2. Search Result
Search Result
Results for "

VHL ligand-1

" in MedChemExpress (MCE) Product Catalog:

23

Inhibitors & Agonists

1

Click Chemistry

Targets Recommended:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-112078
    (S,R,S)-AHPC-Me

    VHL ligand 2; E3 ligase ligand 1A

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
    (S,R,S)-AHPC-Me
  • HY-42424
    (S,R,S)-AHPC-Me hydrochloride

    VHL ligand 2 hydrochloride; E3 ligase ligand 1

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
    (S,R,S)-AHPC-Me hydrochloride
  • HY-101763A
    (S,R,S)-AHPC monohydrochloride
    2 Publications Verification

    VH032-NH2 monohydrochloride; VHL ligand 1 monohydrochloride

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein .
    (S,R,S)-AHPC monohydrochloride
  • HY-47070
    VH 101, acid

    		Ligands for E3 Ligase Others
    VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .
    VH 101, acid
  • HY-125845
    (S,R,S)-AHPC
    2 Publications Verification

    VH032-NH2; VHL ligand 1

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells .
    (S,R,S)-AHPC
  • HY-119932
    PROTAC FAK degrader 1
    Maximum Cited Publications
    8 Publications Verification

    		 PROTACs FAK Akt Cancer
    PROTAC FAK degrader 1 (Compound PROTAC-3) is a selective and effective degrader of Fak PROTAC with a DC50 of 3.0 nM. PROTAC FAK degrader 1 reduces the ability of cancer cells to migrate and invade. PROTAC FAK degrader 1 can be used in the study of tumor. (Pink: Fak ligand (HY-44146); Black: Linker (HY-44141); Blue: VHL ligand 1 (HY-125845)) .
    PROTAC FAK degrader 1
  • HY-42424A
    (S,R,S)-AHPC-Me dihydrochloride

    VHL ligand 2 dihydrochloride; E3 ligase ligand 1 dihydrochloride

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein . (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
    (S,R,S)-AHPC-Me dihydrochloride
  • HY-163167
    VH 032 amide-alkylC5-azide

    		E3 Ligase Ligand-Linker Conjugates Others
    VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .
    VH 032 amide-alkylC5-azide
  • HY-136005
    VH032-C7-COOH

    		E3 Ligase Ligand-Linker Conjugates Others
    VH032-C7-COOH is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH032-C7-COOH contains an E3 ligase ligand and an alkyl linker with a terminal amine for conjugation of target protein ligands .
    VH032-C7-COOH
  • HY-110402
    (S,R,S)-AHPC TFA

    VH032-NH2 TFA; VHL ligand 1 TFA

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells .
    (S,R,S)-AHPC TFA
  • HY-157512
    SJF-0661

    		Ligands for E3 Ligase Cancer
    SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand with no targeted degradation ability and can be used as a control reagent for the VHL ubiquitin ligase ligand. SJF-0661 is a variant obtained by inverting the stereocenter of the key hydroxyproline group in the VHL ligand .
    SJF-0661
  • HY-W998246
    (R,R,S)-AHPC

    (R,R,S)-VH032-NH2; (R,R,S)-VHL ligand 1

    		 Ligands for E3 Ligase Cancer
    (R,R,S)-AHPC ((R,R,S)-VH032-NH2) is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (R,R,S)-AHPC can be linked to a target protein ligand via a linker to form a PROTACs.
    (R,R,S)-AHPC
  • HY-W128709
    SNAP-fusion protein ligand-1

    		Ligands for Target Protein for PROTAC Others
    SNAP-fusion protein ligand-1 (Compound 3) is a Ligand for Target Protein for PROTAC. SNAP-fusion protein ligand-1 can be used for synthesis of PROTAC VHL-SNAP2-5C (HY-175417) .
    SNAP-fusion protein ligand-1
  • HY-174858
    dASK1-VHL

    		PROTACs ASK1 p38 MAPK Metabolic Disease
    dASK1-VHL is an orally active PROTAC degrader targeting ASK1. dASK1-VHL can effectively bind VHL and promote the selective degradation of ASK1. dASK1-VHL effectively reduces ASK1 protein levels, inhibits the activation of p38 MAPK, and reduces liver lipid content. dASK1-VHL provides new ideas for the study of Metabolic dysfunction-associated steatohepatitis (MASH) (Pink: ASK1 ligand 1 (HY-174860); Blue: E3 ligand (S,R,S)-AHPC (HY-125845); Black: Linker, (S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH (HY-174861) .
    dASK1-VHL
  • HY-170859A
    AH081

    		PROTACs Casein Kinase Cancer
    AH081 (Compound 38) is a CK1δ/ε PROTAC degrader. AH081 is the negative control compound of AH078 (HY-170859). AH081 has inhibitory but no degradation activity for CK1δ/ε by using an inactive stereoisomer of the VHL ligand . Pink: CK1δ/ε ligand (HY-148251); Blue: VHL ligase ligand (HY-125845B); Black: linker
    AH081
  • HY-101763B
    (S,R,S)-AHPC dihydrochloride

    VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC (VH032-NH2) dihydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC dihydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells .
    (S,R,S)-AHPC dihydrochloride
  • HY-101763AR
    (S,R,S)-AHPC monohydrochloride (Standard)

    VH032-NH2 monohydrochloride (Standard); VHL ligand 1 monohydrochloride (Standard)

    		 Reference Standards Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC monohydrochloride (Standard) (VH032-NH2 monohydrochloride (Standard)) is the analytical standard of (S,R,S)-AHPC monohydrochloride (HY-101763A). This product is intended for research and analytical applications. (S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein .
    (S,R,S)-AHPC monohydrochloride (Standard)
  • HY-174860
    ASK1 ligand 1

    		Ligands for Target Protein for PROTAC ASK1 Cancer
    ASK1 ligand 1 is a binding ligand for ASK1 and can be used to synthesize PROTACs such as dASK1-VHL (HY-174858 )[1].
    ASK1 ligand 1
  • HY-161368
    BRD-SF2

    		PROTACs Epigenetic Reader Domain Cancer
    BRD-SF2 is a BRD4-targeted PROTAC degrader (DC50: 17.2 μM) (Blue: VHL ligand, black: linker, pink: BRD4 ligand) .
    BRD-SF2
  • HY-162450
    Antitumor agent-150

    		PROTACs MDM-2/p53 Apoptosis Cancer
    Antitumor agent-150 (V10), an anti-breast cancer agent, is a PROTAC-based MDM2 protein degrader (Red: Ganoderic acid A; Black: 4O-PEG linker; Blue: VHL ligand) .
    Antitumor agent-150
  • HY-141486
    (Rac)-PROTAC PARP/EGFR ligand 1

    		Target Protein Ligand-Linker Conjugates Cancer
    (Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP .
    (Rac)-PROTAC PARP/EGFR ligand 1
  • HY-163209
    VH 032 amide-PEG6-amine hydrochloride

    (S,R,S)-AHPC-PEG6-NH2 hydrochloride

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    VH 032 amide-PEG6-amine hydrochloride (Step 4) is a functionalized von-Hippel-Lindau protein-ligand (VHL) for PROTAC development, consisting of an E3 ligand and a PEG6 ligand. Terminal amines can be coupled to target protein ligands .
    VH 032 amide-PEG6-amine hydrochloride
  • HY-162834
    PROTAC SMARCA2/4-degrader-27

    		PROTACs Epigenetic Reader Domain Cancer
    PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of SMARCA2 and SMARCA4. (Blue: CRL2 VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA-BD ligand 1 for PROTAC (HY-44012)) .
    PROTAC SMARCA2/4-degrader-27

온라인 문의

Your information is safe with us. * Required Fields.

호칭

  

Country or Region *

고객명 *

 

회사명 *

Department *

     

메일주소 *

 

상품명 *

Cat. No.

  

Requested quantity *

전화번호 *

     

비고

온라인 문의

Inquiry Information

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent: