Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

  • Bioorg Med Chem Lett. 2011 Oct 1;21(19):5992-4. doi: 10.1016/j.bmcl.2011.07.050.
Brad E Sleebs  1 ,  George Nikolakopoulos ,  Ian P Street ,  Hendrik Falk ,  Jonathan B Baell
Affiliations
  • 1. The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
PMID: 21852129 DOI: 10.1016/j.bmcl.2011.07.050
Abstract

4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d]pyrimidines with low micromolar inhibition of LIMK1.

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