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Results for "

compatibility

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATP Synthase (1) Bacterial (1) Biochemical Assay Reagents (22) Cholinesterase (ChE) (1) COX (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Environmental Pollutants (4) Fluorescent Dye (3) Glycosidase (1) PD-1/PD-L1 (1) Polo-like Kinase (PLK) (1) Reference Standards (2)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W763806

Zein	Environmental Pollutants Biochemical Assay Reagents	Others
Zein is a plant protein‐based polymer, can be used to prepare nanofibrous mats through electrospun. Zein has good cell compatibility and easy fabrication ability, and can be used in drug delivery systems .

HY-B1937

Sodium dodecylbenzenesulfonate Bio-Soft S 101 sodium	Environmental Pollutants Biochemical Assay Reagents	Others
Sodium dodecylbenzenesulfonate (Bio-Soft S 101 sodium) is a nonionic surfactant commonly used in a variety of applications for cleaning and treating industrial equipment. It has good cleaning power and environmental compatibility, and can effectively remove oil, dirt and other forms of contamination. In addition, in textile, paper, leather and other industries, the compound can also be used for fixing and stabilizing dyes and colors. Although the compound has no direct application in the medical field, it plays an important role in industry and laboratory research.

HY-W099538

Dilauryl thiodipropionate Dilauryl 3,3'-Thiodipropionate	Environmental Pollutants Biochemical Assay Reagents	Others
Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.

HY-135737

Dicaprylyl carbonate 1 Publications Verification Dioctyl carbonate	Others	Others
Dicaprylyl carbonate, a solid, plant-derived fat, is a dry emollient. Dicaprylyl carbonate has excellent dermatological compatibility and a comprehensive performance profile, such as solubilizing and dispersing ability for sun-care filters .

HY-W145682

Blood group H disaccharide Blood Group H	Biochemical Assay Reagents	Others
Blood group H carbohydrate is a carbohydrate containing two monosaccharides, fucose and galactose, linked by α1-2 glycosidic bonds. It is the precursor of ABO blood group antigens, which are present on the surface of red blood cells and play a role in immune recognition and transfusion compatibility. Type H disaccharides have diverse applications in biochemical research, especially in the study of carbohydrate-protein interactions and the biosynthesis of blood group antigens. In addition, it can be used as a diagnostic tool to identify ABO blood group phenotypes.

HY-P10978

NK224	PD-1/PD-L1	Cancer
NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide ( ⁶⁸Ga and ¹⁸F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC₅₀ value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC) .

HY-W127740

α-Cetone Isomethyl-α-ionone; α-Isomethylionone	Environmental Pollutants Biochemical Assay Reagents	Others
Isonaline 70 is an industrial solvent that belongs to the family of high flash point aromatic naphtha solvents. It is commonly used in a variety of industries including paints and coatings, adhesives and rubber manufacturing, as a thinner and thinner for resins and polymers. Isonaline 70 has various properties that make it suitable for these applications, including its low viscosity, high solvency and good compatibility with other materials. In addition, it can also be used as a cleaning agent for mechanical equipment.

HY-D2215

Mito-CCY	Fluorescent Dye	Cancer
Mito-CCY is a mitochondria-targeted, NIR-absorbing cryptocyanine probe. Mito-CCY displays a high photothermal conversion efficiency, good biological compatibility in vitro, and photoinduced cytotoxicity in HeLa cells .

HY-167735

Salvizol Bisdequalinium diacetate	Bacterial	Infection
Salvizol (Bisdequalinium diacetate) is a chemotherapeutic agent with a broad spectrum of bactericidal activity, effective in the apical third of root canals. Salvizol possesses the ability to dissolve organic dentin matrix, facilitating mineralization and tubule exposure. Salvizol maintains a neutral pH, ensuring biological compatibility while exhibiting significant cleansing potency.

HY-E70601

DNA Recombinase	DNA/RNA Synthesis	Others
DNA Recombinase is a simple and efficient multi-segment recombinase mixture that can assemble single or multiple DNA fragments into a complete plasmid by recognizing the DNA insert and the homology arms (17bp-50bp) at the ends of the linearized vector, regardless of the length of the fragment or the end compatibility.

HY-W699792

R-(3)-Benzyloxymyristic acid methyl ester	Biochemical Assay Reagents
R-(3)-Benzyloxymyristic acid methyl ester is a nonpolar solvent with activity for studying lipid-related interactions. R-(3)-Benzyloxymyristic acid methyl ester can be used in scientific research to explore the properties and behavior of cell membranes. R-(3)-Benzyloxymyristic acid methyl ester exhibits excellent solubility and compatibility in biochemical experiments.

HY-15321A

Etoricoxib hydrochloride MK-0663 hydrochloride; L-791456 hydrochloride	COX	Inflammation/Immunology
Etoricoxib hydrochloride (MK-0663 hydrochloride) is a synthetic nonsteroidal anti-inflammatory drug with cyclooxygenase-2 inhibitory activity. Etoricoxib hydrochloride can inhibit the conversion of arachidonic acid to prostaglandins, thereby reducing inflammation and pain. Etoricoxib hydrochloride is used to inhibit osteoarthritis and has anti-inflammatory and bone remodeling effects. The formulation of etoricoxib hydrochloride is prepared by emulsion solvent evaporation technology and exhibits good cell compatibility and enhanced alkaline phosphatase activity .

HY-B1937R

Sodium dodecylbenzenesulfonate (Standard) Bio-Soft S 101 sodium (Standard)	Biochemical Assay Reagents Reference Standards	Others
Sodium dodecylbenzenesulfonate (Standard) is the analytical standard of Sodium dodecylbenzenesulfonate. This product is intended for research and analytical applications. Sodium dodecylbenzenesulfonate (Bio-Soft S 101 sodium) is a nonionic surfactant commonly used in a variety of applications for cleaning and treating industrial equipment. It has good cleaning power and environmental compatibility, and can effectively remove oil, dirt and other forms of contamination. In addition, in textile, paper, leather and other industries, the compound can also be used for fixing and stabilizing dyes and colors. Although the compound has no direct application in the medical field, it plays an important role in industry and laboratory research.

HY-W099538R

Dilauryl thiodipropionate (Standard) Dilauryl 3,3'-Thiodipropionate (Standard)	Biochemical Assay Reagents Reference Standards	Others
Dilauryl thiodipropionate (Standard) is the analytical standard of Dilauryl thiodipropionate. This product is intended for research and analytical applications. Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.

HY-W010902

Calcium fructose diphosphate Dicalcium 1,6-di-O-phosphonato-L-tagatose	Endogenous Metabolite ATP Synthase	Metabolic Disease
Calcium fructose diphosphate (Dicalcium 1,6-di-O-phosphonato-L-tagatose) is a crucial intermediate in the glycolysis process and is closely related to ATP synthesis. Calcium fructose diphosphate can be used to regulate calcium and phosphorus balance, protect myocardial tissue from ischemia/reperfusion injury, counteract the effects of alcohol, and serve as a safer source of phosphate in parenteral nutrition .

HY-123702

CAP-53194	Polo-like Kinase (PLK)	Cancer
CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing .

HY-168374B

DSPE-PEG5000-Mannose	Biochemical Assay Reagents	Others
DSPE-PEG5000-Mannose is a conjugate composed of DSPE, a PEG chain, and terminal mannose. DSPE-PEG5000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947C

DSG-PEG5000-Mannose	Biochemical Assay Reagents	Others
DSG-PEG5000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG5000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947A

DSG-PEG2000-Mannose	Biochemical Assay Reagents	Others
DSG-PEG2000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG2000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-168374D

DSPE-PEG10000-Mannose	Biochemical Assay Reagents	Others
DSPE-PEG10000-Mannose is a conjugate composed of DSPE, a PEG chain, and terminal mannose. DSPE-PEG10000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947D

DSG-PEG10000-Mannose	Biochemical Assay Reagents	Others
DSG-PEG10000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG10000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947B

DSG-PEG3400-Mannose	Biochemical Assay Reagents	Others
DSG-PEG3400-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG3400-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947

DSG-PEG1000-Mannose	Biochemical Assay Reagents	Others
DSG-PEG1000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG1000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-168374C

DSPE-PEG3400-Mannose	Biochemical Assay Reagents	Others
DSPE-PEG3400-Mannose is a conjugate composed of DSPE, a PEG chain, and terminal mannose. DSPE-PEG3400-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903D

DMG-PEG10000-Mannose	Biochemical Assay Reagents	Others
DMG-PEG10000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG10000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903C

DMG-PEG5000-Mannose	Biochemical Assay Reagents	Others
DMG-PEG5000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG5000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903B

DMG-PEG3400-Mannose	Biochemical Assay Reagents	Others
DMG-PEG3400-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG3400-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903A

DMG-PEG2000-Mannose	Biochemical Assay Reagents	Others
DMG-PEG2000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG2000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903

DMG-PEG1000-Mannose	Biochemical Assay Reagents	Others
DMG-PEG1000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG1000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182615

Cymserine	Cholinesterase (ChE)	Neurological Disease
Cymserine is a blood-brain barrier-permeable butyrylcholinesterase (BuChE) inhibitor with an IC₅₀ value of 56.43 nM and a K_i of 38 nM. Cymserine binds to the catalytic domain of BuChE in a concentration-dependent manner to form a stable carbamylated enzyme complex, and exhibits BuChE selectivity over acetylcholinesterase due to its structural compatibility with the larger acyl-binding pocket of BuChE. Cymserine can be used in the research of Alzheimer's disease .

HY-W002006

6-Amino-1,3-dimethyluracil	Biochemical Assay Reagents	Others
6-Amino-1,3-dimethyluracil is a 6-aminouracil derivative and also functions as an organic thermal stabilizer for polyvinyl chloride (PVC). Its compatibility with PVC is lower than that of Ca ²⁺/Zn ²⁺ stabilizers and alkyl-substituted bis(6-amino-1,3-dimethyluracil-5-yl)methane derivatives. 6-Amino-1,3-dimethyluracil can be used to prepare PVC films, which exhibit lower transparency compared to PVC films stabilized by its derived bis-uracil compounds .

HY-D3186

HMRef-βGal	Fluorescent Dye Glycosidase	Cancer
HMRef-βGal is a fluorescent probe and a substrate responsive to β-galactosidase (β-galactosidase) (Ex/Em=498 nm/505-600 nm). After being cleaved by β-galactosidase, HMRef-βGal triggers significant fluorescence enhancement via intramolecular spirocyclic function regulation. HMRef-βGal generates bright fluorescence in cancer cells with elevated β-galactosidase activity, enabling visualization of tiny peritoneal metastases in mouse models. HMRef-βGal exhibits low in vitro cytotoxicity and low acute in vivo toxicity in mice. HMRef-βGal can be used for preclinical fluorescence-guided diagnosis and cytoreductive surgery of peritoneal metastases, including compatibility with real-time naked-eye detection and endoscopic imaging, as well as for studies related to peritoneal metastases of ovarian cancer .

HY-D3210

DCM-KPV	Fluorescent Dye	Inflammation/Immunology
DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λ_ex=480 nm, λ_em=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group .

Cat. No.	Product Name

HY-E0077

Adhesive Aluminium Foil Plate Seal	0 compounds
MCE adhesive aluminium foil plate seals are of strong adhesive that can reduce chance of well-to-well contamination and sample evaporation when applied to microplates. This aluminium foil seal is suitable for long-term storage of samples at -80°C. The high integrity sealing materials give the best protection against evaporation and contamination. The aluminium foil seal features excellent chemical resistance to DMSO and DNase- & RNase- free. MCE adhesive foil seal is pierceable, peelable and easy-to-use.

Adhesive Aluminium Foil Plate Seal

0 compounds

MCE adhesive aluminium foil plate seals are of strong adhesive that can reduce chance of well-to-well contamination and sample evaporation when applied to microplates. This aluminium foil seal is suitable for long-term storage of samples at -80°C. The high integrity sealing materials give the best protection against evaporation and contamination. The aluminium foil seal features excellent chemical resistance to DMSO and DNase- & RNase- free. MCE adhesive foil seal is pierceable, peelable and easy-to-use.

HY-L221

Cosmetic Ingredient Compound Library	621 compounds
Cosmetics are complex mixtures formulated through the rational blending and processing of various natural, synthetic, or extracted raw materials. The ingredients used in cosmetics are diverse in type and functionality. Based on their properties and applications, cosmetic ingredients can generally be classified into two main categories: base materials and auxiliary ingredients. The former constitutes the primary component of cosmetics, accounting for a significant proportion in formulations and serving as the key functional substances. Auxiliary ingredients, on the other hand, play roles in shaping the product, ensuring stability, or imparting color, fragrance, and other specific characteristics.Establishing a systematic ingredient database is of great significance for cosmetic research and development. By analyzing the physicochemical properties (such as oil-water partition coefficients and molecular weight distribution), biological activity mechanisms (such as antioxidant pathways and cellular signaling regulation), and compatibility of ingredients, the database can provide precise guidance for formulation design. This approach helps shorten the development cycle of cosmetic/skincare products and reduces trial-and-error costs. MCE offers 621 types of cosmetic ingredient compounds, including antioxidants, humectants, emulsifiers, film-forming agents, and more.

Cosmetic Ingredient Compound Library

621 compounds

Cosmetics are complex mixtures formulated through the rational blending and processing of various natural, synthetic, or extracted raw materials. The ingredients used in cosmetics are diverse in type and functionality. Based on their properties and applications, cosmetic ingredients can generally be classified into two main categories: base materials and auxiliary ingredients. The former constitutes the primary component of cosmetics, accounting for a significant proportion in formulations and serving as the key functional substances. Auxiliary ingredients, on the other hand, play roles in shaping the product, ensuring stability, or imparting color, fragrance, and other specific characteristics.Establishing a systematic ingredient database is of great significance for cosmetic research and development. By analyzing the physicochemical properties (such as oil-water partition coefficients and molecular weight distribution), biological activity mechanisms (such as antioxidant pathways and cellular signaling regulation), and compatibility of ingredients, the database can provide precise guidance for formulation design. This approach helps shorten the development cycle of cosmetic/skincare products and reduces trial-and-error costs.

MCE offers 621 types of cosmetic ingredient compounds, including antioxidants, humectants, emulsifiers, film-forming agents, and more.

HY-L943

MCE‑18 Novelty drug‑like Library	37030 compounds
MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets. This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.

MCE‑18 Novelty drug‑like Library

37030 compounds

MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets.

This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.

HY-L945

Sulfonyl Fluoride Fragment Library	1162 compounds
Sulfonyl fluoride (-SO₂F) overcomes the bottleneck of target selectivity in traditional covalent warheads through its unique chemical and biological properties, which rely heavily on cysteine (Cys) residues. Featuring high stability and tunable electrophilicity under physiological conditions, it can target a wide range of nucleophilic residues including lysine (Lys), tyrosine (Tyr), serine (Ser), and histidine (His). It offers the advantages of a broader druggable space, lower off-target risks, and long-lasting efficacy, with numerous reported cases in the research of covalent inhibitors, Molecular glue, PROTACs, and chemical biology probe development. MCE constructs a highly diverse sulfonyl fluoride fragment library based on the reactivity, stability and physiological compatibility of sulfonyl fluoride. The library contains 1000 efficiently synthesized and stable sulfonyl fluoride fragments, which ensure precise reactivity of the warhead and retain sufficient derivatization space for subsequent optimization. Combined with the modular strategy of SuFEx click chemistry, it enables versatile modification of compounds and functionalization of complex molecules, improves the efficiency of structural optimization and rapidly expands druggability, making it suitable for high-throughput probe and custom covalent library construction. It provides an efficient research tool for the development of broad-spectrum covalent inhibitors targeting Lys/Tyr/Ser/His, covalent PROTACs for E3 ligases and chemical biology probe development, meeting the requirements of modern drug research for high throughput, high success rate and high derivatization potential. This library contains 1,162 sulfonyl fluoride fragments with high structural diversity, favorable drug-like properties and tunable electrophilicity. It is well suited for precise targeting of non-Cys residues and meets the criteria of simple structure and high derivatization potential. It effectively improves

Sulfonyl Fluoride Fragment Library

1162 compounds

Sulfonyl fluoride (-SO₂F) overcomes the bottleneck of target selectivity in traditional covalent warheads through its unique chemical and biological properties, which rely heavily on cysteine (Cys) residues. Featuring high stability and tunable electrophilicity under physiological conditions, it can target a wide range of nucleophilic residues including lysine (Lys), tyrosine (Tyr), serine (Ser), and histidine (His). It offers the advantages of a broader druggable space, lower off-target risks, and long-lasting efficacy, with numerous reported cases in the research of covalent inhibitors, Molecular glue, PROTACs, and chemical biology probe development.

MCE constructs a highly diverse sulfonyl fluoride fragment library based on the reactivity, stability and physiological compatibility of sulfonyl fluoride. The library contains 1000 efficiently synthesized and stable sulfonyl fluoride fragments, which ensure precise reactivity of the warhead and retain sufficient derivatization space for subsequent optimization. Combined with the modular strategy of SuFEx click chemistry, it enables versatile modification of compounds and functionalization of complex molecules, improves the efficiency of structural optimization and rapidly expands druggability, making it suitable for high-throughput probe and custom covalent library construction. It provides an efficient research tool for the development of broad-spectrum covalent inhibitors targeting Lys/Tyr/Ser/His, covalent PROTACs for E3 ligases and chemical biology probe development, meeting the requirements of modern drug research for high throughput, high success rate and high derivatization potential.

This library contains 1,162 sulfonyl fluoride fragments with high structural diversity, favorable drug-like properties and tunable electrophilicity. It is well suited for precise targeting of non-Cys residues and meets the criteria of simple structure and high derivatization potential. It effectively improves

Cat. No.	Product Name	Type

HY-D2215

Mito-CCY	Fluorescent Dye
Mito-CCY is a mitochondria-targeted, NIR-absorbing cryptocyanine probe. Mito-CCY displays a high photothermal conversion efficiency, good biological compatibility in vitro, and photoinduced cytotoxicity in HeLa cells .

HY-D3186

HMRef-βGal	Fluorescent Dye
HMRef-βGal is a fluorescent probe and a substrate responsive to β-galactosidase (β-galactosidase) (Ex/Em=498 nm/505-600 nm). After being cleaved by β-galactosidase, HMRef-βGal triggers significant fluorescence enhancement via intramolecular spirocyclic function regulation. HMRef-βGal generates bright fluorescence in cancer cells with elevated β-galactosidase activity, enabling visualization of tiny peritoneal metastases in mouse models. HMRef-βGal exhibits low in vitro cytotoxicity and low acute in vivo toxicity in mice. HMRef-βGal can be used for preclinical fluorescence-guided diagnosis and cytoreductive surgery of peritoneal metastases, including compatibility with real-time naked-eye detection and endoscopic imaging, as well as for studies related to peritoneal metastases of ovarian cancer .

HMRef-βGal

Fluorescent Dye

HMRef-βGal is a fluorescent probe and a substrate responsive to β-galactosidase (β-galactosidase) (Ex/Em=498 nm/505-600 nm). After being cleaved by β-galactosidase, HMRef-βGal triggers significant fluorescence enhancement via intramolecular spirocyclic function regulation. HMRef-βGal generates bright fluorescence in cancer cells with elevated β-galactosidase activity, enabling visualization of tiny peritoneal metastases in mouse models. HMRef-βGal exhibits low in vitro cytotoxicity and low acute in vivo toxicity in mice. HMRef-βGal can be used for preclinical fluorescence-guided diagnosis and cytoreductive surgery of peritoneal metastases, including compatibility with real-time naked-eye detection and endoscopic imaging, as well as for studies related to peritoneal metastases of ovarian cancer .

HY-D3210

DCM-KPV	Fluorescent Dye
DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λ_ex=480 nm, λ_em=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group .

DCM-KPV

Fluorescent Dye

DCM-KPV is a fluorescent probe targeting the human intestinal oligopeptide transporter PEPT1/SLC15A1 receptor (λ_ex=480 nm, λ_em=620-670 nm). DCM-KPV specifically binds to PepT1 via its KPV domain and mediates receptor-targeted internalization, thus effectively accumulating in the cytoplasm and nucleus of cells overexpressing this receptor. DCM-KPV has the advantages of long emission wavelength, high emission efficiency, low photobleaching, and negligible cytotoxicity. DCM-KPV maintains stable fluorescence intensity under continuous illumination, exhibiting extremely high live cell compatibility. DCM-KPV can specifically accumulate at colonic inflammatory sites through the intestinal mucosa, enabling direct non-invasive visual differentiation between chronic and acute ulcerative colitis groups and the normal group .

Cat. No.	Product Name	Type

HY-W763806

Zein	Biochemical Assay Reagents
Zein is a plant protein‐based polymer, can be used to prepare nanofibrous mats through electrospun. Zein has good cell compatibility and easy fabrication ability, and can be used in drug delivery systems .

HY-B1937

Sodium dodecylbenzenesulfonate Bio-Soft S 101 sodium	Biochemical Assay Reagents
Sodium dodecylbenzenesulfonate (Bio-Soft S 101 sodium) is a nonionic surfactant commonly used in a variety of applications for cleaning and treating industrial equipment. It has good cleaning power and environmental compatibility, and can effectively remove oil, dirt and other forms of contamination. In addition, in textile, paper, leather and other industries, the compound can also be used for fixing and stabilizing dyes and colors. Although the compound has no direct application in the medical field, it plays an important role in industry and laboratory research.

Sodium dodecylbenzenesulfonate

Bio-Soft S 101 sodium

Biochemical Assay Reagents

Sodium dodecylbenzenesulfonate (Bio-Soft S 101 sodium) is a nonionic surfactant commonly used in a variety of applications for cleaning and treating industrial equipment. It has good cleaning power and environmental compatibility, and can effectively remove oil, dirt and other forms of contamination. In addition, in textile, paper, leather and other industries, the compound can also be used for fixing and stabilizing dyes and colors. Although the compound has no direct application in the medical field, it plays an important role in industry and laboratory research.

HY-W099538

Dilauryl thiodipropionate Dilauryl 3,3'-Thiodipropionate	Biochemical Assay Reagents
Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.

Dilauryl thiodipropionate

Dilauryl 3,3'-Thiodipropionate

Biochemical Assay Reagents

Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.

HY-W145682

Blood group H disaccharide

Blood Group H

Biochemical Assay Reagents

Blood group H carbohydrate is a carbohydrate containing two monosaccharides, fucose and galactose, linked by α1-2 glycosidic bonds. It is the precursor of ABO blood group antigens, which are present on the surface of red blood cells and play a role in immune recognition and transfusion compatibility. Type H disaccharides have diverse applications in biochemical research, especially in the study of carbohydrate-protein interactions and the biosynthesis of blood group antigens. In addition, it can be used as a diagnostic tool to identify ABO blood group phenotypes.

HY-W127740

α-Cetone

Isomethyl-α-ionone; α-Isomethylionone

Biochemical Assay Reagents

Isonaline 70 is an industrial solvent that belongs to the family of high flash point aromatic naphtha solvents. It is commonly used in a variety of industries including paints and coatings, adhesives and rubber manufacturing, as a thinner and thinner for resins and polymers. Isonaline 70 has various properties that make it suitable for these applications, including its low viscosity, high solvency and good compatibility with other materials. In addition, it can also be used as a cleaning agent for mechanical equipment.

HY-W699792

R-(3)-Benzyloxymyristic acid methyl ester	Biochemical Assay Reagents
R-(3)-Benzyloxymyristic acid methyl ester is a nonpolar solvent with activity for studying lipid-related interactions. R-(3)-Benzyloxymyristic acid methyl ester can be used in scientific research to explore the properties and behavior of cell membranes. R-(3)-Benzyloxymyristic acid methyl ester exhibits excellent solubility and compatibility in biochemical experiments.

HY-B1937R

Sodium dodecylbenzenesulfonate (Standard)

Bio-Soft S 101 sodium (Standard)

Biochemical Assay Reagents

Sodium dodecylbenzenesulfonate (Standard) is the analytical standard of Sodium dodecylbenzenesulfonate. This product is intended for research and analytical applications. Sodium dodecylbenzenesulfonate (Bio-Soft S 101 sodium) is a nonionic surfactant commonly used in a variety of applications for cleaning and treating industrial equipment. It has good cleaning power and environmental compatibility, and can effectively remove oil, dirt and other forms of contamination. In addition, in textile, paper, leather and other industries, the compound can also be used for fixing and stabilizing dyes and colors. Although the compound has no direct application in the medical field, it plays an important role in industry and laboratory research.

HY-W099538R

Dilauryl thiodipropionate (Standard)

Dilauryl 3,3'-Thiodipropionate (Standard)

Biochemical Assay Reagents

Dilauryl thiodipropionate (Standard) is the analytical standard of Dilauryl thiodipropionate. This product is intended for research and analytical applications. Dilauryl thiodipropionate (DLTDP), which is a sulfur-containing antioxidant commonly used to stabilize polymers and plastics against degradation caused by heat, oxygen, and UV light, acts to scavenge free radicals and others that may cause polymer chain scission and cross-linked active substances, in addition, DLTDP has been used as an additive to lubricants, oils and other industrial fluids to improve their oxidation stability, the long hydrocarbon chain in DLTDP makes it low volatility and compatible with many materials and Good compatibility with substrates.

HY-168374B

DSPE-PEG5000-Mannose	Biochemical Assay Reagents
DSPE-PEG5000-Mannose is a conjugate composed of DSPE, a PEG chain, and terminal mannose. DSPE-PEG5000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947C

DSG-PEG5000-Mannose	Biochemical Assay Reagents
DSG-PEG5000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG5000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947A

DSG-PEG2000-Mannose	Biochemical Assay Reagents
DSG-PEG2000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG2000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-168374D

DSPE-PEG10000-Mannose	Biochemical Assay Reagents
DSPE-PEG10000-Mannose is a conjugate composed of DSPE, a PEG chain, and terminal mannose. DSPE-PEG10000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947D

DSG-PEG10000-Mannose	Biochemical Assay Reagents
DSG-PEG10000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG10000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947B

DSG-PEG3400-Mannose	Biochemical Assay Reagents
DSG-PEG3400-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG3400-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182947

DSG-PEG1000-Mannose	Biochemical Assay Reagents
DSG-PEG1000-Mannose is a conjugate composed of DSG, a PEG chain, and terminal mannose. DSG-PEG1000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-168374C

DSPE-PEG3400-Mannose	Biochemical Assay Reagents
DSPE-PEG3400-Mannose is a conjugate composed of DSPE, a PEG chain, and terminal mannose. DSPE-PEG3400-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903D

DMG-PEG10000-Mannose	Biochemical Assay Reagents
DMG-PEG10000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG10000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903C

DMG-PEG5000-Mannose	Biochemical Assay Reagents
DMG-PEG5000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG5000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903B

DMG-PEG3400-Mannose	Biochemical Assay Reagents
DMG-PEG3400-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG3400-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903A

DMG-PEG2000-Mannose	Biochemical Assay Reagents
DMG-PEG2000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG2000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

HY-182903

DMG-PEG1000-Mannose	Biochemical Assay Reagents
DMG-PEG1000-Mannose is a conjugate composed of dimyristoylglycerol (DMG), a PEG chain, and terminal mannose. DMG-PEG1000-Mannose combines the membrane compatibility of phospholipids with the targeted recognition capabilities of mannose, making it suitable for research in biomaterial construction and drug delivery.

Cat. No.	Product Name	Target	Research Area

HY-P10978

NK224	PD-1/PD-L1	Cancer
NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide ( ⁶⁸Ga and ¹⁸F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC₅₀ value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-135737

Dicaprylyl carbonate 1 Publications Verification Dioctyl carbonate	Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Others
Dicaprylyl carbonate, a solid, plant-derived fat, is a dry emollient. Dicaprylyl carbonate has excellent dermatological compatibility and a comprehensive performance profile, such as solubilizing and dispersing ability for sun-care filters .

HY-W145682

Blood group H disaccharide Blood Group H	Structural Classification Polysaccharides Endogenous metabolite Saccharides	Biochemical Assay Reagents
Blood group H carbohydrate is a carbohydrate containing two monosaccharides, fucose and galactose, linked by α1-2 glycosidic bonds. It is the precursor of ABO blood group antigens, which are present on the surface of red blood cells and play a role in immune recognition and transfusion compatibility. Type H disaccharides have diverse applications in biochemical research, especially in the study of carbohydrate-protein interactions and the biosynthesis of blood group antigens. In addition, it can be used as a diagnostic tool to identify ABO blood group phenotypes.

HY-W127740

α-Cetone Isomethyl-α-ionone; α-Isomethylionone	Source Classification	Environmental Pollutants Biochemical Assay Reagents
Isonaline 70 is an industrial solvent that belongs to the family of high flash point aromatic naphtha solvents. It is commonly used in a variety of industries including paints and coatings, adhesives and rubber manufacturing, as a thinner and thinner for resins and polymers. Isonaline 70 has various properties that make it suitable for these applications, including its low viscosity, high solvency and good compatibility with other materials. In addition, it can also be used as a cleaning agent for mechanical equipment.

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