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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
aldose reductase (AR)
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "aldose reductase (AR)" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-50289
CAS No.: 68367-52-2
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Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
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Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications .
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Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .
Category:
Flavonols other families Flavonoids Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
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Cat. No.: HY-120208
CAS No.: 1959605-73-2
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MK204 is an aldose reductase (AR) inhibitor that can be used in diabetes research .
Cat. No.: HY-122963
CAS No.: 189308-09-6
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Cat. No.: HY-162325
CAS No.: 3009908-95-3
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WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis .
Cat. No.: HY-106915
CAS No.: 143162-65-6
Synonyms: SPR 210
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SG-210 (SPR 210) is an orally active and selective aldose reductase (AR) inhibitor. SG-210 has IC50 values of 9.5 nM and 10 nM for AR from porcine lens and human placenta, respectively. SG-210 can inhibit sorbitol accumulation and ameliorate diabetic neuropathy and retinopathy in Streptozotocin (HY-13753)-induced diabetic rats. SG-210 can be used in the research of diseases such as diabetes-related complications .
Cat. No.: HY-N6883
CAS No.: 76015-42-4
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other families Flavonoids Flavones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
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Cat. No.: HY-115940
CAS No.: 1687735-82-5
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Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR). Aldose reductase-IN-2 has antioxidation capacity. Aldose reductase-IN-2 is a promising anti-diabetic complications agent .
Cat. No.: HY-147875
CAS No.: 2470019-41-9
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Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC50 of 3.164 μM and a Ki of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells .
Cat. No.: HY-115977
CAS No.: 1390616-76-8
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Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC50 of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis .
Cat. No.: HY-N7962
CAS No.: 40661-45-8
Category:
Phyla nodiflora (L.) E. L. Greene Quinones Verbenaceae Benzene Quinones Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-116508
CAS No.: 1462383-00-1
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MK 319 is a selective aldose reductase (AR) inhibitor with an IC50 of 0.3 μM. MK 319 can be utilized in diabetes research .
Cat. No.: HY-122177
CAS No.: 314297-32-0
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MK181 is an aldose reductase (AR) inhibitor with IC50s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10 .
Cat. No.: HY-101555
CAS No.: 128851-36-5
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M 16209 is an orally active aldose reductase (AR) inhibitor. M 16209 inhibits partially purified AR from various sources with IC50 values of 0.12, 0.24, 4.5, 1.2 and 9.3 μM for rat lens AR, bovine lens AR, bovine kidney AR, canine lens AR and human placental AR. M 16209 can be used for the research of metabolic disease, such as diabetes .
Cat. No.: HY-50289R
CAS No.: 68367-52-2
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Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway .
Cat. No.: HY-N3716
CAS No.: 517885-72-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
