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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
chorea
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "chorea" in MCE Product Catalog:
Cat. No.: HY-B0590B
CAS No.: 1026016-83-0
Synonyms: (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine
Target:
Research Areas:
(+)-Tetrabenazine ((+)-TBZ) is the enantiomer of Tetrabenazine (HY-B0590) and is also a Vesicular Monoamine Transporter 2 (VMAT2) inhibitor with a rat Ki of 4.61 nM. (+)-Tetrabenazine inhibits monoamine uptake into granular vesicles of presynaptic neurons. (+)-Tetrabenazine is 3 times more active than (-)-Tetrabenazine. (+)-Tetrabenazine can be used for the research of Huntington's disease and hyperkinetic movement disorders (including chorea) .
Cat. No.: HY-G0025
CAS No.: 924854-60-4
Synonyms: (-)-β-Dihydrotetrabenazine; (-)-β-HTBZ
Target:
Research Areas:
Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM) . Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders .
Cat. No.: HY-158339
CAS No.: 3034510-43-2
Target:
Research Areas:
ABHD antagonist 2 (Compound 9) is an antagonist for alpha/beta-Hydrolase domain containing 6 (ABHD6), with IC50 <0.001 μM. ABHD antagonist 2 exhibits good binding ability with ABHD6, with IC50 of 0.002 μM .
Cat. No.: HY-141554A
CAS No.: 862377-27-3
Synonyms: (2S,3S,11bR)-DHTBZ
Target:
Research Areas:
(2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR)-Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR)-Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders .
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
ASN04421891 is a GPR17 agonist with nanomolar EC50 and high specificity. ASN04421891 promotes oligodendrocyte precursor cell maturation to mature myelinating oligodendrocytes. ASN04421891 can be used for the research of cerebral ischaemia, cardiac ischaemia, renal ischaemia, cerebral trauma, multiple sclerosis, schizophrenia, depression, alzheimer's disease, alzheimer-like dementia, parkinson's disease, huntington's chorea, amyotrophic lateral sclerosis (ALS), neuroinflammatory disorders .
Cat. No.: HY-110255C
CAS No.: 934282-57-2
Target:
Research Areas:
AZD 2066 sulfate is a mGluR5 antagonist and also the sulfate salt of 4-(5-{(1R)-1-ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl) pyridine. AZD 2066 sulfate is used in research on various diseases including Alzheimer's disease, autism, and obesity .
Cat. No.: HY-156505A
CAS No.: 2488764-06-1
Target:
Research Areas:
R-(+)-EU-1180-453 is a positive allosteric modulator targeting NMDA receptors containing GluN2C and GluN2D subunits, with a pEC50 value of 5.5 for both rat receptor subtypes, and it can cross the blood-brain barrier. R-(+)-EU-1180-453 increases the potency of glutamate, enhances receptor responses to maximally effective concentrations of agonists, and acts only on receptors bound to both co-agonists. R-(+)-EU-1180-453 is applicable to research related to Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain .
Cat. No.: HY-P86917
Synonyms: AV026640 antibody; BCH antibody; Benign chorea antibody; BHC antibody; Homeobox protein NK 2 homolog A antibody; Homeobox protein NK-2 homolog A antibody; Homeobox protein Nkx 2.1 antibody; Homeobox protein Nkx-2.1 antibody; Homeobox protein Nkx2.1 antibody; NK 2 antibody; AV026640 antibody; BCH antibody; Benign chorea antibody; BHC antibody; Homeobox protein NK 2 homolog A antibody; Homeobox protein NK-2 homolog A antibody; Homeobox protein Nkx 2.1 antibody; Homeobox protein Nkx-2.1 antibody; Thyroid transcription factor 1 antibody; Tin man antibody; Tinman antibody; TITF 1 antibody; TITF1 antibody; TTF 1 antibody; TTF-1 antibody; TTF1 antibody
Cat. No.: HY-P85945
Synonyms: AV026640; BCH; Benign chorea; BHC; Homeobox protein NK 2 homolog A; Homeobox protein NK-2 homolog A; Homeobox protein Nkx 2.1; Homeobox protein Nkx-2.1; Homeobox protein Nkx2.1; NK 2; NK 2 homolog A; NK2; NK2 homeobox 1; NK2, drosophila, homolog of, A; NK2.1, Mouse, homolog of; Nkx 2 1; NKX 2.1; NKX 2A; NKX2 1; Nkx2-1; NKX2.1; NKX21_HUMAN; NKX2A; T EBP; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid nuclear factor; Thyroid specific enhancer binding protein; Thyroid transcription factor 1; Tin man; Tinman; TITF 1; TITF1; TTF 1; TTF-1; TTF1
Cat. No.: HY-P86155
Synonyms: AV026640; BCH; Benign chorea; BHC; Homeobox protein NK 2 homolog A; Homeobox protein NK-2 homolog A; Homeobox protein Nkx 2.1; Homeobox protein Nkx-2.1; Homeobox protein Nkx2.1; NK 2; NK 2 homolog A; NK2; NK2 homeobox 1; NK2, drosophila, homolog of, A; NK2.1, Mouse, homolog of; Nkx 2 1; NKX 2.1; NKX 2A; NKX2 1; Nkx2-1; NKX2.1; NKX21_HUMAN; NKX2A; T EBP; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid nuclear factor; Thyroid specific enhancer binding protein; Thyroid transcription factor 1; Tin man; Tinman; TITF 1; TITF1; TTF 1; TTF-1; TTF1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
