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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
chronic constipation
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "chronic constipation" in MCE Product Catalog:
5
5 Cited Publications
製品番号: HY-17638
CAS 番号: 666843-10-3
別名: DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base
Target:
研究分野:
Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation .
4
4 Cited Publications
Target:
研究分野:
Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer .
4
Target:
研究分野:
Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer .
2
2 Cited Publications
製品番号: HY-17584
CAS 番号: 851199-59-2
Target:
研究分野:
2
2 Cited Publications
製品番号: HY-17584A
CAS 番号: 851199-60-5
Target:
研究分野:
1
研究分野:
Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .
1
Elobixibat (A 3309; AZD 7806) is an orally active, bile acid transporter (IBAT) inhibitor with IC50 values ??of 0.53 nM (human IBAT), 0.13 nM (mouse IBAT), and 5.8 nM (canine IBAT). Elobixibat can lower LDL cholesterol, increase serum GLP-1, promote colonic motility, and has the potential to study metabolic syndrome. Elobixibat can be used in the study of chronic functional constipation (CIC), dyslipidemia, non-alcoholic hepatitis, and liver tumors in the elderly .
1
1 Cited Publications
別名: A 3309 hydrate; AZD 7806 hydrate
Elobixibat (A 3309; AZD 7806) hydrate is an orally active, bile acid transporter (IBAT) inhibitor with IC50 values ??of 0.53 nM (human IBAT), 0.13 nM (mouse IBAT), and 5.8 nM (canine IBAT). Elobixibat hydrate can lower LDL cholesterol, increase serum GLP-1, promote colonic motility, and has the potential to study metabolic syndrome. Elobixibat hydrate can be used in the study of chronic functional constipation (CIC), dyslipidemia, non-alcoholic hepatitis, and liver tumors in the elderly .
1
1 Cited Publications
Target:
研究分野:
DS-3801b is a potent and non-macrolide agonist of GPR38. DS-3801b is expected to be novel gastrointestinal prokinetic agents for the research of functional gastrointestinal disorders such as gastroparesis and chronic constipation .
Target:
Target:
Lactitol (D-Lactitol) is a non-absorbable disaccharide and Bacterial regulator. Lactitol reduces the populations of Bacteroides, Clostridium, coliforms and Eubacterium, while increasing the populations of Lactobacillus and Streptococcus. Lactitol can be used in the research of portosystemic encephalopathy and chronic constipation .
製品番号: HY-B1389
CAS 番号: 81025-04-9
別名: D-Lactitol monohydrate
Target:
Lactitol monohydrate (D-Lactitol monohydrate) is a non-absorbable disaccharide and Bacterial regulator. Lactitol monohydrate reduces the populations of Bacteroides, Clostridium, coliforms and Eubacterium, while increasing the populations of Lactobacillus and Streptococcus. Lactitol monohydrate can be used in the research of portosystemic encephalopathy and chronic constipation .
製品番号: HY-107929
CAS 番号: 37286-92-3
別名: Poly(styrenesulfonic acid) calcium salt
Target:
研究分野:
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) is an orally active potassium-lowering agent. Calcium polystyrene sulfonate binds potassium in the distal colon in exchange for Ca 2+. Calcium polystyrene sulfonate can be used for the research of hyperkalemia in chronic kidney disease .
Target:
製品番号: HY-121826
CAS 番号: 860174-12-5
別名: ATI-7505
Target:
Naronapride (ATI-7505) is a potent prokinetic 5-HT4 receptor agonist. Naronapride can be used for gastrointestinal diseases research .
製品番号: HY-B0680
CAS 番号: 333963-40-9
別名: RU-0211 (hemiketal); SPI-0211 (hemiketal)
Target:
Lubiprostone (hemiketal) (RU-0211 (hemiketal)) is a selective chloride channel 2 (CLCN2) activator. Lubiprostone (hemiketal) is used to treat chronic idiopathic constipation and opioid-induced constipation by activating CLCN2 channels to increase chloride ion secretion in the intestine, thereby increasing intestinal fluid secretion and enhancing intestinal peristalsis. Lubiprostone (hemiketal) can be used in the study of chronic constipation and cancer .
製品番号: HY-17584R
CAS 番号: 851199-59-2
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研究分野:
製品番号: HY-15790H
CAS 番号: 439087-68-0
別名: (S)-A 3309; (S)-AZD 7806
(S)-Elobixibat is the S enantiomer of Elobixibat (HY-15790). (S)-Elobixibat is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor. (S)-Elobixibat decreases LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to study metabolic syndrome. (S)-Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors .
製品番号: HY-12694R
CAS 番号: 179474-85-2
別名: R-108512 (Standard)
研究分野:
Prucalopride (succinate) (Standard) is the analytical standard of Prucalopride (succinate). This product is intended for research and analytical applications. Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer .
製品番号: HY-P11246
CAS 番号: 3057097-31-8
Target:
研究分野:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
