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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
TrxR2
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "TrxR2" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-D1250
CAS No.: 1859102-62-7
1
1 Cited Publications
Cat. No.: HY-150228
Purity: ≥95.0%
MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy .
Cat. No.: HY-182324
CAS No.: 3085154-16-8
Research Areas:
TrxR2-IN-1 is a thioredoxin reductase 2 (TrxR2) inhibitor with an IC50 value of 0.83 μM. TrxR2-IN-1 accumulates in mitochondria, impairs mitochondrial function and membrane potential, increases reactive oxygen species (ROS) levels, activates ASK1-mediated caspase-dependent apoptosis (apoptosis), induces G2/M cell cycle arrest, and inhibits cancer cell migration. TrxR2-IN-1 can be used in the research of hepatocellular carcinoma .
Cat. No.: HY-P85559
Synonyms: mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TrxR 2; TrxR2; TrxR2_HUMAN; TXNRD 2; Txnrd2.
Cat. No.: HY-149035
Research Areas:
PAA4 is a hypercoordinate carbon-centered tetranuclear gold (I) cluster prodrug . PAA4 releases active Au (I) ions upon triggering by GSH (HY-D0187), and this process is accelerated in the acidic microenvironment of bladder cancer cells with high GSH expression. PAA4 inhibits the activities of cytosolic TrxR1 and mitochondrial TrxR2, inducing ROS accumulation, lipid peroxidation, ferroptosis, loss of mitochondrial membrane potential and DNA damage. PAA4 can be used in bladder cancer-related research .
Cat. No.: HY-RS20613
Target:
Research Areas:
Txnrd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Txnrd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P80913
Synonyms: mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TrxR 2; TrxR2; TrxR2_HUMAN; TXNRD 2; Txnrd2.
Cat. No.: HY-RS15299
Target:
Research Areas:
TXNRD2 Human Pre-designed siRNA Set A contains three designed siRNAs for TXNRD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P80913A
Synonyms: mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TrxR 2; TrxR2; TrxR2_HUMAN; TXNRD 2; Txnrd2.
Cat. No.: HY-RS27121
Target:
Research Areas:
Txnrd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Txnrd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-183544
Research Areas:
Platinum (IV) Prodrug-1 is a Pt (IV) prodrug and selective TrxR1 inhibitor. Platinum (IV) Prodrug-1 induces ferroptosis (Ferroptosis) by depleting glutathione, accumulating intracellular lipid peroxides, and inactivating Glutathione peroxidase 4. Platinum (IV) Prodrug-1 triggers endoplasmic reticulum stress and immunogenic cell death via excessive accumulation of intracellular ROS. Platinum (IV) Prodrug-1 exhibits anticancer activity against both Cisplatin (HY-17394)-sensitive and Cisplatin-resistant triple-negative breast cancer cells. Platinum (IV) Prodrug-1 can be used for the research of triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
