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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
bioconjugation reactions
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "bioconjugation reactions" in MCE Product Catalog:
8
8 Publications Verification
Synonyms: Disodium bicinchoninate
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BCA is a chelating agent targeting Cu I. BCA forms a water-soluble complex with Cu I at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the Cu I-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. BCA chelates Cu + from proteins that reduce Cu 2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. BCA is a potential small-molecule candidate for AHAS inhibitors .
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8 Publications Verification
Cat. No.: HY-W004599
CAS No.: 1245-13-2
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Bicinchoninic acid is a chelating agent targeting Cu I. Bicinchoninic acid forms a water-soluble complex with Cu I at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the Cu I-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. Bicinchoninic acid chelates Cu + from proteins that reduce Cu 2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. Bicinchoninic acid is a potential small-molecule candidate for AHAS inhibitors .
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8 Publications Verification
Cat. No.: HY-15908A
CAS No.: 63451-34-3
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Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a chelating agent targeting Cu I. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate forms a water-soluble complex with Cu I at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the Cu I-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate chelates Cu + from proteins that reduce Cu 2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a potential small-molecule candidate for AHAS inhibitors .
Synonyms: mPEG550-NH2
Cat. No.: HY-W588704
CAS No.: 54447-68-6
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4-Azidobutyric acid is a click chemistry reagent featuring azide and carboxylic acid moieties. The carboxylic acid group can conjugate with alcohols or amides, while the azide group serves as a click chemistry handle to react with terminal alkynes or strained cyclooctynes. 4-Azidobutyric acid also acts as a PROTAC linker for the synthesis of PROTACs .
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11-Azidoundecanoic acid is a click chemistry reagent containing an azide group. 11-Azidoundecanoic acid acts as a hydrophobic bioconjugation linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. 11-Azidoundecanoic acid is substrate of lipoic acid ligase (LpIA) for labeling . 11-Azidoundecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-W190824
CAS No.: 2363756-34-5
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Biotin-PEG8-azide is a bioconjugation reagent. Biotin-PEG8-azide consists of biotin, PEG8 linker and azide group and serves as a modifying linker in click reactions. Biotin-PEG8-azide can be used for research related to click chemistry .
Cat. No.: HY-W879048
CAS No.: 2924872-84-2
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DBCO-PEG24-Maleimide is a bioconjugation reagent. DBCO-PEG24-Maleimide contains a DBCO group, a maleimide group, and a PEG segment with 24 repeating units. DBCO-PEG24-Maleimide mediates strain-promoted azide-alkyne cycloaddition and maleimide-thiol conjugation reactions, thereby conjugating SpCas9 variants to DN1S and IPP2 protein domains .
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H-L-Lys (4-N3-Z)-OH hydrochloride is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. H-L-Lys (4-N3-Z)-OH hydrochloride enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. H-L-Lys (4-N3-Z)-OH hydrochloride serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions .
Cat. No.: HY-160841
CAS No.: 2567941-52-8
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Biotin-16-dCTP is a biotinylated deoxycytidine triphosphate that serves as an important DNA labeling substrate. Biotin-16-dCTP can be enzymatically incorporated into the 3' end of DNA probes via terminal deoxynucleotidyl transferase, forming a 1-3 nucleotide-long tail to achieve biotinylation of the probes. Biotin-16-dCTP enhances chemiluminescent detection of low-abundance targets such as specific tRNA isoacceptors through Northern blotting. Biotin-16-dCTP can also replace conventional dCTP to be integrated into single-stranded DNA generated by asymmetric polymerase chain reaction, which is applicable for bioconjugation or pull-down assays. Repeated freeze-thaw cycles of Biotin-16-dCTP should be avoided to prevent degradation of its function for probe biotinylation .
Cat. No.: HY-W190755
CAS No.: 87135-00-0
Cat. No.: HY-118112
CAS No.: 64191-06-6
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4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.
Cat. No.: HY-154835
CAS No.: 1513855-74-7
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N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine is an unnatural lysine analog and a substrate of the PABKRS mutant PylRS. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine enables site-specific genetic integration into proteins via amber stop codon suppression; it undergoes Staudinger reduction with phosphine compounds, followed by a self-elimination reaction to release native lysine. N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine serves as a genetically encoded element for the temporal chemical control of protein SUMOylation and nuclear translocation in living mammalian cells, and also acts as a bioorthogonal reaction handle for bioconjugation reactions .
Cat. No.: HY-W190746
CAS No.: 123687-40-1
Cat. No.: HY-W440904
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DSPE-PEG1000-Vinylsulfone is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine.
Cat. No.: HY-W440905
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DSPE-PEG2000-Vinylsulfone is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine.
Cat. No.: HY-W440907
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DSPE-PEG5000-Vinylsulfone is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine.
Cat. No.: HY-D3501
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5-FAM BCN is a reactive fluorophore-labeled strained alkyne probe and bicyclononyne. 5-FAM BCN undergoes inverse-electron-demand Diels-Alder cycloaddition with five-membered cyclic dienes. 5-FAM BCN facilitates bioorthogonal bioconjugation reactions .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
