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antifeedant activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (2) Apoptosis (1) Bacterial (2) Carboxylesterase (CES) (1) DNA Alkylator/Crosslinker (1) Drug Derivative (2) Drug Intermediate (1) Drug Isomer (1) Fungal (1) Herbicide (1) Insecticide (5) Notch (1) Parasite (3) Potassium Channel (1) Reference Standards (1) Tyrosinase (1)
By Research Areas:	Cancer (4) Infection (13) Inflammation/Immunology (2) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3014

Bruceine D 4 Publications Verification	Notch Apoptosis Parasite	Infection Cancer
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity . Bruceine D has strong anthelmintic activity against D. intermedius with an EC₅₀ value of 0.57 mg/L .

HY-W004291

Methyl arachidate Methyl icosanoate	Aminopeptidase	Infection
Methyl arachidate (Methyl icosanoate) is a component of lipid mixtures. Methyl arachidate can be isolated from flowering plants. Methyl arachidate inhibits LTA4H. Methyl arachidate shows no antifeedant activity against Leptinotarsa decemlineata .

HY-N5022

Evolitrine 7-Methoxydictamnine; Evolitrin	Others	Inflammation/Immunology
Evolitrine (7-Methoxydictamnine; Evolitrin) is isolated from Acronychia pedunculata and show anti-inflammatory and antifeedant activities .

HY-111934

Cymarin	Parasite Potassium Channel	Others Cancer
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

HY-W012892

Methylphenylethyne Phenylmethylacetylene	Drug Intermediate	Infection
Methylphenylethyne (Phenylmethylacetylene) is an intermediate of bioactive compounds. Methylphenylethyne has antifeedant activities for larvae of Pieris rapae crucivora. Methylphenylethyne can be used for pest control research .

HY-118401

Mansonone E	Fungal Bacterial Herbicide	Infection
Mansonone E (Compound 5) is a pesticide. Mansonone E can be isolated from heartwood of Mansonia gagei. Mansonone E has significant antifungal activity against Cladosporium cucumerinum, Candida albicans and Phytophthora parasitica. Mansonone E has potent antibacterial activity with MIC₅₀s of both 7.8 μg/mL for Xanthomonas oryzae pv. oryzae and X. oryzae pv. Oryzicola. Mansonone E also has antifeedant and herbicidal activities .

HY-N3068

Picrasin B Nigakilactone I; Simalikalactone B	Others	Others
Picrasin B (Nigakilactone I) can be isolated from the bark of Picrasma quassioides. Picrasin B shows antifeedant and insecticidal activity against Diamondback Moth .

HY-N3291

Methyl-3-(2,4-dihydroxy phenyl) propanoate	Others	Others
Methyl-3-(2,4-dihydroxy phenyl) propanoate is a phenylpropanoic ester with antifeedant activity .

HY-N3970

Gopherenediol	Others	Neurological Disease
Gopherenediol is a diterpenoid with putative antifeedant activity against Mammalian herbivores. Gopherenediol is the active compound in to form deterrent effect, protects gopherweed, Euphorbia lathyris (Euphorbiaceae) from feeding by Mammalian herbivores .

HY-169068

Antifeedant agent 1	Carboxylesterase (CES)	Infection
Antifeedant agent 1 is a carboxylesterase inhibitor that exerts insecticidal activity by inhibiting insect feeding, with an EC₅₀ value of 0.038 mg/mL. Antifeedant agent 1 can be used in research related to pest control .

HY-N1134

(-)-Hinokiresinol Hinokiresinol; trans-Hinokiresinol	Others	Others
(-)-Hinokiresinol (Hinokiresinol; trans-Hinokiresinol) can be isolated from Chamaecyparis obtusa. (-)-Hinokiresinol has weak termiticidal activity but strong antifeedant and repellent activity .

HY-N10831

Ajuganipponin A	Others	Others
Ajuganipponin A is a nature product that could be isolated from the aerial parts of Ajuga nipponensis. Ajuganipponin A has antifeedant activity against larvae of the Egyptian cotton leafworm .

HY-N12875

Ailancoumarin E	Tyrosinase	Others
Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC₅₀ of 14.21 μM .

HY-W004291R

Methyl arachidate (Standard) Methyl icosanoate (Standard)	Reference Standards Aminopeptidase	Infection
Methyl arachidate (Standard) is the analytical standard of Methyl arachidate (HY-W004291). This product is intended for research and analytical applications. Methyl arachidate (Methyl icosanoate) is a component of lipid mixtures. Methyl arachidate can be isolated from flowering plants. Methyl arachidate inhibits LTA4H. Methyl arachidate shows no antifeedant activity against Leptinotarsa decemlineata .

HY-N9401

Azedarachol	Others	Others
Azedarachol possesses antifeedant activity .

HY-N15634

Anticopalic acid	Insecticide	Neurological Disease
Anticopalic acid is a labdane-type diterpenoid insect antifeedant that exhibits dose-dependent antifeedant activity against the fall armyworm (Spodoptera frugiperda). Anticopalic acid can be isolated from Vitex hemsleyi. Anticopalic acid may be involved in neuroreceptor-mediated insect taste regulation and could be used to develop environmentally friendly antifeedants targeting lepidopteran pests .

HY-N18151

Ohchinolide C	Others	Others
Ohchinolide C is a ring C-seco limonoid and insect antifeedant. Ohchinolide C can be found in the root bark of Melia toosendan. Ohchinolide C exerts antifeedant activity against Spodoptera eridania larvae .

HY-N9002

20-Hydroxyaflavinine	Drug Derivative	Others
20-Hydroxyaflavinine is a natural diterpene.

HY-N16837

6''-O-β-D-Apiofuranosylastragalin	Insecticide	Infection
6''-O-β-D-Apiofuranosylastragalin (compound 1) is a flavonoid glycoside that can be naturally extracted from the methanol extract of fresh leaves of Solidago altissima L. (a plant of the genus Solidago in the Asteraceae family). The related methanol extract exhibits *antifeedant* activity against Thrips palmi and can be used in the research of natural antifeedants for agricultural pest control .

HY-N3076

Phyllostine (-)-Phyllostine; Phyllostin	Others	Others
Phyllostine ((-)-Phyllostine) can be isolated from D. miriciae. Phyllostine exhibits strong antifeedant, contact toxicity, and oviposition deterrent activities against P. xylostella .

HY-N18148

Trichilin K	Others	Infection
Trichilin K is a insect antifeeding iimonoid found in the stem bark of Melia toosendan. Trichilin K displays antifeedant activity against Spodoptera eridania larvae .

HY-N18060

Nimbolinin C	Insecticide	Infection
Nimbolinin C is an insect antifeedant present in the unripe fruits of Melia toosendan. Nimbolinin C exhibits weak activity against the feeding behavior of third-instar larvae of Spodoptera exigua at a concentration of 1000 ppm .

HY-N0144A

Isopiperine	Drug Isomer	Infection
Isopiperine is the geometric isomer of Piperine (HY-N0144). Isopiperine can be isolated from pepper. Isopiperine shows antifeedant activity against S. litura with an ED₅₀ of 0.058 (μmol/cm ²) .

HY-N18873

Inulasalsolin	Insecticide	Infection
Inulasalsolin is a insecticide with antifeedant activity, which is isolated from the plant Inula salsoloides. Inulasalsolin reduces the feeding behavior of third-instar Plutella xylostella larvae. Inulasalsolin induces the death of third-instar Plutella xylostella larvae and vegetable aphids. Inulasalsolin is applicable to pest control research .

HY-N17875

Demethylsalvicanol (+)-Demethylsalvicanol	Drug Derivative	Cancer
Demethylsalvicanol ((+)-Demethylsalvicanol), a diterpene, is a anticancer agent with an IC₅₀ of 0.71 μg/mL against P388 murine leukemia cells. Demethylsalvicanol induces cytotoxic activity against leukemia cells and insect Sf9 cells. Demethylsalvicanol acts as an antifeedant against Leptinotarsa decemlineata. Demethylsalvicanol can be used for the research of leukemia .

HY-N9698

1,5-Diphenyl-2-penten-1-one	Others	Others
1,5-Diphenyl-2-penten-1-one is a natural product extracted from Stellera chamaejasme. 1,5-Diphenyl-2-penten-1-one has strong contact activity and very good anti-feedant activity against Aphis gossypii and Schizaphis graminum .

HY-N18288

6''-O-(3'''-Hydroxy-3'''-methylglutaryl) vitexin	Insecticide	Infection
6''-O-(3'''-Hydroxy-3'''-methylglutaryl) vitexin is an orally active flavonoid glycoside and insecticide that can be isolated from the twigs of Eleusine coracana. 6''-O-(3'''-Hydroxy-3'''-methylglutaryl) vitexin exhibits distinct antifeedant activity against Nilaparvata lugens (brown planthopper) nymphs and effectively inhibits their feeding behavior. 6''-O-(3'''-Hydroxy-3'''-methylglutaryl) vitexin can serve as a plant-derived natural defense substance for regulating pest behavior and investigating potential control mechanisms of agricultural pests .

HY-N18080

Parthenin	Parasite DNA Alkylator/Crosslinker Bacterial	Infection Inflammation/Immunology Cancer
Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L. Parthenin induces chromosomal aberrations, mainly chromatid breaks, in human peripheral blood lymphocytes. Parthenin exhibits toxicity against Salmonella typhimurium and Escherichia coli strains, with reduced toxicity in the presence of a metabolic activation system (S9). Parthenin acts as an antifeedant against the 6th instar larvae of the tobacco cutworm (Spodoptera litura). Parthenin shows insecticidal activity against adult cowpea weevils (Callosobruchus maculatus). Parthenin inhibits seed germination and seedling growth of sicklepod (Cassia tora). Parthenin possesses nematicidal activity against the 2nd instar larvae of the southern root-knot nematode (Meloidogyne incognita). Parthenin serves as a research agent for studies related to cancer, malaria, amoebiasis, inflammatory diseases, and bacterial infections .

Bruceine D 4 Publications Verification	Infection Simaroubaceae Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Source Classification Brucea javanica (L.) Merr.	Notch Apoptosis Parasite
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity . Bruceine D has strong anthelmintic activity against D. intermedius with an EC₅₀ value of 0.57 mg/L .

Methyl arachidate Methyl icosanoate	Structural Classification Natural Products other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Aminopeptidase
Methyl arachidate (Methyl icosanoate) is a component of lipid mixtures. Methyl arachidate can be isolated from flowering plants. Methyl arachidate inhibits LTA4H. Methyl arachidate shows no antifeedant activity against Leptinotarsa decemlineata .

Evolitrine 7-Methoxydictamnine; Evolitrin	Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Disease Research Fields Inflammation/Immunology Source Classification	Others
Evolitrine (7-Methoxydictamnine; Evolitrin) is isolated from Acronychia pedunculata and show anti-inflammatory and antifeedant activities .

Cymarin	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Other Diseases Plants Disease Research Fields Apocynum Steroids Source Classification	Parasite Potassium Channel
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

Mansonone E	Malvaceae Mansonia gagei J.R.Drumm. Quinones Structural Classification Plants Naphthalene Quinones Source Classification	Fungal Bacterial Herbicide
Mansonone E (Compound 5) is a pesticide. Mansonone E can be isolated from heartwood of Mansonia gagei. Mansonone E has significant antifungal activity against Cladosporium cucumerinum, Candida albicans and Phytophthora parasitica. Mansonone E has potent antibacterial activity with MIC₅₀s of both 7.8 μg/mL for Xanthomonas oryzae pv. oryzae and X. oryzae pv. Oryzicola. Mansonone E also has antifeedant and herbicidal activities .

Picrasin B Nigakilactone I; Simalikalactone B	Natural Products Simaroubaceae Ketones, Aldehydes, Acids Plants Source Classification Picrasma chinensis P. Y. Chen	Others
Picrasin B (Nigakilactone I) can be isolated from the bark of Picrasma quassioides. Picrasin B shows antifeedant and insecticidal activity against Diamondback Moth .

Methyl-3-(2,4-dihydroxy phenyl) propanoate	Tephrosia villosa (L.) Pers. Phenols Plants Compositae Source Classification	Others
Methyl-3-(2,4-dihydroxy phenyl) propanoate is a phenylpropanoic ester with antifeedant activity .

Gopherenediol	Terpenoids Euphorbia lathylris Linnaeus Diterpenoids Euphorbiaceae Plants Source Classification	Others
Gopherenediol is a diterpenoid with putative antifeedant activity against Mammalian herbivores. Gopherenediol is the active compound in to form deterrent effect, protects gopherweed, Euphorbia lathyris (Euphorbiaceae) from feeding by Mammalian herbivores .

(-)-Hinokiresinol Hinokiresinol; trans-Hinokiresinol	Structural Classification Cupressaceae Stilbenes Chamaecyparis obtusa (Siebold & Zucc.) Endl. Plants Source Classification	Others
(-)-Hinokiresinol (Hinokiresinol; trans-Hinokiresinol) can be isolated from Chamaecyparis obtusa. (-)-Hinokiresinol has weak termiticidal activity but strong antifeedant and repellent activity .

Ajuganipponin A	Portulacaceae Terpenoids Diterpenoids Plants Portulaca oleracea Linn. Source Classification	Others
Ajuganipponin A is a nature product that could be isolated from the aerial parts of Ajuga nipponensis. Ajuganipponin A has antifeedant activity against larvae of the Egyptian cotton leafworm .

Ailancoumarin E	Simaroubaceae Ailanthus altissima (Mill.) Swingle Coumarins Phenylpropanoids Plants Source Classification	Tyrosinase
Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC₅₀ of 14.21 μM .

Methyl arachidate (Standard) Methyl icosanoate (Standard)	Structural Classification Natural Products other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Aminopeptidase
Methyl arachidate (Standard) is the analytical standard of Methyl arachidate (HY-W004291). This product is intended for research and analytical applications. Methyl arachidate (Methyl icosanoate) is a component of lipid mixtures. Methyl arachidate can be isolated from flowering plants. Methyl arachidate inhibits LTA4H. Methyl arachidate shows no antifeedant activity against Leptinotarsa decemlineata .

Azedarachol	Melia azedarach Linn. Classification of Application Fields Other Diseases Plants Disease Research Fields Meliaceae Steroids Source Classification	Others
Azedarachol possesses antifeedant activity .

Anticopalic acid	Structural Classification Ketones, Aldehydes, Acids Labiatae Petasites hybridus (L.) G.Gaertn., B.Mey. & Schreb. Plants Source Classification	Insecticide
Anticopalic acid is a labdane-type diterpenoid insect antifeedant that exhibits dose-dependent antifeedant activity against the fall armyworm (Spodoptera frugiperda). Anticopalic acid can be isolated from Vitex hemsleyi. Anticopalic acid may be involved in neuroreceptor-mediated insect taste regulation and could be used to develop environmentally friendly antifeedants targeting lepidopteran pests .

Ohchinolide C	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	Others
Ohchinolide C is a ring C-seco limonoid and insect antifeedant. Ohchinolide C can be found in the root bark of Melia toosendan. Ohchinolide C exerts antifeedant activity against Spodoptera eridania larvae .

20-Hydroxyaflavinine	Monoterpene Indole Alkaloids Structural Classification Alkaloids Microorganisms Source Classification	Drug Derivative
20-Hydroxyaflavinine is a natural diterpene.

6''-O-β-D-Apiofuranosylastragalin	Structural Classification Flavonoids Flavones Plants Compositae Petalostemun purpureum Source Classification	Insecticide
6''-O-β-D-Apiofuranosylastragalin (compound 1) is a flavonoid glycoside that can be naturally extracted from the methanol extract of fresh leaves of Solidago altissima L. (a plant of the genus Solidago in the Asteraceae family). The related methanol extract exhibits *antifeedant* activity against Thrips palmi and can be used in the research of natural antifeedants for agricultural pest control .

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antifeedant activity

Inhibitors & Agonists

NaturalProducts

Natural
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