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TA100

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (10) Biochemical Assay Reagents (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (3) Endogenous Metabolite (1) Endothelin Receptor (1) Environmental Pollutants (1) Histone Demethylase (1) Histone Methyltransferase (1) Insecticide (1) Isotope-Labeled Compounds (1) Parasite (1) Reference Standards (2) RUNX (1) TNF Receptor (1) VEGFR (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (13) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Z0275

HOAT	Biochemical Assay Reagents Bacterial	Infection
HOAT is a peptide bond-forming reagent. HOAT is utilized to affect formation of peptide bonds by coupling carboxylic acids with amines. HOAt is not mutagenic in the bacterial reverse mutation test .

HY-W275553

4-Decanol	DNA Alkylator/Crosslinker	Infection
4-Decanol is an antimutagenic compound, that can be isolated from mustard leaves. 4-Decanol inhibits mutagenic activities of Aflatoxin B1 (HY-N6615) and MNNG (HY-128612) in Salmonella typhimurium TA100 .

HY-W001189

1,3-Dithiane	Bacterial	Infection
1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-W008030

3-Aminobiphenyl	Bacterial	Infection
3-Aminobiphenyl is a chemical isomer of 4-ABP. 3-Aminobiphenyl can inhibit the growth of human intestinal bacteria Bifidobacterium infantis ATCC 15697, B. bifidium ATCC 11863, Clostridium perfringens ATCC 13124, Escherichia coli ATCC 25922, E. coli ATCC 35218, Enterobacter cloacae ATCC 13047 and Salmonella typhimurium TA98, TA100, YG1041. 3-Aminobiphenyl can be used as a biomarker of exposure to aromatic amines from cigarette smoke .

HY-N5054

(R)-5,7-Dimethoxyflavanone	TNF Receptor	Inflammation/Immunology
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-W075176

Transfluthrin	Insecticide	Infection
Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. It acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as Azovibrio and Tauera .

HY-W150695

1-Acetamidonaphthalene N-(Naphthalen-1-yl)aceTAmide	Bacterial	Infection
1-Acetamidonaphthalene (N-(Naphthalen-1-yl)acetamide) is a degradation product of Digitoxigenin (HY-B2151). 1-Acetamidonaphthalene is weakly mutagenic to Salmonella typhimurium TA98 with metabolic activation. 1-Acetamidonaphthalene can be used for the research of bacterial infection .

HY-N3549

Catalpin	Bacterial	Infection
Catalpin is an iridoid that can be isoalted from Catalpae Fructus.Catalpin shows mutagenic activity towards Salmonella typhimurium strain TA100 .

HY-134013

Piperitenone oxide	DNA/RNA Synthesis Endothelin Receptor	Cardiovascular Disease Cancer
Piperitenone oxide is an orally active monoterpene ketone. Piperitenone oxide can be isolated from the essential oils of plants belonging to Mentha x villosa and Ziziphora clinopodioides. Piperitenone oxide induces differentiation. Piperitenone oxide induces chromosome breakage damage, aneuploidy damage and DNA single-strand breaks. Piperitenone oxide reduces ET-1 levels. Piperitenone oxide exerts antihypertensive effects. Piperitenone oxide can be used in studies related to colon cancer .

HY-163292

Antibacterial agent 180	Bacterial Parasite	Infection
Antibacterial agent 180 (15g), an appropriate substrate for the type I nitro reductases (TcNTR I), is a promising antitrypanosomatid agent. Antibacterial agent 180 (15g) shows nonmutagenic potential against Salmonella typhimurium strains (TA98, TA100, and TA102) .

HY-W001189S

1,3-Dithiane-d2	Isotope-Labeled Compounds Bacterial	Infection
1,3-Dithiane-d2 is the deuterium labeled 1,3-Dithiane (HY-W001189). 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-W001189R

1,3-Dithiane (Standard)	Reference Standards Bacterial	Infection
1,3-Dithiane (Standard) is an analytical standard of 1,3-Dithiane (HY-W001189). This product is intended for research and analytical applications. 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-N17457

N-Demethyl-N-formyldehydronuciferine	Bacterial	Infection
N-Demethyl-N-formyldehydronuciferine is a dehydroaporphine alkaloid. N-Demethyl-N-formyldehydronuciferine induces mutations in Salmonella typhimurium TA98 and TA100 .

HY-N3616

trans-Coniferyl aldehyde	DNA/RNA Synthesis Endogenous Metabolite	Cancer
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID₅₀ value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1 .

HY-W250061

(-)-(1S,3S)-MTCA	Others	Cancer
(-)-(1S,3S)-MTCA can be isolated from Japanese soy sauce. (-)-(1S,3S)-MTCA induces revertants of Salmonella typhimurium TA100, after treatment with nitrite .

HY-24366

Quindoxin	Bacterial DNA/RNA Synthesis	Infection
Quindoxin is an antibacterial and growth promoter, commonly used in the livestock industry. Quindoxin exhibits clear dose-dependent mutagenic activity against Salmonella typhimurium TA98 and TA100 strains. Quindoxin can cause DNA damage and has potential genotoxicity and carcinogenic risks .

HY-W275553R

4-Decanol (Standard)	DNA Alkylator/Crosslinker Reference Standards	Infection
4-Decanol (Standard) is the analytical standard of 4-Decanol (HY-W275553). This product is intended for research and analytical applications. 4-Decanol is an antimutagenic compound, that can be isolated from mustard leaves. 4-Decanol inhibits mutagenic activities of Aflatoxin B1 (HY-N6615) and MNNG (HY-128612) in Salmonella typhimurium TA100 .

HY-182366

EED-IN-5	Histone Methyltransferase	Neurological Disease Inflammation/Immunology
EED-IN-5 is an orally active, EZH2-selective trisubstituted pyridine-based EED-H3K27me3 inhibitor and immunomodulator with anti-inflammatory activity. The IC₅₀ value of EED-IN-5 against EED is 28.21 nM. In mouse models, EED-IN-5 preferentially and persistently accumulates in lymph nodes after oral administration. By reducing the H3K27me3 level of dendritic cells and inhibiting their migration, EED-IN-5 decreases the infiltration of specific dendritic cells, macrophages and T cells into the spinal cord and brain. EED-IN-5 exhibits hERG inhibitory activity, shows negative results in the Mini-Ames test, and causes no obvious toxicity upon long-term high-dose administration. EED-IN-5 can be used for the research of multiple sclerosis .

HY-182365

EED-IN-4	Histone Demethylase	Neurological Disease Inflammation/Immunology
EED-IN-4 is an orally active, EZH2-selective immunomodulator and EED-H3K27me3 inhibitor (EED, IC₅₀=28.21 nM) with anti-inflammatory activity. In mouse models, EED-IN-4 preferentially and persistently accumulates in lymph nodes after oral administration. By reducing the H3K27me3 level of dendritic cells and inhibiting their migration, EED-IN-4 reduces the infiltration of immune cells into the central nervous system and effectively alleviates spinal cord inflammation. EED-IN-4 shows weak inhibitory activity against hERG channels and is non-mutagenic, with no obvious toxicity observed upon long-term oral administration. EED-IN-4 can be used for the research of multiple sclerosis .

HY-W115785

Zinc borate	Environmental Pollutants VEGFR RUNX	Metabolic Disease
Zinc borate is a bioactive inorganic substance with properties including osteogenic induction, pro-angiogenesis, antioxidation, antimutagenesis and cytotoxicity. In the field of bone tissue engineering, Zinc borate is often incorporated into chitosan scaffolds. By releasing zinc ions and borate ions, Zinc borate induces the differentiation of human dental pulp stem cells into osteoblasts, upregulates the expression of bone-related genes and promotes calcium deposition. Zinc borate also promotes angiogenesis by upregulating key factors such as vascular endothelial growth factor. Zinc borate exhibits antioxidant capacity to scavenge free radicals, and can specifically reduce mutagenicity under specific conditions. Zinc borate reduces the survival rate of mouse fibroblasts, but it can still be used in studies related to bone tissue engineering .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W275553

4-Decanol	Natural Products Capillipedium parviflorum (R. Br.) Stapf Gramineae Plants Source Classification	DNA Alkylator/Crosslinker
4-Decanol is an antimutagenic compound, that can be isolated from mustard leaves. 4-Decanol inhibits mutagenic activities of Aflatoxin B1 (HY-N6615) and MNNG (HY-128612) in Salmonella typhimurium TA100 .

HY-W001189

1,3-Dithiane	Infection Natural Products Animals Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Bacterial
1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-N5054

(R)-5,7-Dimethoxyflavanone	Flavonoids other families Classification of Application Fields Flavonones Plants Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-N3549

Catalpin	Iridoids Terpenoids Sorbus pohuashanensis (Hance) Hedl. Rosaceae Plants Source Classification	Bacterial
Catalpin is an iridoid that can be isoalted from Catalpae Fructus.Catalpin shows mutagenic activity towards Salmonella typhimurium strain TA100 .

HY-W001189R

1,3-Dithiane (Standard)	Structural Classification Natural Products Animals Endogenous metabolite Source Classification	Reference Standards Bacterial
1,3-Dithiane (Standard) is an analytical standard of 1,3-Dithiane (HY-W001189). This product is intended for research and analytical applications. 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

HY-N17457

N-Demethyl-N-formyldehydronuciferine	Structural Classification Alkaloids Other Alkaloids Plants Tinospora crispa (L.) Hook. f. et Thoms Menispermaceae Source Classification	Bacterial
N-Demethyl-N-formyldehydronuciferine is a dehydroaporphine alkaloid. N-Demethyl-N-formyldehydronuciferine induces mutations in Salmonella typhimurium TA98 and TA100 .

HY-N3616

trans-Coniferyl aldehyde	Monophenols Simple Phenylpropanols Phenols Myrtaceae Syzygium aromaticum (L.) Merr. & L.M.Perry Phenylpropanoids Plants Source Classification	DNA/RNA Synthesis Endogenous Metabolite
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID₅₀ value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1 .

HY-W250061

(-)-(1S,3S)-MTCA	Structural Classification Alkaloids Piperidine Alkaloids Marine natural products Other marine organisms Source Classification	Others
(-)-(1S,3S)-MTCA can be isolated from Japanese soy sauce. (-)-(1S,3S)-MTCA induces revertants of Salmonella typhimurium TA100, after treatment with nitrite .

HY-W275553R

4-Decanol (Standard)	Structural Classification Natural Products Capillipedium parviflorum (R. Br.) Stapf Gramineae Plants Source Classification	DNA Alkylator/Crosslinker Reference Standards
4-Decanol (Standard) is the analytical standard of 4-Decanol (HY-W275553). This product is intended for research and analytical applications. 4-Decanol is an antimutagenic compound, that can be isolated from mustard leaves. 4-Decanol inhibits mutagenic activities of Aflatoxin B1 (HY-N6615) and MNNG (HY-128612) in Salmonella typhimurium TA100 .

Cat. No.	Product Name	Chemical Structure

HY-W001189S

1,3-Dithiane-d2
1,3-Dithiane-d2 is the deuterium labeled 1,3-Dithiane (HY-W001189). 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against *S. typhimurium* TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon .

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TA100

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products