Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
actin filament
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "actin filament" in MCE Product Catalog:
47
Target:
29
29 Cited Publications
Cat. No.: HY-16926
CAS No.: 442633-00-3
Target:
CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation .
9
9 Cited Publications
Cat. No.: HY-P0027
CAS No.: 102396-24-7
Category:
Antifungal Marine natural products Disease Research Other Antibiotics Infection Monophenols Animals Antibiotics Cyclopeptides Phenols Sponge Anticancer Disease Research Fields
Target:
8
NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response .
Cat. No.: HY-P2031
CAS No.: 26645-35-2
Target:
Target:
Cat. No.: HY-N6744
CAS No.: 50335-03-0
Cat. No.: HY-N6772
CAS No.: 36011-19-5
Target:
Target:
Research Areas:
TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion .
Cat. No.: HY-D1346
CAS No.: 1877282-17-1
Cat. No.: HY-175261
Target:
Research Areas:
DHI1 is an anti-leukemia agent with high selectivity for Jurkat (IC50 = 21.83 μM) and HL-60 (IC50 = 19.14 μM) leukemia cells and has low toxicity to non-cancerous cells. DHI1 can induce G2/M phase cell arrest in Jurkat and HL-60 leukemia cells, as well as S phase arrest in HL-60 cells, and has significant effects on cell cycle signaling molecules Wee1, cyclin B1, cdc2 on Tyr15, and Chk1. DHI1 inhibits the migration and invasion of Jurkat and HL-60 cells by disrupting cytoskeletal actin filaments. DHI1 can be used to study hematological malignancies .
Cat. No.: HY-182487
CAS No.: 51053-39-5
Target:
Research Areas:
Deoxaphomin is a cytochalasin. Deoxaphomin inhibits Actin filament elongation and reduces the viscosity of polymerized actin filaments. Deoxaphomin induces rounding of fibroblasts, contraction of actin cables, formation of actin-containing hairy structures, and formation of actin-containing cytoplasmic rodlets in fibroblasts. Deoxaphomin inhibits membrane ruffling in fibroblasts and capping in lymphocytes .
Cat. No.: HY-E70841
Target:
Research Areas:
LIM kinase 2 (LIMK2) is a serine/threonine and tyrosine kinases. LIMK2 plays a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an actin depolymerising factor. LIMK2 Recombinant Human Active Protein Kinase is a recombinant LIMK2 protein that can be used to study LIMK2-related functions .
Cat. No.: HY-187686
CAS No.: 2606843-12-1
Target:
Research Areas:
UA49 is a plasma membrane voltage-dependent potassium channel inhibitor. UA49 inhibits the phosphorylation of plasma membrane H +-ATPase, reduces potassium ion levels in guard cells, increases calcium ion concentrations in the cytoplasm and endoplasmic reticulum, induces actin filament bundling, and triggers SLAC1-dependent stomatal closure through a pathway distinct from that of ABA. UA49 can be used in studies related to plant drought stress .
Cat. No.: HY-182478
CAS No.: 124711-23-5
Target:
Research Areas:
MDL-27048, a tubulin inhibitor, binds competitively, reversibly to the Colchicine (HY-16569)-binding site on tubulin heterodimers. MDL-27048 inhibits microtubule assembly, induces slow depolymerization of preassembled microtubules, disrupts microtubule polymerization-depolymerization dynamics, and disrupts cytoplasmic microtubule networks. MDL-27048 exerts growth inhibitory effects on human cancer cells, induces mitotic arrest, and does not disrupt actin filaments at microtubule-depolymerizing concentrations. MDL-27048 can be used for the research of malignant tumors .
Target:
Cat. No.: HY-P810428
Synonyms: actin capping protein GCAP39, actin regulatory protein CAP G, actin regulatory protein CAP-G, AFCP, Capg, CAPG_HUMAN, Capping actin protein gelsolin like, Capping protein (actin filament) gelsolin like, Capping protein gelsolin like, Epididymis secretory protein Li 66
Cat. No.: HY-P75601
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CAPG; actin Regulatory Protein CAP-G; Prev. AFCP; actin-Regulatory Protein CAP-G; MCP; Gelsolin-Like Capping Protein; Macrophage-Capping Protein; Macrophage Capping Protein; Capping Protein (actin filament), Gelsolin-Like; HEL-S-66; Capping actin Protein,
Species:
Human
Source:
E. coli
Cat. No.: HY-E70632
Target:
Research Areas:
PIP5K1B participates in the biosynthesis of PI(4,5)P2. PIP5K1B is at the crossroad of different signaling pathways, mediating RAC1-dependent reorganization of actin filaments and contributing to the activation of phospholipase D2. PIP5K1B Recombinant Human Active Lipid Kinase can be used for the study of Friedreich’s ataxia (FRDA) .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
