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Cat. No.: HY-W150222

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LIMK1-IN-3

LIMK1-IN-3 is a LIMK1 inhibitor with an IC₅₀ of 4.4 μM. LIMK1-IN-3 shows potential for use in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 4994-89-2
Formula: C₈H₉N₃S
Molecular Weight:179.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LIMK1-IN-3 Chemical Structure

CAS No.: 4994-89-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

LIMK1-IN-3 is a LIMK1 inhibitor with an IC₅₀ of 4.4 μM. LIMK1-IN-3 shows potential for use in cancer-related research^[1].

IC₅₀ & Target

^[1]

LIMK1

4.4 μM (IC₅₀)

All LIM Kinase (LIMK) Isoforms :

LIMK1
LIMK2

In Vitro

LIMK1-IN-3 (compound 12) inhibits purified LIMK1 kinase with an IC₅₀ of 4.4 μM in cell-free KinaseGlo and TR-FRET assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 4994-89-2
Molecular Weight 179.24
Formula C₈H₉N₃S
SMILES

N=1C=NC(N)=C2C1SC(=C2C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sleebs BE, et al. Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5992-4. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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