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Results for "

antiplasmodial compound

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

7

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7897
    Myrrhone

    		Parasite Infection
    Myrrhone is a terpenoid compound with antiplasmodial effects .
    Myrrhone
  • HY-N3160
    Erythrinasinate B

    Octacosyl (E)-ferulate

    		 Parasite Infection
    Octacosyl (E)-ferulate (Erythrinasinate B) (Compound 1) is an antiplasmodial compound. Octacosyl (E)-ferulate can be isolated from Erythrina .
    Erythrinasinate B
  • HY-N13288
    Cordysinin C/D

    		Parasite Infection
    Cordysinin C/D (compound 9) is a potential anti-plasmodial compound that can effectively inhibit Plasmodium falciparum 3D7 strain .
    Cordysinin C/D
  • HY-N8383
    Butyrolactone V

    		Parasite Infection
    Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC50 of 7.9 µg/ml .
    Butyrolactone V
  • HY-168208
    Antimalarial agent 45

    		Parasite Infection
    Antimalarial agent 45 (compound 8I) is a antimalarial agent and shows antiplasmodial activity the IC50 of 0.21 μM. Antimalarial agent 45 can be used for study of malaria .
    Antimalarial agent 45
  • HY-161171
    Antimalarial agent 37

    		Parasite Ephrin Receptor Cancer
    Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7 .
    Antimalarial agent 37
  • HY-155536
    Antimalarial agent 28

    		Parasite Infection
    Antimalarial agent 28 (Compound 2i) is an antiplasmodial agent. Antimalarial agent 28 inhibits P. berghei, with IC50s of 0.561 μM, 0.14 μM, 4.34 μM for Liver stage, early gametocytes and ring stages of P. falciparum .
    Antimalarial agent 28
  • HY-N8691
    2',6'-Dihydroxy-4'-methoxydihydrochalcone

    		Parasite Infection Inflammation/Immunology
    2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro .
    2',6'-Dihydroxy-4'-methoxydihydrochalcone
  • HY-169922
    HDAC-IN-82

    		HDAC Parasite Caspase Cancer
    HDAC-IN-82 (Compound 18b) is a histone deacetylase (HDAC) inhibitor with selective antiplasmodial and anticancer activity. HDAC-IN-82 shows potent antiproliferative activity and caspase 3/7 activation in cancer cells. HDAC-IN-82 causes hyperacetylation of histone H3 and α-tubulin .
    HDAC-IN-82
  • HY-174325
    Antimalarial agent 50

    		Parasite Infection Inflammation/Immunology
    Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria.
    Antimalarial agent 50
  • HY-155354
    Antimalarial agent 33

    		Parasite Infection
    Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC50 of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .
    Antimalarial agent 33
  • HY-N8374
    Pheanthine

    		Parasite Infection
    Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC50 is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC50 of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC50 is 11.2 μM) and macrophages (PMM, IC50 is 8 μM) .
    Pheanthine
  • HY-174130
    PI4Kβ/PKG-IN-1

    		Parasite PI4K PKG Infection
    PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG). PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria .
    PI4Kβ/PKG-IN-1
  • HY-155054
    Cysteine protease inhibitor-3

    		Parasite Infection
    Cysteine protease inhibitor-3 (Compound 15) is a Cysteine protease inhibitor. Cysteine protease inhibitor-3 inhibits Pf3D7, PfW2, PfFP2 and PfFP3 with IC50s of 0.74 μM, 1.05 μM, 3.5 μM, and 4.9 μM, respectively. Cysteine protease inhibitor-3 has anti-plasmodial efficacy against both drug-sensitive and drug-resistant parasites .
    Cysteine protease inhibitor-3
  • HY-168931
    CCOE-5

    		Parasite Infection
    CCOE-5 is a chalcone compound with antiplasmodial activity, showing an IC50 of 1.4 μg/mL against P. falciparum (3D7), and an IC50 of less than 5 μg/mL against P. falciparum (INDO). CCOE-5 holds promise for research in the field of anti-infective therapies .
    CCOE-5
  • HY-180110
    Antiparasitic agent-32

    		Parasite Lactate Dehydrogenase Infection
    Antiparasitic agent-32 (compound M9), a Piperaquine (HY-B1896) analog, is a potent P. falciparum lactate dehydrogenase (Pf LDH)-targeting antiparasitic agent (Pf3D7 IC50 = 0.40 μM). Antiparasitic agent-32 exhibits significant activity against both Pf asexual and gametocyte stages. Antiparasitic agent-32 exerts antiplasmodial activity through stable and specific noncovalent interactions at the NADH-binding site. Antiparasitic agent-32 can be used for malaria research .
    Antiparasitic agent-32
  • HY-N18091
    Tovophyllin A

    		Akt GSK-3 Keap1-Nrf2 NF-κB Apoptosis Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Tovophyllin A is an orally active xanthonoid compound. Tovophyllin A exerts neuroprotective effects against Parkinson's disease by activating the Akt/GSK3β signaling pathway. Tovophyllin A protects mouse models of liver injury by activating Nrf2. Tovophyllin A exhibits protective anti-inflammatory activity in mouse models of acute lung injury. Tovophyllin A inhibits the activation of NF-κB and subsequent release of pro-inflammatory cytokines. Tovophyllin A reduces apoptotic cell death (Apoptosis). Tovophyllin A has antiplasmodial activity. Tovophyllin A shows cytotoxic activity against lung epithelial cancer cells and breast cancer cells. Tovophyllin A can be used in research related to Parkinson's disease, liver injury, acute lung injury, lung epithelial cancer, and breast cancer .
    Tovophyllin A

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