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Pathways Recommended:	Stem Cell/Wnt

Results for "

Wnt/β-catenin-IN-4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Wnt (4) Androgen Receptor (1) β-catenin (2)
By Research Areas:	Cancer (2) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Targets Recommended: Wnt

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151520

**Wnt/β-catenin agonist 4**	Wnt	Cancer
Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of *Wnt* that activates *Wnt/β-catenin* signal transmission .

HY-133179

*Wnt/β-catenin-IN-4*	Wnt	Metabolic Disease
Wnt/β-catenin-IN-4 (compound YW1159) is a potent *Wnt/β-catenin* inhibitor .

HY-181560

SLD1121	Wnt β-catenin	Metabolic Disease
SLD1121 is an agonist of the *Wnt/β-catenin* signaling pathway that enhances *Wnt* signaling by targeting LRP6 (K_d: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to *β-catenin, TCF4* or LEF1 in the nucleus, thereby inducing the expression of *Wnt*-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research .

HY-P11660

*β-catenin-IN-10*	β-catenin Wnt Androgen Receptor	Cancer
β-catenin-IN-10 is a *β-catenin:TCF4* interaction inhibitor with an IC₅₀ of 5.44 μM. β-catenin-IN-10 inhibits the *Wnt* and AR signaling pathways with IC₅₀ values of 0.105 μM and 1.02 μM, respectively. β-catenin-IN-10 suppresses the proliferation of castration-resistant prostate cancer cells. β-catenin-IN-10 is applicable to research related to prostate cancer .

Cat. No.	Product Name	Target	Research Area

HY-P11660

*β-catenin-IN-10*	β-catenin Wnt Androgen Receptor	Cancer
β-catenin-IN-10 is a *β-catenin:TCF4* interaction inhibitor with an IC₅₀ of 5.44 μM. β-catenin-IN-10 inhibits the *Wnt* and AR signaling pathways with IC₅₀ values of 0.105 μM and 1.02 μM, respectively. β-catenin-IN-10 suppresses the proliferation of castration-resistant prostate cancer cells. β-catenin-IN-10 is applicable to research related to prostate cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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