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Cat. No.: HY-183534

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CDK2-IN-58

CDK2-IN-58 is a selective cyclin-dependent kinase 2 (CDK2) inhibitor with an IC₅₀ of 0.21 μM. CDK2-IN-58 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 328061-33-2
Formula: C₁₈H₁₅N₅
Molecular Weight:301.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK2-IN-58 Chemical Structure

CAS No.: 328061-33-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CDK2-IN-58 is a selective cyclin-dependent kinase 2 (CDK2) inhibitor with an IC₅₀ of 0.21 μM. CDK2-IN-58 can be used for cancer research^[1].

IC₅₀ & Target^[1]

CDK2

0.21 μM (IC₅₀)

All CDK Isoforms :

In Vitro

CDK2-IN-58 (Compound 1a) inhibits CDK2-cyclin E enzyme activity with an IC₅₀ of 0.21 μM in a cell-free scintillation proximity assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 328061-33-2
Molecular Weight 301.35
Formula C₁₈H₁₅N₅
SMILES

N1=CC=C(N=C1NC=2C=CC=CC2)C3=C(N=C4C=CC=CN43)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Byth KF, et al. Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2004 May 3;14(9):2245-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CDK2-IN-58

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CDK2-IN-58 Related Classifications

HY-183534 Related Classifications