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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
cell-free kinase assay
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "cell-free kinase assay" in MCE Product Catalog:
Cat. No.: HY-123597
CAS No.: 15427-93-7
Synonyms: DDUG; NCI C04808
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NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2; IC50=200 nM in a cell-free kinase assay). It is selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK with IC50 values of 210, 6,000, 7,400, and 7,100 nM, respectively. NSC 109555 inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC50=240 nM). It inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro.2 NSC 109555 (1,250 nM) potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of reactive oxygen species (ROS) in MIA PaCa-2 cells.
Cat. No.: HY-145045
CAS No.: 2403598-42-3
HPK1-IN-18 is an HPK1 kinase inhibitor with anticancer cell activity. HPK1-IN-18 inhibits HPK1 kinase activity. HPK1-IN-18 can be used for cancer research .
Cat. No.: HY-116153
CAS No.: 1393102-59-4
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HUHS2002 is a free fatty acid derivative with the ability to enhance α7 cholinergic receptor activity. HUHS2002 enhances whole-cell membrane currents of α7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner. The effects of HUHS2002 were blocked in the presence of the Ca2 /calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. HUHS2002 activated CaMKII in cultured rodent hippocampal neurons, and this activation was abolished by KN-93. HUHS2002 also partially inhibited the activity of protein phosphatase 1 (PP1) in a cell-free PP1 activity assay .
Cat. No.: HY-W150222
CAS No.: 4994-89-2
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LIMK1-IN-3 is a LIMK1 inhibitor with an IC50 of 4.4 μM. LIMK1-IN-3 shows potential for use in cancer-related research .
Cat. No.: HY-183534
CAS No.: 328061-33-2
CDK2-IN-58 is a selective cyclin-dependent kinase 2 (CDK2) inhibitor with an IC50 of 0.21 μM. CDK2-IN-58 can be used for cancer research .
Cat. No.: HY-184862
CAS No.: 1613711-28-6
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SIK2-IN-5 is a SIK family kinase inhibitor, with IC50 values of 0.1-1 μM against SIK2 and SIK3, and an IC50 value of >1 μM against SIK1. SIK2-IN-5 inhibits the kinase activities of SIK1, SIK2 and SIK3. SIK2-IN-5 can be used in the research of ovarian cancer and breast cancer .
Cat. No.: HY-179400
CAS No.: 1062368-51-7
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LDN-193688 (Compound 26) is a ALK2 inhibitor, with IC₅₀ values of 104, 18, 235, 1530, and 1080 nM against ALK1, ALK2, ALK3, ALK4, and ALK5, respectively. LDN-193688 inhibits bone morphogenetic protein 4 (BMP4)-induced phosphorylation of SMAD1/5/8, with an IC₅₀ of 2.6 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
