Search Result

Results for "

central nervous system agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (6) Akt (1) Amyloid-β (1) Apoptosis (8) Autophagy (2) Bacterial (3) Biochemical Assay Reagents (4) Calcium Channel (1) Caspase (1) CD20 (1) Cholinesterase (ChE) (1) Cytochrome P450 (2) DNA/RNA Synthesis (4) Dopamine Receptor (1) Drug Derivative (2) Drug Metabolite (1) Endogenous Metabolite (7) Environmental Pollutants (2) Fungal (2) GABA Receptor (1) HDAC (1) Heme Oxygenase (HO) (1) Histamine Receptor (6) Influenza Virus (2) Isotope-Labeled Compounds (1) MMP (4) NF-κB (4) P2X Receptor (4) Parasite (1) Phosphodiesterase (PDE) (1) Phytohormone (1) Reference Standards (9) Sodium Channel (1) TRP Channel (1) γ-secretase (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (5) Endocrinology (8) Infection (6) Inflammation/Immunology (18) Metabolic Disease (2) Neurological Disease (26)

By Targets:

Adrenergic Receptor (6)

Akt (1)

Amyloid-β (1)

Apoptosis (8)

Autophagy (2)

Bacterial (3)

Biochemical Assay Reagents (4)

Calcium Channel (1)

Caspase (1)

CD20 (1)

Cholinesterase (ChE) (1)

Cytochrome P450 (2)

DNA/RNA Synthesis (4)

Dopamine Receptor (1)

Drug Derivative (2)

Drug Metabolite (1)

Endogenous Metabolite (7)

Environmental Pollutants (2)

Fungal (2)

GABA Receptor (1)

HDAC (1)

Heme Oxygenase (HO) (1)

Histamine Receptor (6)

Influenza Virus (2)

Isotope-Labeled Compounds (1)

MMP (4)

NF-κB (4)

P2X Receptor (4)

Parasite (1)

Phosphodiesterase (PDE) (1)

Phytohormone (1)

Reference Standards (9)

Sodium Channel (1)

TRP Channel (1)

γ-secretase (1)

By Research Areas:

Cancer (15)

Cardiovascular Disease (5)

Endocrinology (8)

Infection (6)

Inflammation/Immunology (18)

Metabolic Disease (2)

Neurological Disease (26)

Inhibitors & Agonists

Screening Libraries

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-N0035

Arctigenin Maximum Cited Publications 15 Publications Verification (-)-Arctigenin	MMP Influenza Virus Autophagy Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-B0725

Doxepin Hydrochloride 5+ Cited Publications	Histamine Receptor Cytochrome P450	Neurological Disease Cancer
Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant . . Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system . . Doxepin has also been proposed as a protective factor against oxidative stress . .

HY-108652

α,β-Methylene-ATP trisodium 1 Publications Verification	P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP trisodium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP trisodium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP trisodium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP trisodium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system .

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0900

Anethole 2 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Environmental Pollutants Apoptosis NF-κB Fungal Bacterial MMP	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-107790

5-Methoxyflavone 2 Publications Verification	DNA/RNA Synthesis	Neurological Disease
5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABA_A receptors.

HY-W019815

N-Ethyl-N-nitrosourea ENU; N-Nitroso-N-ethylurea	DNA/RNA Synthesis	Neurological Disease Cancer
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders .

HY-B0971

Pheniramine maleate Prophenpyridamine maleate; Tripoton maleate	Histamine Receptor Apoptosis	Inflammation/Immunology Endocrinology
Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-134440A

α,β-Methylene-ATP	P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system .

HY-108335

Sipatrigine 1 Publications Verification 619C89; BW 619C89	Sodium Channel Calcium Channel	Neurological Disease
Sipatrigine (619C89), a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has the potential in the study for focal cerebral ischemia and stroke .

HY-134042

G 130	Drug Derivative	Neurological Disease
GP130 (G130) is a psychostimulant agent, exhibiting antagonist activity against central nervous system depressing agents ^[2.

HY-115726

FRM-024	γ-secretase Amyloid-β	Neurological Disease
FRM-024 is a central nervous system-penetrant, orally active γ-secretase modulator and Aβ42 lowering agent. FRM-024 is used for the research of familial Alzheimer's disease .

HY-119974

Caracemide NSC-253272	DNA/RNA Synthesis Bacterial	Infection Cancer
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity .

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0971A

Pheniramine Prophenpyridamine; Tripoton; Pheniramine solution	Histamine Receptor Apoptosis	Inflammation/Immunology Cancer
Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-19699

1-Naphthylacetamide NAAM; 1-Naphthaleneacetamide; α-Naphthylacetamide	Environmental Pollutants Phytohormone	Neurological Disease Endocrinology
1-Naphthylacetamide is an orally active *nonsteroidal anti-inflammatory agent* (NAIA)** and also an indole-type auxin plant growth regulator. 1-Naphthylacetamide inhibits inflammatory response-related pathways and modulates plant hormone signaling, exhibiting anti-inflammatory, local anesthetic, antispasmodic, analgesic, and diuretic activities. 1-Naphthylacetamide promotes plant cell expansion, differentiation, and fruit enlargement. Additionally, 1-Naphthylacetamide induces central nervous system (CNS) depression in mice, characterized by reduced spontaneous activity, decreased irritability, decreased muscle tone, and attenuated ear-cuff reflex, ipsilateral flexor reflex, and corneal reflex ^[1][2].

HY-115139

Fenadiazole	Others	Neurological Disease
Fenadiazole acts as a central nervous system agent to manage insomnia and dreaminess .

HY-N0035R

Arctigenin (Standard) (-)-Arctigenin (Standard)	Reference Standards MMP Influenza Virus Autophagy Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-174339

Neuroprotective agent 12	Phosphodiesterase (PDE) Heme Oxygenase (HO) NF-κB	Neurological Disease Inflammation/Immunology
Neuroprotective agent 12 is an orally active and BBB-penetrable neuroprotective agent. Neuroprotective agent 12 has potent neuroprotective effects with robust anti-oxidation and anti-inflammation. Neuroprotective agent 12 significantly inhibits glutamate- and acrolein-induced cell death, reduces PDE4B expression but increases the HO-1, p-CREB and BDNF levels. Neuroprotective agent 12 exhibits potent neuroprotection in traumatic brain injury (TBI) mice model, promising for TBI and other central nervous system diseases .

HY-B0900R

Anethole (Standard) Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)	Apoptosis Fungal Bacterial MMP NF-κB Reference Standards	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-134440

α,β-Methylene-ATP dilithium	P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP dilithium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP dilithium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP dilithium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP dilithium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system .

HY-124382

AS1928370	TRP Channel	Neurological Disease
AS1928370 is a novel and central nervous system (CNS) penetrant TRPV1 antagonist and can prevent ligand-induced activation in vivo. AS1928370 is a promising agent for neuropathic pain research .

HY-163629

Anticancer agent 224	Drug Derivative	Cancer
Anticancer agent 224 (Compound 16) is an anticancer agent that can effectively inhibit the growth of central nervous system (CNS), kidney and breast cancer cell, with a GI₅₀ value ranging from 0.6 to 12.8 μM .

HY-135563

Oxoprolintane	Drug Metabolite	Neurological Disease
Oxoprolintane is a metabolite of the psychoactive compound Prolintane (HY-124217). Oxoprolintane has a role in regulating the central nervous system and may be a potential neuroprotective agent. Oxoprolintane is expected to be used in research on neurological diseases .

HY-121670

Ambenoxan	Others	Neurological Disease
Ambenoxan is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.

HY-121670A

Ambenoxan hydrochloride	Adrenergic Receptor	Neurological Disease
Ambenoxan hydrochloride is a central nervous system-acting skeletal muscle relaxant that is effective in mice, rats, rabbits, dogs, and monkeys without loss of the righting reflex. It has no peripheral neuromuscular blocking effects and significantly reduces or eliminates decerebrate rigidity in rabbits, but does not antagonize the effects of strychnine, leptazol, or tremorine. Like other central nervous system depressants, ambenoxan prolongs sleep duration with hexobarbitone, but it has no local anesthetic effects. In anesthetized cats, the agent lowers blood pressure and reduces the pressor response to epinephrine, but has no effect on norepinephrine.

HY-149980

DCN-83	Parasite	Infection
DCN-83, an anti-leishmania agent, is most potent against the amastigote form with an IC₅₀ of 0.71 μM. DCN-83 has the potential to cross the blood-brain barrier and central nervous system .

HY-117471

Antiarrhythmic agent-3	Endogenous Metabolite	Neurological Disease
Antiarrhythmic agent-3 is an antiarrhythmic drug with the activity of enhancing antiarrhythmic efficacy and improving inhibition index. The antiarrhythmic effect of antiarrhythmic agent-3 is related to its hydrophobicity (log P). The central nervous system toxicity of antiarrhythmic agent-3 is related to the combined effect of its hydrophobicity and acid constant (pKa) .

HY-19262

TAK-218	Dopamine Receptor	Neurological Disease Inflammation/Immunology
TAK-218 is a promising candidate as an agent tor central nervous system trauma and ischemia. TAK-218 exhibits potent scavenging activity and antioxidative activity. TAK-218 also inhibits dopamine release .

HY-B0225AS

Methyldopa-d3 hydrochloride L-(-)-α-Methyldopa-d3 hydrochloride; MK-351-d3 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225BR

Methyldopa hydrate (Standard) L-(-)-α-Methyldopa hydrate (Standard); MK-351 hydrate (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0971R

Pheniramine maleate (Standard) Prophenpyridamine maleate (Standard); Tripoton maleate (Standard); Pheniramine maleate (Standard)	Reference Standards Histamine Receptor Apoptosis	Inflammation/Immunology Endocrinology
Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-N7814R

2-Hydroxypalmitic acid (Standard)	Reference Standards Endogenous Metabolite	Others
Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-B0971AR

Pheniramine (Standard) Prophenpyridamine (Standard); Tripoton (Standard); Pheniramine solution (Standard)	Reference Standards Histamine Receptor Apoptosis	Inflammation/Immunology Cancer
Pheniramine (Standard) is the analytical standard of Pheniramine. This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-153127

Florbenazine AV-133	Biochemical Assay Reagents	Neurological Disease
Florbenazine (AV-133) is a diagnostic imaging agent targeting the central nervous system monoamine transporter VMAT2, and its F-18 labeled form can be used for PET scanning. The biodistribution of [18F]Florbenazine in mice shows a high striatum/cerebellum ratio (0.48), which can be used for the diagnostic research of neurodegenerative diseases (including dementia with Lewy bodies and Parkinson's disease) .

HY-B0725R

Doxepin Hydrochloride (Standard)	Reference Standards Histamine Receptor Cytochrome P450	Neurological Disease Cancer
Doxepin (Hydrochloride) (Standard) is the analytical standard of Doxepin (Hydrochloride). This product is intended for research and analytical applications. Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant . . Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system . . Doxepin has also been proposed as a protective factor against oxidative stress . .

HY-137055

PF-3774076	Others	Others
PF-3774076 is a highly central nervous system (CNS) penetrant, potent, and selective human α1A-adrenoceptor partial agonist. It exhibits good potency and selectivity in multiple binding and functional assays. PF-3774076 increases peak urethral pressure in anesthetized female dogs in a dose-dependent manner via a central mechanism. PF-3774076 affects both the proximal and distal portions of the urethra in vivo. These properties suggest that PF-3774076 may have significant benefit in the treatment of stress urinary incontinence (SUI) as a CNS-penetrant α1A receptor partial agonist. However, despite its partial agonism and selectivity for α1A receptors, PF-3774076 failed to provide adequate safety differences in in vivo models of cardiovascular function. This may be due to the simultaneous activation of both peripheral and central α1A receptors. These data suggest that while central α1A partial agonists may have significant benefit in the treatment of SUI, this class of agents may have difficulty achieving the desired urethral selectivity without affecting cardiovascular function.

HY-167649

Poskine	Cholinesterase (ChE)	Neurological Disease
Poskine is an anticholinergic agent and a central nervous system depressant. Poskine can be utilized in research related to Parkinson's disease and travel sickness .

HY-A0202

NSC-224070	Biochemical Assay Reagents	Neurological Disease Cancer
NSC-224070 is a diaziridinyl benzoquinone alkylating agent. NSC-224070 can be used for research on central nervous system tumors .

HY-185401A

(E,E)-ATSM	Biochemical Assay Reagents	Neurological Disease
(E,E)-ATSM is a chelating agent. (E,E)-ATSM can react with the metallized ligand Copper gluconate. (E,E)-ATSM can be used in research on central nervous system diseases .

HY-183671

NSC850143	Biochemical Assay Reagents	Inflammation/Immunology Cancer
NSC850143 is an antiproliferative agent. NSC850143 induces antiproliferative and cytotoxic effects in aggressive tumor cells. NSC850143 can be used in the research of cancers such as leukemia, non-small cell lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer .

HY-A0177

Fominoben	GABA Receptor	Inflammation/Immunology
Fominoben is a type of benzamide-based antitussive agent. Fominoben works by acting on the central nervous system to increase alveolar ventilation, thereby improving the blood oxygen levels in patients with pulmonary diseases (COLD). Fominoben can bind to the benzodiazepine receptor binding sites in the brain and also has anti-anxiety and anti-convulsant effects. Fominoben can be used in research on hypoxemia.

HY-107790R

5-Methoxyflavone (Standard)	Reference Standards DNA/RNA Synthesis	Neurological Disease
5-Methoxyflavone (Standard) is the analytical standard of 5-Methoxyflavone (HY-107790). This product is intended for research and analytical applications. 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.

HY-108652R

α,β-Methylene-ATP trisodium (Standard)	Reference Standards P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP trisodium (Standard) is the analytical standard of α,β-Methylene-ATP (trisodium) (HY-108652). This product is intended for research and analytical applications. α,β-Methylene-ATP trisodium is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP trisodium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP trisodium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP trisodium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system .

HY-183366

HDAC1-IN-14	HDAC Caspase Akt	Inflammation/Immunology Cancer
HDAC1-IN-14 is an indole-based benzamide selective HDAC1 inhibitor with an IC₅₀ of 77 nM. HDAC1-IN-14 acts as an antiproliferative agent, with GI₅₀ values ranging from nanomolar to low micromolar levels in various cancer cells. HDAC1-IN-14 induces G0-G1 cell cycle arrest in colon cancer cells. HDAC1-IN-14 upregulates the expression of Caspase-3, Cyto-C and Bax, and downregulates the expression of AKT-1. HDAC1-IN-14 can be used in research related to leukemia, non-small cell lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer .

HY-P992060

Anti-Mouse CD20 Antibody (18B12)	CD20 NF-κB	Inflammation/Immunology Cancer
Anti-Mouse CD20 Antibody (18B12) is a B cell depleting agent that targets mouse CD20. Anti-Mouse CD20 Antibody (18B12) not only inhibits the growth of mesothelioma, lung cancer and thymoma, but also significantly enhances the efficacy of adenoviral tumor antigen vaccines and induces tumor regression by increasing the number of tumor-specific CD8 ⁺ T cells. Anti-Mouse CD20 Antibody (18B12) reduces B cell infiltration into the central nervous system of mice with experimental autoimmune encephalomyelitis, and delays motor dysfunction and neuronal death after spinal cord injury by alleviating inflammatory responses and tissue damage. Anti-Mouse CD20 Antibody (18B12) is widely applicable to research in fields related to mesothelioma, lung cancer, thymoma, experimental autoimmune encephalomyelitis and spinal cord injury .

HY-N18124

1-O-Tigloyl-1-O-debenzoylohchinal	Others	Neurological Disease
1-O-Tigloyl-1-O-debenzoylohchinal is an orally active limonoid-type triterpenoid anti-inflammatory and peripheral analgesic agent isolated from the fruits of Melia toosendan. 1-O-Tigloyl-1-O-debenzoylohchinal significantly inhibits acetic acid (HY-Y0319)-induced increase in vascular permeability, λ-Carrageenan (HY-N9470)-induced paw edema, and acetic acid-induced writhing response in mice. 1-O-Tigloyl-1-O-debenzoylohchinal shows no significant analgesic effect in the hot-plate test, and acts mainly on the peripheral rather than the central nervous system. 1-O-Tigloyl-1-O-debenzoylohchinal can be widely used in the research of acute or chronic inflammation, stomachache and other related diseases .

Cat. No.	Product Name

HY-L121

5-HT Receptor Compound Library

405 compounds

5-HT receptors, also called Serotonin receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. These receptors are now classified into seven families, 5-HT1–7, comprising a total of 14 structurally and pharmacologically distinct mammalian 5-HT receptor subtypes. The 5-HT receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

MCE 5-HT Receptor Compound Library consists of 405 5-HT receptor inhibitors and activators, which can be used for neuropsychiatric disorders drugs discovery.

Cat. No.	Product Name	Target	Research Area	Image