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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Taurolithocholic acid
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Taurolithocholic acid" in MCE Product Catalog:
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Research Areas:
Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .
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6 Publications Verification
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1 Cited Publications
Cat. No.: HY-113308S1
CAS No.: 2410279-96-6
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1 Cited Publications
Cat. No.: HY-137255
CAS No.: 64936-83-0
Synonyms: 3-SulfoTaurolithocholic acid disodium
Cat. No.: HY-113308AR
CAS No.: 6042-32-6
Cat. No.: HY-113308AS1
CAS No.: 1265476-97-8
Cat. No.: HY-137255S
Synonyms: 3-SulfoTaurolithocholic acid-d4 disodium
Cat. No.: HY-N15890
CAS No.: 2707415-30-1
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Cat. No.: HY-113308S
CAS No.: 1265681-64-8
Cat. No.: HY-113308AS2
Cat. No.: HY-W746663
CAS No.: 66874-07-5
Synonyms: 12-Hydroxy Taurolithocholic acid sulfate disodium
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
