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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
chromosome alignment
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "chromosome alignment" in MCE Product Catalog:
1
1 Cited Publications
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Research Areas:
FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .
Synonyms: KIF18A-IN-7
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Research Areas:
VLS-1272 (Compound 22) is an orally active KIF18A inhibitor that binds to the KIF18A-microtubule complex in an ATP-noncompetitive manner (IC50 = 41 nM), blocking its ATPase activity and inhibiting microtubule translocation. This leads to abnormal accumulation of KIF18A at spindle poles, disrupting chromosome alignment and inducing mitotic arrest and apoptosis in CIN High tumor cells (e.g., ovarian cancer OVCAR-3, breast cancer JIMT-1). VLS-1272 is a promising candidate for anti-tumor research .
Cat. No.: HY-124519
CAS No.: 331749-88-3
Synonyms: Cent-1
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Research Areas:
Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates microtubule plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint .
Cat. No.: HY-189647
CAS No.: 3120750-94-6
KIF18A-IN-20 is an orally active KIF18A inhibitor with an IC50 of 52 nM. KIF18A-IN-20 targets the plus-end-directed mitotic kinesin KIF18A, regulating chromosome alignment and spindle dynamics, and inhibits the proliferation of chromosomally unstable OVCAR-3 ovarian cancer cells with EC50 = 3.4 nM. KIF18A-IN-20 achieves tumor regression in xenograft models without causing body weight loss. KIF18A-IN-20 can be used for research related to ovarian cancer .
Cat. No.: HY-125106
CAS No.: 1446399-26-3
CENP-E-IN-1 is a CENP-E inhibitor. CENP-E-IN-1 acts as a Mitotic arrest inducer and Apoptosis inducer, which causes abnormal alignment of chromosomes on the metaphase plate, activates the spindle assembly checkpoint and triggers apoptosis. CENP-E-IN-1 exhibits anti-tumor activity in colorectal adenocarcinoma xenograft models. CENP-E-IN-1 can be used in cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
