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adenosine A1/A2A receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (53) Apoptosis (17) Autophagy (15) Calcium Channel (2) Drug Intermediate (1) Endogenous Metabolite (21) Environmental Pollutants (1) ERK (1) Isotope-Labeled Compounds (14) JNK (1) MMP (1) Nucleoside Antimetabolite/Analog (15) PI3K (2) Reference Standards (11) Xanthine Oxidase (1)
By Research Areas:	Cancer (35) Cardiovascular Disease (12) Inflammation/Immunology (24) Metabolic Disease (16) Neurological Disease (21)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Adenosine Kinase Adenosine Deaminase Adenosine Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0228

Adenosine 15+ Cited Publications Adenine riboside; D-adenosine	Environmental Pollutants Autophagy Nucleoside Antimetabolite/Analog Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Adenosine (Adenine riboside), a ubiquitous and BBB-permeable endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-N0092

Inosine 15+ Cited Publications	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-19533

SCH 58261 15+ Cited Publications	Adenosine Receptor	Cancer
SCH 58261 is a potent, selective and competitive antagonist of **adenosine A2A receptor with an IC₅₀** of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively .

HY-12365

Namodenoson 3 Publications Verification CF-102; 2-Cl-IB-MECA	Adenosine Receptor	Cancer
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .

HY-103171

BAY 60-6583 5+ Cited Publications	Adenosine Receptor	Cardiovascular Disease Inflammation/Immunology
BAY 60-6583 is a potent and high-affinity agonist of adenosine A_2B receptor (EC₅₀=3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with K_i values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model .

HY-100678

CGS 15943	Adenosine Receptor PI3K	Inflammation/Immunology Cancer
CGS 15943 is an orally bioavailable non-xanthine **Adenosine Receptor antagonist. Its K_i** for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

HY-103166

PSB-603 3 Publications Verification	Adenosine Receptor	Inflammation/Immunology
PSB-603 is a potent and highly selective A_2B adenosine receptor antagonist exhibiting a K_i value of 0.553 nM and virtually no affinity for the human and rat A₁ and A_2A and the human A₃ receptors up to a concentration of 10 μM .

HY-121119

MRS 1523 5 Publications Verification	Adenosine Receptor Calcium Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
MRS 1523 is a potent and selective **adenosine A₃ receptor antagonist with K_i values of 18.9 nM and 113 nM for human** and rat A₃ receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A₁ and A_2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons .

HY-103181

N6-Cyclopentyladenosine CPA; UK-80882	Adenosine Receptor Apoptosis	Cardiovascular Disease Neurological Disease Cancer
N6-Cyclopentyladenosine (CPA) is a selective **Adenosine A₁ receptor agonist, with K_i** values of 2.3 nM, 790 nM and 43 nM for human A₁, A_2A and A₃ receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures .

HY-N0092S2

Inosine-13C5 2 Publications Verification	Isotope-Labeled Compounds Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Inosine- ¹³C₅ is the ¹³C₅ labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-B0228S1

Adenosine-13C5 Adenine riboside-¹³C₅; D-adenosine-¹³C₅	Apoptosis Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
Adenosine- ¹³C₅ is the ¹³C labeled Adenosine . Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0228S11

Adenosine-15N5 Adenine riboside-¹⁵N₅; D-adenosine-¹⁵N₅	Isotope-Labeled Compounds	Cancer
Adenosine- ¹⁵N₅ (Adenine riboside- ¹⁵N₅; D-Adenosine- ¹⁵N₅) is the ¹⁵N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-10857

Vipadenant 1 Publications Verification BIIB-014; CEB-4520	Adenosine Receptor	Neurological Disease
Vipadenant (BIIB-014; CEB-4520) is an **adenosine receptor antagonist, with K_i*s of 1.3 nM and 68 nM for A_2A* and A₁, respectively.

HY-14858

Derenofylline 2 Publications Verification SLV 320	Adenosine Receptor	Cardiovascular Disease
Derenofylline (SLV 320) is a potent, selective and orally active **adenosine A₁ receptor antagonist, with K_i** values of 1 nM, 200 nM and 398 nM for human A₁, A₃ and A_2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats .

HY-B0228R

Adenosine (Standard) Adenine riboside (Standard); D-adenosine (Standard)	Reference Standards Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite	Metabolic Disease Cancer
Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0228S13

Adenosine-13C10 Adenine riboside-¹³C₁₀; D-adenosine-¹³C₁₀	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Endogenous Metabolite Autophagy Apoptosis	Metabolic Disease Cancer
Adenosine- ¹³C₁₀ (Adenine riboside- ¹³C₁₀; D-Adenosine- ¹³C₁₀) is ¹³C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-B0228S9

Adenosine-13C10,15N5	Isotope-Labeled Compounds Apoptosis Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Metabolic Disease Cancer
Adenosine- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled Adenosine (HY-B0228) . Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-102024

A2A receptor antagonist 1 CPI-444 analog	Adenosine Receptor	Neurological Disease Cancer
A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both **adenosine A_2A receptor** and A₁ receptor with K_i values of 4 and 264 nM, respectively .

HY-B0228S6

Adenosine-d2 Adenine riboside-d₂; D-adenosine-d₂	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-d₂ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio

HY-103186

MRS-1706 1 Publications Verification	Adenosine Receptor	Inflammation/Immunology
MRS-1706 is a potent and selective **adenosine A_2B receptor inverse agonist. MRS-1706 has K_i** values of 1.39, 112, 157, and 230 nM for human A_2B, A_2A, A₁ and A₃ receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction .

HY-119413

9-Ethyladenine	Adenosine Receptor	Neurological Disease
9-Ethyladenine is a precursor of competitive antagonists of **adenosine receptors** (A₁, A₂, A₃), with no significant inhibitory effect on adenine phosphoribosyltransferase (APRT). 9-Ethyladenine derivatives have high affinity and selectivity for A₁ (K_i=27 nM), A₂A (K_i=46 nM), and A₃ (K_i=86 nM) receptors. 9-Ethyladenine does not inhibit brain APRT activity, can be used in the study of adenosine receptor-related diseases (such as nervous system diseases) models .

HY-B0228S4

Adenosine-1′-13C Adenine riboside-1′-¹³C; D-adenosine-1′-¹³C	Isotope-Labeled Compounds Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-1′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-148088

M1069 1 Publications Verification	Adenosine Receptor	Cancer
M1069 is a selective and orall active, dual A_2A/A_2B adenosine receptor antagonist with a selectivity of >100 fold against the A₁ and A₃ receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .

HY-B0228S

Adenosine-d1 Adenine riboside-d₁; D-adenosine-d	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite	Metabolic Disease Cancer
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-N0092R

Inosine (Standard)	Reference Standards Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A_2AR . Inosine dose-dependently induces hA_2AR-mediated ERK1/2 phosphorylation . Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes . In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .

HY-W004425

DMPX 3,7-Dimethyl-1-propargylxanthine	Adenosine Receptor	Neurological Disease
DMPX (3,7-Dimethyl-1-propargylxanthine) is a selective A_2A adenosine receptor (A_2A AR) antagonist that crosses the blood-brain barrier, with a K_i of 11 μM for rat A₂ adenosine receptor and a K_i of 45 μM for rat A₁ adenosine receptor. By blocking A2A receptors in specific brain regions, DMPX protects dopaminergic and GABAergic neurons from mitochondrial dysfunction. DMPX is applicable to research related to depression, Parkinson's disease and Huntington's disease .

HY-B0228S5

Adenosine-13C Adenine riboside-¹³C; D-adenosine-¹³C	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,

HY-103170

LUF5834	Adenosine Receptor	Others
LUF5834 is a selective A_2B adenosine receptor (A2BR) partial agonist (EC₅₀ = 12 nM). LUF5834 is also a partial *A₁/A_2A* adenosine receptor agonist (lacking selectivity) with K_i values of 2.6 and 28 nM, respectively .

HY-111767

BAY-545	Adenosine Receptor	Inflammation/Immunology
BAY-545 is a potent and selective A_2B adenosine receptor antagonist, with an IC₅₀ of 59 nM. BAY-545 also exhibits IC₅₀s of 66, 400, 280 nM for human, mouse, rat A_2B adenosine receptor in cells, respectively, and a K_i of 97 nM for human A_2B adenosine receptor, with more selectivity over A₁, A_2A, and A₃ adenosine receptor .

HY-136233A

PSB 0777 ammonium hydrate	Adenosine Receptor	Inflammation/Immunology
PSB 0777 ammonium hydrate is a potent and selective adenosine *A_2A* receptor full agonist with K_i values of 44.4 nM, 360 nM for rat and human A_2A receptors, respectively. PSB 0777 ammonium hydrate has K_i values of ≥10000 nM, 541 nM for rat and human A₁ receptors, respectively. PSB 0777 ammonium hydrate shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium hydrate has the potential for inflammatory bowel disease (IBS) research research .

HY-N0092S

Inosine-2,8-d2	Isotope-Labeled Compounds Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors .

HY-147908

Adenosine receptor inhibitor 2	Xanthine Oxidase Adenosine Receptor	Inflammation/Immunology
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A₁/A_2A ARs with higher affinity for the A₁- than the A_2AAR. Adenosine receptor inhibitor 2 has K_i values of 52.2 nM for the A₁AR and 167 nM for the A_2AAR .

HY-B0228S12

Adenosine-d13 Adenine riboside-d₁₃; D-adenosine-d₁₃	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Endogenous Metabolite Autophagy Apoptosis	Metabolic Disease Cancer
Adenosine-d₁₃ (Adenine riboside-d₁₃; D-Adenosine-d₁₃) is deuterium labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-148076

A2A receptor antagonist 3	Adenosine Receptor	Cancer
A2A receptor antagonist 3 (Example 92) is an **adenosine A2a receptor antagonist with a K_i** of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with K_is of 37, 107 and 1467 nM, respectively .

HY-14873

Tonapofylline BG 9928	Adenosine Receptor	Cardiovascular Disease Metabolic Disease
Tonapofylline (BG 9928) is an orally active and selective **adenosine A₁ receptor antagonist with a K_i** of 7.4 nM for human adenosine A₁ receptor (hA₁), which displays 915-fold selectivity versus human adenosine A_2A receptor and 12-fold selectivity versus human adenosine A_2B receptor and is used in development for the treatment of heart failure .

HY-W088152

8-Bromotheophylline	Drug Intermediate	Others
8-Bromotheophylline can be used for the synthesis of the Oxazolo[2,3-f]purinediones, which are evaluated for their affinity at adenosine A₁ and A_2A receptors .

HY-B0228S8

Adenosine-d1-2 Adenine riboside-d₁-2; D-adenosine-d-2	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-120652

A3AR antagonist 3	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 3 (compound 21) is a selective *A3 adenosine* receptor (A3AR) antagonist with a K_i** of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors .

HY-B0228S14

Adenosine-d9 Adenine riboside-d₉; D-adenosine-d₉	Isotope-Labeled Compounds	Others
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio .

HY-B0228S2

Adenosine-2′-13C Adenine riboside-2′-¹³C; D-adenosine-2′-¹³C	Isotope-Labeled Compounds Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-2′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-N0092S1

Inosine-13C	Adenosine Receptor Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Inosine- ¹³C is the ¹³C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-136233

PSB 0777 ammonium	Adenosine Receptor	Inflammation/Immunology
PSB 0777 ammonium is a potent and selective adenosine *A_2A* receptor full agonist with K_i values of 44.4 nM, 360 nM for rat and human A_2A receptors, respectively. PSB 0777 ammonium has K_i values of ≥10000 nM, 541 nM for rat and human A₁ receptors, respectively. PSB 0777 ammonium shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium has the potential for inflammatory bowel disease (IBS) research research .

HY-103187

HEMADO	Adenosine Receptor	Inflammation/Immunology Cancer
HEMADO is a potent and selective **adenosine A₃ receptor agonist with a K_i** of 1.1 nM at the human A₃ subtype . HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-179248

Adenosine receptor antagonist 7	Adenosine Receptor ERK JNK MMP	Cancer
Adenosine receptor antagonist 7 is an orally active triple *A1/A2A/A2B* adenosine receptor antagonist with K_i values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC₅₀ = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer .

HY-112840

ST3932	Adenosine Receptor	Neurological Disease
ST3932 is a metabolite of ST1535, acts as an antagonist of **adenosine A_2A receptor, with K_i*s of 8 nM and 33 nM for A_2A* and A₁ receptors, respectively.

HY-U00341

ST4206	Adenosine Receptor	Neurological Disease
ST4206 is a potent and orally active **adenosine A2A receptor antagonist, with K_i*s of 12 nM and 197 nM for adenosine* A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research .

HY-A0168S

Regadenoson-d3 CVT-3146-d₃	Isotope-Labeled Compounds Adenosine Receptor	Cardiovascular Disease Cancer
Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents .

HY-19310

AMP-579	Adenosine Receptor	Cardiovascular Disease Metabolic Disease
AMP-579 is an **adenosine receptor** agonist that primarily targets adenosine A1 and *A2_A* receptors (with K_i values of 1.7 and 4.5 nM for the A1 receptor in rat brain and adipocytes, and a K_i value of 56 nM for the *A2_A* receptor in rat brain). AMP-579 inhibits lipolysis, restores insulin-dependent glucose transport, and reduces heart rate through the activation of A1 receptors, while it induces vasodilation, particularly in coronary arteries, through the activation of *A2_A* receptors (with an IC₅₀ of 0.3 μM in porcine coronary arterial rings). AMP 579 shows potential for application in cardioprotection and the treatment of acute myocardial infarction .

HY-B0228S7

Adenosine-d1-1 Adenine riboside-d₁-1; D-adenosine-d-1	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-d-1 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S3

Adenosine-3′-13C Adenine riboside-3′-¹³C; D-adenosine-3′-¹³C	Isotope-Labeled Compounds Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-3′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0228

Adenosine 15+ Cited Publications Adenine riboside; D-adenosine	Structural Classification Natural Products Microorganisms Classification of Application Fields Marine natural products Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Autophagy Nucleoside Antimetabolite/Analog Endogenous Metabolite Apoptosis
Adenosine (Adenine riboside), a ubiquitous and BBB-permeable endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-N0092

Inosine 15+ Cited Publications	Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Adenosine Receptor Endogenous Metabolite
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-B0228R

Adenosine (Standard) Adenine riboside (Standard); D-adenosine (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite
Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-119413

9-Ethyladenine	Natural Products Microorganisms Neurological Disease Classification of Application Fields Disease Research Fields Source Classification	Adenosine Receptor
9-Ethyladenine is a precursor of competitive antagonists of **adenosine receptors** (A₁, A₂, A₃), with no significant inhibitory effect on adenine phosphoribosyltransferase (APRT). 9-Ethyladenine derivatives have high affinity and selectivity for A₁ (K_i=27 nM), A₂A (K_i=46 nM), and A₃ (K_i=86 nM) receptors. 9-Ethyladenine does not inhibit brain APRT activity, can be used in the study of adenosine receptor-related diseases (such as nervous system diseases) models .

HY-N0092R

Inosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Adenosine Receptor Endogenous Metabolite
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A_2AR . Inosine dose-dependently induces hA_2AR-mediated ERK1/2 phosphorylation . Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes . In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .

Cat. No.	Product Name	Chemical Structure

HY-N0092S2

Inosine-13C5 2 Publications Verification
Inosine- ¹³C₅ is the ¹³C₅ labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-B0228S1

Adenosine-13C5
Adenosine- ¹³C₅ is the ¹³C labeled Adenosine . Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0228S11

Adenosine-15N5

Adenosine- ¹⁵N₅ (Adenine riboside- ¹⁵N₅; D-Adenosine- ¹⁵N₅) is the ¹⁵N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0228S13

Adenosine-13C10

Adenosine- ¹³C₁₀ (Adenine riboside- ¹³C₁₀; D-Adenosine- ¹³C₁₀) is ¹³C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-B0228S9

Adenosine-13C10,15N5

Adenosine- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled Adenosine (HY-B0228) . Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0228S6

Adenosine-d2
Adenosine-d₂ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio

HY-B0228S4

Adenosine-1′-13C
Adenosine-1′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S

Adenosine-d1
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0228S5

Adenosine-13C
Adenosine- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,

HY-N0092S

Inosine-2,8-d2
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors .

HY-B0228S12

Adenosine-d13

Adenosine-d₁₃ (Adenine riboside-d₁₃; D-Adenosine-d₁₃) is deuterium labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-B0228S8

Adenosine-d1-2
Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S14

Adenosine-d9
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio .

HY-B0228S2

Adenosine-2′-13C
Adenosine-2′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-N0092S1

Inosine-13C
Inosine- ¹³C is the ¹³C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-A0168S

Regadenoson-d3

Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents .

HY-B0228S7

Adenosine-d1-1
Adenosine-d-1 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S3

Adenosine-3′-13C
Adenosine-3′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-W779021

Adenosine-15N
Adenosine- ¹⁵N (Adenine riboside- ¹⁵N) is ¹⁵N labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

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