3 Results for "

TLK 199

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "TLK 199" in MCE Product Catalog:

  • Targets Recommended:
8
8 Publications Verification
Art. -Nr.: HY-13634A
CAS. Nr.: 168682-53-9
Reinheit:  99.71%
Synonyms: TER199free base; TLK199
Forschungsgebiete:  

Cancer

Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment .
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1
1 Cited Publications
Art. -Nr.: HY-13634B
CAS. Nr.: 152684-53-2
Reinheit:  99.89%
Synonyms: TER117
Forschungsgebiete:  

Inflammation/Immunology Cancer

TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.
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Art. -Nr.: HY-13634
CAS. Nr.: 286942-97-0
Synonyms: TER199; TLK199 hydrochloride
Forschungsgebiete:  

Cancer

Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment .
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