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Results for "

TPX2

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Recombinant Proteins

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125956
    Aurkin A

    		Aurora Kinase Apoptosis Cancer
    Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer [2].
    Aurkin A
  • HY-168022
    CAM2602
    1 Publications Verification

    		 Aurora Kinase Cancer
    CAM2602 is an orally active Aurora A-TPX2 protein−protein interaction inhibitor with a human Kd of 19 nM for Aurora A. CAM2602 increases the proportion of PH3 positive cells while reducing P-T288 Aurora A levels. CAM2602 arrests tumor xenograft growth in mice. CAM2602 can be used for the research of cancer, such as acute T cell leukemia .
    CAM2602
  • HY-122236
    UMK57

    		Mitosis Kinesin Microtubule/Tubulin Aurora Kinase Cancer
    UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors [2].
    UMK57
  • HY-RS14959
    TPX2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TPX2 Human Pre-designed siRNA Set A contains three designed siRNAs for TPX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TPX2 Human Pre-designed siRNA Set A
    TPX2 Human Pre-designed siRNA Set A
  • HY-RS19965
    Tpx2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tpx2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tpx2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tpx2 Mouse Pre-designed siRNA Set A
    Tpx2 Mouse Pre-designed siRNA Set A
  • HY-RS26468
    Tpx2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tpx2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tpx2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tpx2 Rat Pre-designed siRNA Set A
    Tpx2 Rat Pre-designed siRNA Set A
  • HY-158038
    AurkA allosteric-IN-1

    		Aurora Kinase Mitosis Cancer
    AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA .
    AurkA allosteric-IN-1
  • HY-183102
    ATC12

    		Aurora Kinase Apoptosis Cancer
    ATC12 is a Aurora-A kinase inhibitor. ATC12 binds to Aurora-A and competes with TPX2 for binding to disrupt the Aurora-A/TPX2 interaction. ATC12 inhibits cancer cell proliferation, induces apoptosis and cellular senescence. ATC12 can be used in the research of breast cancer .
    ATC12

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