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D5D-IN-326 

Cat. No.: HY-117427
Handling Instructions

D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC50s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice.

For research use only. We do not sell to patients.

D5D-IN-326 Chemical Structure

D5D-IN-326 Chemical Structure

CAS No. : 1236767-85-3

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Description

D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC50s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice[1].

IC50 & Target

IC50: 72 nM (Rat D5D), 22 nM (Human D5D)[1]

In Vitro

D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC50s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity[1].

In Vivo

D5D-IN-326 (0.1, 1, and 10 mg/kg, p.o. for 6 weeks) gradually decreases body weight at 10 mg/kg, but lowers doses are not effective in DIO mice after treatment for 6 weeks[1].
D5D-IN-326 (10 mg/kg, p.o. for 6 weeks) also significantly decreases gene expression levels of Ccl2, Cd68, Adgre1, and Il6, decreases epididymal Lep and Adipoq mRNAs which are significantly increased in HFD DIO mice[1].

Molecular Weight

473.27

Formula

C₁₇H₁₁F₈N₃O₄

CAS No.

1236767-85-3

SMILES

O=C1C2=C(N=C(N1C3=CC=C(C=C3)OCC(F)(F)F)OCC(F)(C(F)(F)F)F)NC(C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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D5D-IN-326
Cat. No.:
HY-117427
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