1. GPCR/G Protein
  2. Adenosine Receptor

Vipadenant (Synonyms: BIIB-014; CEB-4520)

Cat. No.: HY-10857 Purity: 98.02%
Handling Instructions

Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.

For research use only. We do not sell to patients.

Vipadenant Chemical Structure

Vipadenant Chemical Structure

CAS No. : 442908-10-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.

IC50 & Target

Ki: 1.3 nM (A2A), 68 nM (A1)[1], 1005 nM (A3)[2]

In Vivo

Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen[1]. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (96.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1120 mL 15.5598 mL 31.1197 mL
5 mM 0.6224 mL 3.1120 mL 6.2239 mL
10 mM 0.3112 mL 1.5560 mL 3.1120 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

321.34

Formula

C₁₆H₁₅N₇O

CAS No.

442908-10-3

SMILES

NC1=NC2=C(N=NN2CC3=CC=C(N)C(C)=C3)C(C4=CC=CO4)=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Vipadenant
Cat. No.:
HY-10857
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Vipadenant

Cat. No.: HY-10857