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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Ucp2
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Ucp2" in MCE Product Catalog:
22
Category:
Neurological Disease Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids Gardenia jasminoides Ellis Disease Research Fields Inflammation/Immunology Rubiaceae Extract
Target:
2
2 Cited Publications
Target:
Forschungsgebiete:
TAK-418 is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC50 of 2.9 nM. TAK-418 irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders [2] .
Art. -Nr.: HY-P5534
CAS. Nr.: 524060-93-3
Synonyms: Ucp2
Target:
Forschungsgebiete:
Category:
Human Gut Microbiota Metabolites Iridoids Terpenoids Plants Gardenia jasminoides Ellis Endogenous metabolite Rubiaceae Extract
Target:
Art. -Nr.: HY-RS15411
Target:
Forschungsgebiete:
UCP2 Human Pre-designed siRNA Set A contains three designed siRNAs for UCP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS24369
Target:
Forschungsgebiete:
Ucp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ucp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS17900
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Forschungsgebiete:
Ucp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ucp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-101824
CAS. Nr.: 179068-64-5
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Forschungsgebiete:
NC-2100 is a PPAR activator. NC-2100 can effectively reduce the plasma glucose and triglyceride levels of obese KKAy mice. NC-2100 can induce UCP1 and UCP2 expression in mesenteric and subcutaneous WAT of mice. NC-2100 can be used in research related to type 2 diabetes .
Art. -Nr.: HY-189057
Forschungsgebiete:
Anethole trithione derivative-1 is a derivative of Anethole trithione (HY-B1223), and also a regulator of sulfide:quinone oxidoreductase (SQR) and uncoupling protein 2 (UCP2), with mitochondrial uncoupling-inducing activity and neuroprotective activity. Anethole trithione derivative-1 mediates mitochondrial uncoupling via SQR-dependent reverse electron transport of complex I, ROS-dependent UCP2 activation, and reduction of mitochondrial membrane potential. Anethole trithione derivative-1 reduces brain damage and improves function in mouse models of ischemic and hemorrhagic stroke. Anethole trithione derivative-1 can be used in stroke research .
Art. -Nr.: HY-138830B
CAS. Nr.: 1818252-52-6
Target:
Forschungsgebiete:
TAK-418 free base is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC50 of 2.9 nM. TAK-418 free base irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 free base restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 free base rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 free base can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders [2] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
