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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

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Vitamin D3 derivative

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By Targets:	Drug Derivative (1) VD/VDR (10) Aryl Hydrocarbon Receptor (1) Calcium Channel (1) Cytochrome P450 (1) Drug Metabolite (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) NF-κB (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Metabolic Disease (9) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Derivative VD/VDR VKOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112023

Lumisterol 3 (purity>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Endogenous Metabolite	Metabolic Disease
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D .

HY-N0682S

Pyridoxine-d3 hydrochloride Pyridoxol-D3 hydrochloride; Vitamin B6-D3 hydrochloride	Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine-d₃ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-15830

25,26-Dihydroxyvitamin D3 25,26-Dihydroxycholecalciferol	VD/VDR Drug Metabolite Drug Derivative Calcium Channel	Metabolic Disease
25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia .

HY-154825

20-Hydroxyvitamin D3 20(OH)D3; 20S-HydroxyVitamin D3	VD/VDR Aryl Hydrocarbon Receptor NF-κB Cytochrome P450	Inflammation/Immunology Cancer
20-Hydroxyvitamin D3 (20(OH)D3), a product of vitamin D3 hydroxylation, is a noncalcemic immunomodulator. 20-Hydroxyvitamin D3 binds to vitamin D receptor (VDR), activates VDR and aryl hydrocarbon receptor (AhR) signaling, stimulates CYP24A1 expression, and drives VDR nuclear translocation. 20-Hydroxyvitamin D3 inhibits NF-κB activity via IκBα upregulation. 20-Hydroxyvitamin D3 acts as a substrate for CYP27B1 and rat CYP24A1, undergoing hydroxylation to form dihydroxy-derivatives. 20-Hydroxyvitamin D3 inhibits cell proliferation, colony formation, migration, and tumor growth, and induces cell differentiation in cancer cells. 20-Hydroxyvitamin D3 can be used for the research of inflammatory and autoimmune diseases, melanoma, breast carcinomas, and hepatocarcinoma .

HY-134493

Butyrate-Vitamin D3 Butyrate-Cholecalciferol; Butyrate-Colecalciferol	VD/VDR	Metabolic Disease Inflammation/Immunology Cancer
Butyrate-Vitamin D3 (Butyrate-Cholecalciferol) is a derivative of vitamin D3 in which a hydroxyl group in the vitamin D3 molecule is replaced by a butyric acid group. Butyrate-Vitamin D3 affects gene expression and cell function and has certain anti-inflammatory effects. Butyrate-Vitamin D3 can be used in the study of immune regulation, metabolic diseases and cancer .

HY-76802

Calcitriol Derivatives	VD/VDR	Metabolic Disease
Calcitriol Derivatives is a vitamin D3 analog.

HY-15254

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 1 Publications Verification 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether	VD/VDR	Metabolic Disease
3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.

HY-U00424

Chol-5-en-24-al-3β-ol Vitamin D3 derivative	VD/VDR	Metabolic Disease
Chol-5-en-24-al-3β-ol is a steroid compound (Vitamin D3 derivative) extracted from patent US 4354972 A, Compound IX.

HY-W754025

Pre-vitamin D3 decanoate	VD/VDR	Others
Pre-vitamin D3 decanoate is a derivative of vitamin D3 that can be converted into the active form of vitamin D in the body. Pre-vitamin D3 decanoate is first converted to 25-hydroxyvitamin D3 in the liver and then further converted to 1,25-dihydroxyvitamin D3 in the kidneys. During preparation, vitamin D3 may react with the triglycerides in the formulation to form ester compounds, and this esterification affects the stability and bioavailability of vitamin D3. Pre-vitamin D3 decanoate can be used in the study of certain diseases associated with vitamin D, such as osteoporosis, autoimmune diseases, and certain cancers .

HY-15267B

(24S)-MC 976	VD/VDR	Metabolic Disease
(24S)-MC 976 is a Vitamin D3 derivative.

HY-15267

MC 976	VD/VDR	Metabolic Disease
MC 976 is a Vitamin D3 derivative.

HY-15267A

(24R)-MC 976	VD/VDR	Metabolic Disease
(24R)-MC 976 is a Vitamin D3 derivative.

HY-W721166

Riboflavin phosphate-d3 sodium Riboflavine phosphate-D3 sodium; Riboflavin 5'-phosphate-D3 sodium; Riboflavine 5'-phosphate-D3 sodium	Isotope-Labeled Compounds Endogenous Metabolite	Others
Riboflavin phosphate-d₃ sodium (Riboflavine phosphate-d₃ sodium; Riboflavin 5'-phosphate-d₃ sodium; Riboflavine 5'-phosphate-d₃ sodium) is the deuterium labeled Riboflavin phosphate sodium (HY-B0964). Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium is a very effective NAD+-recycling agent .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-112023

Lumisterol 3 (purity>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D .

HY-15830

25,26-Dihydroxyvitamin D3 25,26-Dihydroxycholecalciferol	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	VD/VDR Drug Metabolite Drug Derivative Calcium Channel
25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia .

HY-134493

Butyrate-Vitamin D3 Butyrate-Cholecalciferol; Butyrate-Colecalciferol	Natural Products Endogenous metabolite Source Classification	VD/VDR
Butyrate-Vitamin D3 (Butyrate-Cholecalciferol) is a derivative of vitamin D3 in which a hydroxyl group in the vitamin D3 molecule is replaced by a butyric acid group. Butyrate-Vitamin D3 affects gene expression and cell function and has certain anti-inflammatory effects. Butyrate-Vitamin D3 can be used in the study of immune regulation, metabolic diseases and cancer .

Cat. No.	Product Name	Chemical Structure

HY-N0682S

Pyridoxine-d3 hydrochloride
Pyridoxine-d₃ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-W721166

Riboflavin phosphate-d3 sodium
Riboflavin phosphate-d₃ sodium (Riboflavine phosphate-d₃ sodium; Riboflavin 5'-phosphate-d₃ sodium; Riboflavine 5'-phosphate-d₃ sodium) is the deuterium labeled Riboflavin phosphate sodium (HY-B0964). Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium is a very effective NAD+-recycling agent .

Riboflavin phosphate-d3 sodium

Riboflavin phosphate-d₃ sodium (Riboflavine phosphate-d₃ sodium; Riboflavin 5'-phosphate-d₃ sodium; Riboflavine 5'-phosphate-d₃ sodium) is the deuterium labeled Riboflavin phosphate sodium (HY-B0964). Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium is a very effective NAD+-recycling agent .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Vitamin D3 derivative

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products