phenotypes, colony formation, and the migration and invasion capabilities of cancer cells. Ovalitenone can significantly reduce the levels of N-cadherin, snail, and slug, while increasing E-cadherin, thus inhibiting the EMT pathway. Additionally, Ovalitenone suppresses the signaling pathways regulated by focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42) .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs .

HY-126106

(BrMT)2	Potassium Channel	Others
(BrMT)2 (compound 2) is a non-peptide snail toxin that slows down the activation of Kv1.1 channels .

HY-174441

Molluscicidal agent-2	Chloride Channel	Others
Molluscicidal agent-2 (Compound 16) is a molluscicide with an LC₅₀ of 0.58 mg/mL against Monacha cartusiana snails. Molluscicidal agent-2 exerts its effect through a dual mode of action: gastrointestinal toxicity and GABA_A-GluCl channel antagonism. Molluscicidal agent-2 can be used in research on agricultural pest control .

HY-181654

Snail IN-1	Epigenetic Reader Domain CXCR MMP	Inflammation/Immunology
Snail IN-1 is an orally active *Snail* inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts *Snail-CBP* interaction, accelerates *Snail* protein degradation, reduces *Snail* acetylation, increases *Snail* polyubiquitination, and selectively downregulates *Snail* protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis .

HY-RS19742

Snai1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Snai1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Snai1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Snai1 Mouse Pre-designed siRNA Set A Snai1 Mouse Pre-designed siRNA Set A

HY-B1870R

Metaldehyde (Standard)	Insecticide Reference Standards	Infection
Metaldehyde (Standard) is the analytical standard of Metaldehyde. This product is intended for research and analytical applications. Metaldehyde is a commonly used pesticide for mollusks such as slugs and snails.

HY-N0531

Filixic acid ABA	Parasite	Infection
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an LD₅₀ of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-150596

CT1-3	Apoptosis Bcl-2 Family JNK	Cancer
CT1-3 is a potent anticancer agent. CT1-3 induces mitochondria-mediated apoptosis by regulating JNK/Bcl-2/Bax/XIAP pathway. CT1-3 suppresses the epithelial mesenchymal transition (EMT) potential of human cancer cells (HCCs) via regulating the E-cadherin/Snail axis, thus inhibits tumorigenesis. CT1-3 has a strong antitumor effect in mice model and exhibits no significant hepatic and renal toxicity .

HY-NP186

Helix pomatia Agglutinin	Biochemical Assay Reagents	Cancer
Helix pomatia Agglutinin is a N-acetylgalactosamine (GalNAc) binding lectin, found in the reproductive gland of a Roman snail. Helix pomatia Agglutinin binds with high affinity (k_D = 1.9-2.4 μM) steroid hormones: testosterone and progesterone. Helix pomatia Agglutinin interacts with adenine (k_D = 5.4 μM) and arylaminonaphthalene sulfonate TNS (k_D = 12 μM). Helix pomatia Agglutinin is commonly used for characterizing, imaging, or targeting glycoconjugates, and is also a very useful tool for glycomics analysis . Helix pomatia Agglutinin can be used for cancer prognosis study .

HY-N16719

Picrasidine J	Kallikrein ERK Cadherin β-catenin	Cancer
Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and *Snail*, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors .

HY-182361

NUAK1-IN-3	AMPK JAK Cadherin	Cancer
NUAK1-IN-3 is a potent and selective NUAK1 inhibitor with an IC₅₀ of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC₅₀ values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1, forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates MYPT1 phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates *Snail* and N-cadherin, and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer .

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library	61 compounds
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 61 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Marine-Sourced Natural Product Library

61 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 61 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Type

HY-B1647

Ferric phosphate	Biochemical Assay Reagents
Ferric phosphate is used as food and feed supplement, particularly in bread enrichment. Ferric phosphate is also used as a fertilizer and as a molluscicide for a variety of slugs and snails including Deroceras reticulatum, D.laeve, Arion subfuscus .

HY-NP186

Helix pomatia Agglutinin	Biochemical Assay Reagents
Helix pomatia Agglutinin is a N-acetylgalactosamine (GalNAc) binding lectin, found in the reproductive gland of a Roman snail. Helix pomatia Agglutinin binds with high affinity (k_D = 1.9-2.4 μM) steroid hormones: testosterone and progesterone. Helix pomatia Agglutinin interacts with adenine (k_D = 5.4 μM) and arylaminonaphthalene sulfonate TNS (k_D = 12 μM). Helix pomatia Agglutinin is commonly used for characterizing, imaging, or targeting glycoconjugates, and is also a very useful tool for glycomics analysis . Helix pomatia Agglutinin can be used for cancer prognosis study .

Helix pomatia Agglutinin

Biochemical Assay Reagents

Helix pomatia Agglutinin is a N-acetylgalactosamine (GalNAc) binding lectin, found in the reproductive gland of a Roman snail. Helix pomatia Agglutinin binds with high affinity (k_D = 1.9-2.4 μM) steroid hormones: testosterone and progesterone. Helix pomatia Agglutinin interacts with adenine (k_D = 5.4 μM) and arylaminonaphthalene sulfonate TNS (k_D = 12 μM). Helix pomatia Agglutinin is commonly used for characterizing, imaging, or targeting glycoconjugates, and is also a very useful tool for glycomics analysis . Helix pomatia Agglutinin can be used for cancer prognosis study .

Cat. No.	Product Name	Target	Research Area

HY-P1904

*Phe-Met-Arg-Phe Like Peptide, Snail* Helix aspersa**	Peptides	Neurological Disease
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues .

HY-P5166

Lys-Conopressin-G	Peptides	Others
Lys-Conopressin-G, a vasotocin-like peptide, can be isolated from the venom of the worm-hunting snail (conus imperialis) .

HY-P1287

Conantokin-T	iGluR	Neurological Disease
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC₅₀ value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa .

HY-P11082

APGW-amide	Endogenous Metabolite	Neurological Disease
APGW-amide is a neuropeptide. APGW-amide controls the growth of imposex structures and promotes growth in Haliotis asinina. APGW-amide inhibits Achatina neurons and modulates neuronal currents induced by neuroactive compounds. APGW-amide induces a rapid increase in [Ca ²⁺]_i in Fura-2/AM-loaded PC12 cells. APGW-amide is useful for research on the nervous system .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs .

HY-P2084

WWamide-1	Peptides	Neurological Disease
WWamide-1 is a neuropeptide, which can be isolated form Achatina fulica. WWamide-1 inhibits central neurons of snails, regulates the snail muscle contraction. WWamide-1 inhibits the contraction of anterior byssus retractor muscle (ABRM), enhances the contraction of the radular traction muscle, through effects on presynaptic and postsynaptic membrane of the muscle .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0885

Telocinobufagin 1 Publications Verification Telobufotoxin; Telocinobufogenin	Structural Classification Animals Classification of Application Fields Other Diseases Disease Research Fields Steroids Source Classification	JAK STAT mTOR PI3K Akt Polo-like Kinase (PLK) Na+/K+ ATPase Apoptosis Bacterial
Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, *PI3K/Akt/Snail* and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na ⁺/K ⁺-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models .

HY-P1904

*Phe-Met-Arg-Phe Like Peptide, Snail* Helix aspersa**	Natural Products Animals Source Classification	Others
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues .

HY-N10449

Resistomycin	Microorganisms Phenols Polyphenols Source Classification	Antibiotic Apoptosis Bacterial
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .

HY-142074

Inophyllum B (+)-Inophyllum B	Rosaceae Coumarins Phenylpropanoids Plants Photinia serratifolia (Desf.) Kalkman Source Classification	Reverse Transcriptase HIV
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits HIV-1 (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .

HY-N15267

Ovalitenone	Natural Products Millettia peguensis Ali Leguminosae Plants Source Classification	FAK Akt mTOR
Ovalitenone is a flavonoid compound that can be isolated from the plant Millettia peguensis. It shows no cytotoxic effects on lung cancer H460 and A549 cells, but it significantly inhibits anchorage-independent growth, CSC-like phenotypes, colony formation, and the migration and invasion capabilities of cancer cells. Ovalitenone can significantly reduce the levels of N-cadherin, snail, and slug, while increasing E-cadherin, thus inhibiting the EMT pathway. Additionally, Ovalitenone suppresses the signaling pathways regulated by focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42) .

HY-N0531

Filixic acid ABA	Infection Quinones Urticaceae Classification of Application Fields Debregeasia wallichiana (Wedd.) Wedd. Phenols Polyphenols Benzene Quinones Plants Disease Research Fields Source Classification	Parasite
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an LD₅₀ of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-N16719

Picrasidine J	Structural Classification Alkaloids Simaroubaceae Plants Picrasma quassioides(D．Don)Benn． Indole Alkaloids Source Classification	Kallikrein ERK Cadherin β-catenin
Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and *Snail*, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors .

Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (6) Mouse (2) Monkey (1)
Application:	IHC-P (3) ICC/IF (4) IP (1) WB (6) FC (2) ELISA (5)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (6)
Clonality:	Polyclonal (1) Monoclonal (4)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81135

	SNAI1 Antibody 1 Publications Verification SNAI1_HUMAN; Zinc finger protein SNAI1; SNAI1; SNAH; SNAI 1; SNA; Snail1; dJ710H13.1; Protein Snail homolog 1 (Protein sna); Protein Snail homolog 1; Protein sna;	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey
	SNAI1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SNAI1.

HY-P83845

	SLUG Antibody (YA3542) SLUG; WS2D; SLUGH1; Snail2	WB, IHC-P, ICC/IF, FC, ELISA	Human
	SLUG Antibody (YA3542) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLUG.

HY-P83845A

	SLUG Antibody (YA3542)(PBS only) SLUG; WS2D; SLUGH1; Snail2	WB, IHC-P, ICC/IF, FC, ELISA	Human
	SLUG Antibody (YA3542) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLUG.

HY-P86359

	SLUG Antibody (YA6051) Zinc finger protein SNAI2 (Neural crest transcription factor Slug; Protein Snail homolog 2)	WB, ICC/IF, IP, ELISA	Human, Mouse
	SLUG Antibody (YA6051) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLUG.

HY-P85372

	SNAI1 Antibody (YA5064) SNAI1; SNAH; Zinc finger protein SNAI1; Protein Snail homolog 1; Protein sna	WB	Human
	SNAI1 Antibody (YA5064) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SNAI1.

HY-P85368

	SLUG Antibody (YA5060) SNAI2; SLUG; SLUGH; Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein Snail homolog 2	WB, ELISA	Human
	SLUG Antibody (YA5060) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SLUG.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Snail

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Antibodies

Oligonucleotides

Natural
Products