Search Result

Results for "

desaturase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dihydroceramide Desaturase 1 (DES1) (4) Stearoyl-CoA Desaturase (SCD) (34) Acetolactate Synthase (ALS) (1) Apoptosis (6) Autophagy (1) Bacterial (5) Biochemical Assay Reagents (3) Calcium Channel (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Intermediate (1) Endogenous Metabolite (4) Environmental Pollutants (2) Eukaryotic Initiation Factor (eIF) (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (1) Fungal (2) Glutathione Peroxidase (1) Herbicide (6) Influenza Virus (3) Interleukin Related (1) Isotope-Labeled Compounds (4) LDLR (1) Lipoxygenase (1) MNK (1) mTOR (1) p38 MAPK (1) PGE synthase (1) PI3K (1) PPAR (1) Reactive Oxygen Species (ROS) (5) Reference Standards (7) SOD (1) Src (2) STAT (2) TNF Receptor (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Infection (7) Inflammation/Immunology (9) Metabolic Disease (21) Neurological Disease (8)

By Targets:

Dihydroceramide Desaturase 1 (DES1) (4)

Stearoyl-CoA Desaturase (SCD) (34)

Acetolactate Synthase (ALS) (1)

Apoptosis (6)

Autophagy (1)

Bacterial (5)

Biochemical Assay Reagents (3)

Calcium Channel (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Drug Intermediate (1)

Endogenous Metabolite (4)

Environmental Pollutants (2)

Eukaryotic Initiation Factor (eIF) (1)

Fatty Acid Synthase (FASN) (2)

Ferroptosis (1)

Fungal (2)

Glutathione Peroxidase (1)

Herbicide (6)

Influenza Virus (3)

Interleukin Related (1)

Isotope-Labeled Compounds (4)

LDLR (1)

Lipoxygenase (1)

MNK (1)

mTOR (1)

p38 MAPK (1)

PGE synthase (1)

PI3K (1)

PPAR (1)

Reactive Oxygen Species (ROS) (5)

Reference Standards (7)

SOD (1)

Src (2)

STAT (2)

TNF Receptor (1)

By Research Areas:

Cancer (15)

Cardiovascular Disease (1)

Infection (7)

Inflammation/Immunology (9)

Metabolic Disease (21)

Neurological Disease (8)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Dihydroceramide Desaturase 1 (DES1) Stearoyl-CoA Desaturase (SCD)

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-50709

A939572 Maximum Cited Publications 40 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Cancer
A939572 is a potent, and orally bioavailable *stearoyl-CoA desaturase1 (SCD1)* inhibitor with IC₅₀ values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.

HY-107410

SC-26196 4 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties .

HY-N0121

Sesamin Maximum Cited Publications 11 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Neurological Disease
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-15823

CAY10566 15+ Cited Publications	Stearoyl-CoA Desaturase (SCD)	Cancer
CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC₅₀s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. CAY10566 also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC₅₀=7.9 nM or 6.8 nM) .

HY-15700

PluriSIn 1 4 Publications Verification NSC 14613	Stearoyl-CoA Desaturase (SCD) Apoptosis	Cancer
PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor.

HY-155033

SSI-4	Stearoyl-CoA Desaturase (SCD) DNA/RNA Synthesis Apoptosis Autophagy mTOR Influenza Virus	Metabolic Disease Inflammation/Immunology Cancer
SSI-4 is an orally active stearoyl-CoA desaturase (SCD1) inhibitor with an EC₅₀ of 1.9 nM against mouse SCD1. SSI-4 blocks the conversion of saturated fatty acids to monounsaturated fatty acids, reducing the production of oleic acid and palmitoleic acid. SSI-4 induces lipid peroxidation, endoplasmic reticulum stress, DNA damage and activates apoptotic mechanisms. SSI-4 inhibits mTORC1 activity, suppresses B cell proliferation and antibody production, and induces autophagy. SSI-4 is applicable to research on cancers such as acute myeloid leukemia and renal cell carcinoma, as well as influenza infections .

HY-19762

GSK1940029 3 Publications Verification SCD inhibitor 1	Stearoyl-CoA Desaturase (SCD)	Cancer
GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16.

HY-13070

MK-8245 4 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MK-8245 is a potent, liver-targeted *stearoyl-CoA desaturase* (SCD) inhibitor, with IC₅₀**s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy .

HY-127143

Sterculic acid	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC₅₀ value of 0.9 μM .

HY-N6807

Elemicin 1 Publications Verification	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial	Infection Cancer
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits *Stearoyl-CoA Desaturase* 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral** activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-15822

MF-438 5+ Cited Publications	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MF-438 is a potent and orally bioavailable *stearoyl-CoA desaturase* 1 (SCD1) inhibitor with an IC₅₀** of 2.3 nM for rSCD1 .

HY-N0701

(-)-Asarinin 1 Publications Verification	Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
(-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive *Δ5-desaturase* inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects .

HY-115319

CP-24879 hydrochloride 2 Publications Verification	Ferroptosis	Inflammation/Immunology
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research .

HY-117427

D5D-IN-326 2 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
D5D-IN-326 is a selective, orally active *delta-5 desaturase* (D5D) inhibitor, with IC₅₀**s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice .

HY-141525

SCD1 inhibitor-4	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
SCD1 inhibitor-4 is a potent, orally active stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes .

HY-124346

T-3364366 1 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC₅₀s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC₅₀0=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC₅₀=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,₅₀ >10000 nM) in the enzymatic activity assay .

HY-163472

PR280	Dihydroceramide Desaturase 1 (DES1)	Neurological Disease Metabolic Disease Cancer
PR280 is a *dihydroceramide desaturase* 1 (Des1) inhibitor with an IC₅₀** of 700 nM. PR280 is used for the research of metabolic diseases, cancers, and neurodegenerative diseases .

HY-W040206

Diflufenican	Environmental Pollutants Acetolactate Synthase (ALS) Herbicide	Others
Diflufenican is a Herbicide. Diflufenican inhibits phytoene desaturase (PDS) in the carotenoid synthesis pathway. Diflufenican suppresses the production of PDS, blocks carotenoid biosynthesis, thereby inducing chlorophyll destruction and cell membrane rupture, and ultimately causes the death of broadleaf weeds. The combination of Diflufenican and Flufenacet can be used to control Lolium rigidum populations resistant to ALS/ACCase .

HY-141469

6,9,12,15,18-Heneicosapentaenoic acid HPA; Heneicosapentaenoic acid methyl ester	PGE synthase Lipoxygenase	Cardiovascular Disease Neurological Disease
6,9,12,15,18-Heneicosapentaenoic acid (HPA) is a ∆5 desaturase inhibitor. 6,9,12,15,18-Heneicosapentaenoic acid serves as a weak substrate for Prostaglandin H synthase and 5-lipoxygenase, yet it inactivates Prostaglandin H synthase at a rate comparable to that of AA, EPA and DHA. 6,9,12,15,18-Heneicosapentaenoic acid is a weak inducer of Aacyl-CoA oxidase. 6,9,12,15,18-Heneicosapentaenoic acid incorporates into phospholipids and triacylglycerols in cell culture. 6,9,12,15,18-Heneicosapentaenoic acid can be used in research related to liver cancer .

HY-N7864

Osbond acid all-cis-4,7,10,13,16-Docosapentaenoic acid	Biochemical Assay Reagents	Others
Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

HY-114849

Norflurazon SAN 9789	Environmental Pollutants Herbicide	Others
Norflurazon (SAN 9789) is a bleaching herbicide. Norflurazon can block carotenoid biosynthesis by inhibiting phytoene desaturase activity .

HY-112812

SCD1 inhibitor-1	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC₅₀ of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity .

HY-135818

XM462	Dihydroceramide Desaturase 1 (DES1)	Cancer
XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (K_i=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC₅₀ values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor .

HY-N0121A

(-)-Sesamin	Others	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

HY-134423S

Stearoyl coenzyme A-13C18 lithium	Isotope-Labeled Compounds	Others
Stearoyl coenzyme A- ¹³C₁₈ (lithium) is the ¹³C labeled Stearoyl coenzyme A lithium . Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .

HY-34054

2,4-Dichloro-5-nitropyridine	Drug Intermediate	Others
2,4-Dichloro-5-nitropyridine is a pyridine derivative, which can be used as a precursor to synthesize polyfluorinated pyrrolidine derivatives ^[3][4].

HY-151095

*Phytoene desaturase-IN-1*	Reactive Oxygen Species (ROS)	Others
Phytoene desaturase-IN-1 is a potent *phytoene desaturase* (PDS) inhibitor (K_d*: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase*-IN-1 can be used in the area of agricultural production .

HY-102045

T-3764518	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC₅₀ of 4.7 nM.

HY-100249

XEN723	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC₅₀s of 45 and 524 nM in mouse and HepG2 cell, respectively.

HY-124084

SW203668	Stearoyl-CoA Desaturase (SCD)	Cancer
SW203668 is an irreversible *stearoyl CoA desaturase* (SCD) inhibitor with an IC₅₀** of 54 nM. SW203668 covalently binds and inhibits SCD, depletes unsaturated fatty acids, and triggers cell death in sensitive cells. SW203668 requires demethylation by CYP4F11 to form its active SCD-inhibiting form; differential CYP4F11 expression drives selective cytotoxicity. SW203668 exerts cytotoxicity toward CYP4F11-expressing non-small cell lung cancer (NSCLC) cells and spares CYP4F11-lacking NSCLC cells. SW203668 inhibits tumor growth in immunodeficient mice bearing CYP4F11-expressing NSCLC xenografts and spares mouse skin sebocytes. SW203668 can be used for the research of non-small cell lung cancer .

HY-13077

MK-8245 Trifluoroacetate 4 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.

HY-130703

5-Dehydroepisterol	Fungal	Infection
5-Dehydroepisterol is an episterol derivative and an intermediate in steroid biosynthesis. 5-Dehydroepisterol can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase. 5-Dehydroepisterol has anti-fungal activities .

HY-E70265

18:0 Coenzyme A triammonium	Fatty Acid Synthase (FASN) Endogenous Metabolite	Metabolic Disease
18:0 Coenzyme A (triammonium) is a preferred substrate of stearoyl-CoA desaturases (SCDs) .

HY-11034

CVT-12012	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC₅₀s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.

HY-124751

YTX-465	Stearoyl-CoA Desaturase (SCD)	Neurological Disease
YTX-465 is a *stearoyl-CoA desaturase* (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC₅₀**s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies .

HY-176274

FASN/SCD-IN-1	Fatty Acid Synthase (FASN) Stearoyl-CoA Desaturase (SCD) Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor SOD LDLR Glutathione Peroxidase	Metabolic Disease Inflammation/Immunology
FASN/SCD-IN-1 is a Silybin (HY-N0779A) derivative, an orally active inhibitor of Fatty Acid Synthase (FASN)/Stearoyl-CoA Desaturase (SCD). FASN/SCD-IN-1 has shown in vitro activity in inhibiting lipid deposition, reducing FASN and SCD transcriptional levels, and exhibiting antioxidant, anti-inflammatory, and anti-fibrotic activities. FASN/SCD-IN-1 has demonstrated significant hepatoprotective effects in a rat model of acute liver injury. FASN/SCD-IN-1 ameliorates the pathological features of MASH liver, including steatosis, inflammation, and fibrosis in a mouse model of myeloproliferative steatohepatitis (MASH). FASN/SCD-IN-1 can be used to study MASH .

HY-W673679

(1R,2S)-Deoxy-PR280	Dihydroceramide Desaturase 1 (DES1)	Others
(1R,2S)-Deoxy-PR280 is a competitive inhibitor of dihydroceramide desaturase, with a K_i of 6 µM .

HY-N0121R

Sesamin (Standard)	Stearoyl-CoA Desaturase (SCD) Reference Standards	Neurological Disease
Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N6807R

Elemicin (Standard)	Reference Standards Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial	Infection Cancer
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-157024

*Phytoene desaturase-IN-2*	Herbicide	Others
PDS-IN-1 is a potent inhibitor of Oryza sativa phytoene desaturase (OsPDS), resulting in herbicidal activity .

HY-50709R

A939572 (Standard)	Stearoyl-CoA Desaturase (SCD)	Cancer
A939572 (Standard) is the analytical standard of A939572. This product is intended for research and analytical applications. A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.

HY-124084A

SW203668 TFA	Stearoyl-CoA Desaturase (SCD)	Cancer
SW203668 TFA is an irreversible *stearoyl CoA desaturase* (SCD) inhibitor with an IC₅₀** of 54 nM. SW203668 TFA covalently binds and inhibits SCD, depletes unsaturated fatty acids, and triggers cell death in sensitive cells. SW203668 TFA requires demethylation by CYP4F11 to form its active SCD-inhibiting form; differential CYP4F11 expression drives selective cytotoxicity. SW203668 TFA exerts cytotoxicity toward CYP4F11-expressing non-small cell lung cancer (NSCLC) cells and spares CYP4F11-lacking NSCLC cells. SW203668 TFA inhibits tumor growth in immunodeficient mice bearing CYP4F11-expressing NSCLC xenografts and spares mouse skin sebocytes. SW203668 TFA can be used for the research of non-small cell lung cancer .

HY-W711035

Picolinafen AC 900001	p38 MAPK PI3K Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Cytochrome P450	Inflammation/Immunology
Picolinafen is a pyridine-class herbicide that acts as a phytoene desaturase (PDS) inhibitor. Picolinafen effectively controls broadleaf weeds and disrupts carotenoid biosynthesis. Picolinafen exhibits cytotoxicity to porcine trophectoderm (pTr) and luminal epithelial (pLE) cells. Picolinafen induces (ROS accumulation, calcium depletion, and activates (MAPK and PI3K signaling pathways, leading to decreased cell viability, increased apoptosis, impaired migration, and altered expression of implantation-related genes. Picolinafen has an LD₅₀ value of 2.7 mg/kg in mammals and 7 μg/L in fish. Picolinafen exhibits toxic effects during zebrafish embryogenesis ^[1][2].

HY-141635

cis-11,14-Eicosadienoic acid methyl ester	Endogenous Metabolite	Metabolic Disease
cis-11,14-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki=3.1 μM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki=3.0 μM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.

HY-134423

Stearoyl coenzyme A lithium Stearoyl-CoA lithium	Biochemical Assay Reagents	Others
Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .

HY-145437

N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide	Fungal	Infection
N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor and antifungal agent .

HY-114849R

Norflurazon (Standard) SAN 9789 (Standard)	Herbicide Reference Standards	Others
Norflurazon (Standard) is the analytical standard of Norflurazon. This product is intended for research and analytical applications. Norflurazon (SAN 9789) is a bleaching herbicide. Norflurazon can block carotenoid biosynthesis by inhibiting phytoene desaturase activity .

HY-N0121S

Sesamin-d8	Isotope-Labeled Compounds	Neurological Disease
Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-114527

TPMP-I-2	Apoptosis Stearoyl-CoA Desaturase (SCD)	Cancer
TPMP-I-2 is an anticancer agent that induces cancer cell lines Apoptosis and decreases protein levels of stearoyl-CoA desaturase. TPMP-I-2 prolongs the survival time of nude rats in a simulated micrometastatic cervical cancer model and reduces tumor growth in a breast cancer model in nude mice combined with immunotoxins .

HY-137411

(E/Z)-Linoleoyl-CoA (E/Z)-Linoleoyl Coenzyme A; (E/Z)-9,12-Octadecadienoyl Coenzyme A	Endogenous Metabolite	Others
(E/Z)-Linoleoyl-CoA is a substrate used to study the specificity and kinetics of acyl-CoA. (E/Z)-Linoleoyl-CoA has the ability to replace substrates, and its specificity can be changed by amino acid substitution, thereby affecting the reaction with different desaturases. The study of (E/Z)-Linoleoyl-CoA helps to understand the substrate specificity of mammalian front-end fatty acid desaturases and provides support for the efficient production of value-added fatty acids .

Cat. No.	상품명

HY-L087

Anti-Obesity Compound Library

3,558 compounds

Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries.

MCE Anti-Obesity Compound Library owns a unique collection of 3,558 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Cat. No.	상품명	Type

HY-N7864

Osbond acid

all-cis-4,7,10,13,16-Docosapentaenoic acid

Biochemical Assay Reagents

Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

HY-34054

2,4-Dichloro-5-nitropyridine	Biochemical Assay Reagents
2,4-Dichloro-5-nitropyridine is a pyridine derivative, which can be used as a precursor to synthesize polyfluorinated pyrrolidine derivatives ^[3][4].

HY-134423

Stearoyl coenzyme A lithium Stearoyl-CoA lithium	Biochemical Assay Reagents
Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-N0121

Sesamin Maximum Cited Publications 11 Publications Verification	Neurological Disease Classification of Application Fields Anti-aging Sesamum indicum Linn. Lignans Phenylpropanoids Pedaliaceae Plants Disease Research Fields Source Classification	Stearoyl-CoA Desaturase (SCD)
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-127143

Sterculic acid	Classification of Application Fields Ketones, Aldehydes, Acids Sterculiaceae Plants Inflammation/Immunology Disease Research Fields Sterculia foetida Linn. Source Classification	Stearoyl-CoA Desaturase (SCD)
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC₅₀ value of 0.9 μM .

HY-N6807

Elemicin 1 Publications Verification	Infection Asarum sieboldii Miq. Classification of Application Fields Simple Phenylpropanols Phenylpropanoids Plants Disease Research Fields Aristolochiaceae Source Classification	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits *Stearoyl-CoA Desaturase* 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral** activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N0701

(-)-Asarinin 1 Publications Verification	Asarum sieboldii Miq. Classification of Application Fields Lignans Phenylpropanoids Plants Aristolochiaceae Disease Research Fields Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial
(-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive *Δ5-desaturase* inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects .

HY-141469

6,9,12,15,18-Heneicosapentaenoic acid HPA; Heneicosapentaenoic acid methyl ester	Structural Classification Animals Lipid Source Classification	PGE synthase Lipoxygenase
6,9,12,15,18-Heneicosapentaenoic acid (HPA) is a ∆5 desaturase inhibitor. 6,9,12,15,18-Heneicosapentaenoic acid serves as a weak substrate for Prostaglandin H synthase and 5-lipoxygenase, yet it inactivates Prostaglandin H synthase at a rate comparable to that of AA, EPA and DHA. 6,9,12,15,18-Heneicosapentaenoic acid is a weak inducer of Aacyl-CoA oxidase. 6,9,12,15,18-Heneicosapentaenoic acid incorporates into phospholipids and triacylglycerols in cell culture. 6,9,12,15,18-Heneicosapentaenoic acid can be used in research related to liver cancer .

HY-N0121A

(-)-Sesamin	Classification of Application Fields Asarum forbesii Maxim. Lignans Other Diseases Phenylpropanoids Plants Disease Research Fields Aristolochiaceae Source Classification	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

HY-N0121R

Sesamin (Standard)	Structural Classification Sesamum indicum Linn. Lignans Phenylpropanoids Pedaliaceae Plants Source Classification	Stearoyl-CoA Desaturase (SCD) Reference Standards
Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N6807R

Elemicin (Standard)	Asarum sieboldii Miq. Structural Classification Simple Phenylpropanols Phenylpropanoids Plants Aristolochiaceae Source Classification	Reference Standards Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N0701R

(-)-Asarinin (Standard)	Asarum sieboldii Miq. Structural Classification Lignans Phenylpropanoids Plants Aristolochiaceae Source Classification	Reference Standards Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial
(-)-Asarinin (Standard) is the analytical standard of (-)-Asarinin (HY-N0701). This product is intended for research and analytical applications. (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive *Δ5-desaturase* inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects.

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HY-P702428

	SCD Protein, Human (Cell-Free, His) Stearoyl-CoA desaturase; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Fatty acid desaturase; FADS5; SCD1; SCDOS	Human	E. coli Cell-free
	SCD proteins (or stearoyl-CoA desaturases) critically catalyze the introduction of the first double bond into saturated fatty acyl-CoA substrates (such as palmitoyl-CoA and stearoyl-CoA). This process produces a mixture of 16:1 and 18:1 unsaturated fatty acids, which play a crucial role in lipid biosynthesis. SCD Protein, Human (Cell-Free, His) is the recombinant human-derived SCD protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SCD Protein, Human (Cell-Free, His) is 359 a.a., with molecular weight of 44.3 kDa.

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HY-134423S

Stearoyl coenzyme A-13C18 lithium
Stearoyl coenzyme A- ¹³C₁₈ (lithium) is the ¹³C labeled Stearoyl coenzyme A lithium . Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .

HY-N0121S

Sesamin-d8
Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-W778236

Norflurazon-13C,d3
Norflurazon- ¹³C,d₃ (SAN 9789- ¹³C,d₃) is the deuterium and ¹³C-labeled Norflurazon (HY-114849). Norflurazon (SAN 9789) is a bleaching herbicide. Norflurazon can block carotenoid biosynthesis by inhibiting phytoene desaturase activity .

HY-W013627S

trans,trans-2,4-Decadienal-d4
trans,trans-2,4-Decadienal-d₄ is deuterated labeled trans,trans-2,4-Decadienal (HY-W013627). trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid .

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