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Results for "

duodenum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Akt (2) Apoptosis (2) Bacterial (5) Calcium Channel (5) Caspase (1) Cholecystokinin Receptor (4) Cholinesterase (ChE) (2) CXCR (1) Drug Derivative (5) Drug Metabolite (7) Elastase (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (1) Histamine Receptor (15) Isotope-Labeled Compounds (2) mAChR (5) Motilin Receptor (2) mRNA (1) Na+/K+ ATPase (2) Neurokinin Receptor (2) Neuropeptide Y Receptor (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) Phosphodiesterase (PDE) (1) PI3K (2) Potassium Channel (1) Prostaglandin Receptor (1) Proton Pump (4) Reference Standards (11) Secretin Receptor (2) Sigma Receptor (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (7) Endocrinology (10) Infection (5) Inflammation/Immunology (27) Metabolic Disease (20) Neurological Disease (7)
Oligonucleotides:	Transcription Factors (1) mRNA (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0093

Sincalide 4 Publications Verification Cholecystokinin octapeptide; CCK-8; SQ19844	Cholecystokinin Receptor Apoptosis PI3K Akt	Infection Cancer
Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-14289

Cimetidine Maximum Cited Publications 6 Publications Verification SKF-92334	Histamine Receptor Bacterial	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Cancer
Cimetidine (SKF-92334) is an orally active, inverse and BBB-permeable histamine H2 receptor antagonist with a K_i of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity .

HY-B2191

Sodium gualenate Guaiazulenesulfonate sodium	Drug Derivative	Inflammation/Immunology
Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.

HY-P0093A

Sincalide ammonium 4 Publications Verification Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium	Cholecystokinin Receptor Apoptosis PI3K Akt	Infection Cancer
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-P11292

Caloxin 1b3	Calcium Channel	Cardiovascular Disease
Caloxin 1b3, a peptide, is a selective plasma membrane Ca ²⁺ pump 1 (PMCA1) inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca ²⁺–Mg ²⁺-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca ²⁺ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research .

HY-B0305A

Roxatidine Acetate Hydrochloride HOE 760	Histamine Receptor	Metabolic Disease Inflammation/Immunology Cancer
Roxatidine Acetate Hydrochloride is a potent, selective, competitive and orally active histamine _H2-receptor antagonist. Roxatidine Acetate Hydrochloride has antisecretory potency against gastric acid secretion. Roxatidine Acetate Hydrochloride can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine Acetate Hydrochloride has antitumor activity .

HY-108278

Zolimidine	Drug Derivative	Endocrinology
Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research .

HY-109538

Secretin (swine)	Secretin Receptor	Neurological Disease Metabolic Disease
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism .

HY-B2191R

Sodium gualenate (Standard) Guaiazulenesulfonate sodium (Standard)	Drug Derivative Reference Standards	Inflammation/Immunology
Sodium gualenate (Standard) is the analytical standard of Sodium gualenate. This product is intended for research and analytical applications. Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.

HY-W008614

Lansoprazole sulfone 1 Publications Verification AG-1813	Drug Metabolite Proton Pump	Metabolic Disease
Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H ⁺, K ⁺-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H ⁺, K ⁺-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-14289R

Cimetidine (Standard) SKF-92334 (Standard)	Reference Standards Histamine Receptor Bacterial	Endocrinology Cancer
Cimetidine (Standard) is the analytical standard of Cimetidine. This product is intended for research and analytical applications. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity .

HY-137941

Roxatidine	Histamine Receptor Caspase NF-κB p38 MAPK	Inflammation/Immunology
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers .

HY-B1719A

Oxyphenonium bromide	mAChR	Inflammation/Immunology
Oxyphenonium bromide is an antiacetylcholine compound. Oxyphenonium bromide is an antagonist of mAChR. Oxyphenonium bromide protects against the bronchial obstructive effects .

HY-108283

Trepibutone AA 149; Supacal	Calcium Channel	Inflammation/Immunology
Trepibutone (AA 149) increases secretion of bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract. Trepibutone can be used for the research of cholecystitis and functional gastrointestinal disorders .

HY-B1109R

N-Acetylprocainamide (Standard) Acecainide (Standard); NAPA (Standard)	Reference Standards Potassium Channel Drug Metabolite	Cardiovascular Disease
Cimetidine (hydrochloride) (Standard) is the analytical standard of Cimetidine (hydrochloride). This product is intended for research and analytical applications. Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity .

HY-106327

EM-523	Motilin Receptor	Metabolic Disease
EM-523 is a motilin agonist and an erythromycin derivative. EM-523 has pED₅₀ values of 8.19 and 6.08 for promoting contractions in rabbit small intestinal tissue and human duodenal tissue, respectively. EM-523 can be used in the research of gastrointestinal diseases .

HY-W983015

Davidigenin	5-HT Receptor	Metabolic Disease
Davidigenin is an antidiabetic compound with antitumor, antispasmodic, and antioxidant activities. Davidigenin inhibits duodenal contractions induced by acetylcholine or histamine.

HY-123819

KRH-1636	CXCR	Infection
KRH-1636 is a CXC chemokine receptor (CXCR) 4 antagonist. KRH-1636 can be used in HIV-1 research .

HY-19105A

IT 066 hydrochloride	Histamine Receptor	Inflammation/Immunology
IT 066 hydrochloride is a Histamine H₂ receptor antagonist. IT 066 hydrochloride possesses antioxidant activity and can protect rats against acute gastric mucosal injury induced by ischemia-reperfusion. IT 066 hydrochloride can also inhibit secretagogue-induced gastric acid secretion in rats and exert a long-acting anti-lesion effect on experimental gastric and duodenal lesions in rats. IT 066 hydrochloride is applicable for the research of gastrointestinal diseases .

HY-19290

S-0509	Cholecystokinin Receptor	Others
S-0509 is a selective CCKB/gastrin receptor antagonist. S-0509 has a strong anti-secretion effect. S-0509 helps prevent the occurrence of duodenal ulcers .

HY-108171A

Hexocyclium methylsulfate	mAChR	Inflammation/Immunology
Hexocyclium methylsulfate is a potent mAChR antagonist with pK_i values of 8.9, 7.7, 8.4, 8.8 for M1, M2, M3, and M4 subtype, respectively. Hexocyclium methylsulfate has the potential for the research of duodenal ulcer and irritable bowel syndrome .

HY-106550

Enprostil RS 84135	Prostaglandin Receptor	Endocrinology
Enprostil (RS 84135) is a prostaglandin E2 derivative. Enprostil can inhibit amogastrin-stimulated gastric acid secretion, as well as reducing the secretion of pepsin. Enprostil can also serve as an antiulcer agent, used for research of duodenal or gastric ulcers .

HY-B2191A

Sodium gualenate hydrate Guaiazulenesulfonate sodium hydrate	Drug Derivative	Inflammation/Immunology
Sodium gualenate hydrate (Guaiazulenesulfonate sodium hydrate) is a derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis .

HY-W150752

Triphenylethylene	Estrogen Receptor/ERR Calcium Channel	Endocrinology
Triphenylethylene is an aromatic hydrocarbon that possesses weak estrogenic activity. Triphenylethylene antiestrogens relax duodenal intestinal muscle via a mechanism that involves inhibition of L-type Ca ²⁺ channels but not activation of K ⁺ channels .

HY-129471

Arbaprostil	Endogenous Metabolite	Inflammation/Immunology
Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect .

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra .

HY-P2703

Peptide YY (pig)	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system .

HY-W008614S

Lansoprazole sulfone-d4 AG-1813-d₄	Isotope-Labeled Compounds Proton Pump Drug Metabolite	Inflammation/Immunology
Lansoprazole sulfone (AG-1813)-d₄ is the deuterium labeled Lansoprazole sulfone (HY-W008614). Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H ⁺, K ⁺-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-126751

DBM-819	Na+/K+ ATPase	Metabolic Disease
DBM-819 is a reversible inhibitor of H⁺/K⁺-ATPase (H ⁺/K ⁺-ATPase), with an IC₅₀ value of 5 μM. DBM-819 can reversibly block gastric acid secretion by inhibiting the proton pump in the gastric mucosa. It shows significant protective effects against duodenal ulcers induced by Cysteamine (HY-77591), gastric ulcers induced by Indomethacin (HY-14397), and gastric ulcers induced by Aspirin (HY-14654), with EC₅₀ values of 6, 3.1, and 4 mg/kg respectively. DBM-819 can be used in ulcer prevention research .

HY-Z7660

Lansoprazole N-oxide	Drug Metabolite	Metabolic Disease Inflammation/Immunology
Lansoprazole N-oxide (Comound 2) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole N-oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome .

HY-Z7659

Lansoprazole sulfone N-Oxide	Drug Metabolite	Metabolic Disease Inflammation/Immunology
Lansoprazole sulfone N-Oxide (Comound 3) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole sulfone N-Oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome .

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-N10456

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone	Bacterial	Infection
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone is a potent antibacterial agent with an MIC₅₀ value of 22 µM and an MIC₉₀ value of 50 µM for Helicobacter pyloriStrain 51. 1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone has the potential for the research of gastric and duodenal ulcers .

HY-U00121A

Lintopride hydrochloride	5-HT Receptor	Metabolic Disease
Lintopride hydrochloride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride hydrochloride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride hydrochloride significantly increases the lower oesophageal sphincter (LOS) basal tone .

HY-B0305

Roxatidine acetate	Histamine Receptor	Metabolic Disease Inflammation/Immunology Cancer
Roxatidine acetate is a potent, selective, competitive and orally active histamine _H2-receptor antagonist. Roxatidine acetate has antisecretory potency against gastric acid secretion. Roxatidine acetate can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine acetate has antitumor activity .

HY-108515

(+)-Igmesine hydrochloride JO1784	Sigma Receptor NO Synthase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ₁ receptor ligand with an IC₅₀ of 39 nM. (+)-Igmesine hydrochloride binds σ₁ receptors to activate G-proteins and modulate Ca ²⁺ uptake. (+)-Igmesine (hydrochloride) attenuates ischaemia-induced nitric oxide synthase activity and hyperactivity. (+)-Igmesine hydrochloride can be used for the research of duodenal ulcers, gastric ulcers, and cerebral ischaemia .

HY-156973

Tiopropamine	Histamine Receptor	Inflammation/Immunology
Tiopropamine is an anti-inflammatory agent, with potential effect on histamine receptor .

HY-101234

ICI 162846	Histamine Receptor	Inflammation/Immunology
ICI 162846 is an orally active antagonist of H₂ receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU .

HY-134081

Desiodomethyl 4-DAMP	mAChR	Others
Desiodomethyl 4-DAMP is a muscarinic receptor antagonist .

HY-105651A

Butalamine hydrochloride	Cholinesterase (ChE)	Cardiovascular Disease
Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle .

HY-14289A

Cimetidine hydrochloride SKF-92334 hydrochloride	Histamine Receptor Bacterial	Metabolic Disease Cancer
Cimetidine (SKF-92334) hydrochloride is an orally active, inverse and BBB-permeable histamine H2 receptor antagonist with a K_i of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity .

HY-118546

JNJ-17156516	Cholecystokinin Receptor	Inflammation/Immunology
JNJ-17156516 is an orally active, potent, and selective cholecystokinin (CCK)1-receptor antagonist .

HY-126206

Quazodine MJ-1988	Phosphodiesterase (PDE)	Cardiovascular Disease
Quazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research .

HY-106323

[Leu13]-Motilin KW-5139	Motilin Receptor	Metabolic Disease
[Leu13]-Motilin (KW-5139) is a motilin analogue. [Leu13]-Motilin stimulates gastrointestinal motility in the rabbit. [Leu13]-Motilin causes concentration-dependent contractions of the gastric antrum, duodenum, jejunum, ileum and the descending colon in vitro .

HY-U00121

Lintopride	5-HT Receptor	Metabolic Disease
Lintopride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride significantly increases the lower oesophageal sphincter (LOS) basal tone .

HY-15541

Zaltidine CP-57361	Histamine Receptor	Endocrinology
Zaltidine dihydrochloride (CP-5736 dihydrochloride) is a highly specific H2 receptor antagonist with antisecretion activity. Zaltidine dihydrochloride reduces the stimulant effect of histamine on gastric acid secretion by binding to histamine H2 receptors on gastric parietal cells, thus reducing gastric acid production. Zaltidine dihydrochloride can be used in the study of gastric acid-related diseases such as duodenal ulcers .

HY-15541A

Zaltidine dihydrochloride CP-5736 dihydrochloride	Histamine Receptor	Endocrinology
Zaltidine (CP-5736) dihydrochloride is a highly specific H2 receptor antagonist with antisecretion activity. Zaltidine dihydrochloride reduces the stimulant effect of histamine on gastric acid secretion by binding to histamine H2 receptors on gastric parietal cells, thus reducing gastric acid production. Zaltidine dihydrochloride can be used in the study of gastric acid-related diseases such as duodenal ulcers .

HY-W008614S1

Lansoprazole sulfone-13C6 AG-1813-¹³C₆	Isotope-Labeled Compounds Proton Pump Drug Metabolite	Inflammation/Immunology
Lansoprazole sulfone (AG-1813)- ¹³C₆ is ¹³C labeled Lansoprazole sulfone (HY-W008614). Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H ⁺, K ⁺-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-14289AR

Cimetidine hydrochloride (Standard) SKF-92334 hydrochloride (Standard)	Reference Standards Histamine Receptor Bacterial	Endocrinology Cancer
Cimetidine (hydrochloride) (Standard) is the analytical standard of Cimetidine (hydrochloride). This product is intended for research and analytical applications. Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity .

HY-174547

Human PDX1 mRNA	mRNA	Metabolic Disease
Human PDX1 mRNA encodes the human pancreatic and duodenal homeobox 1 (PDX1) protein, a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. PDX1 may be involved in the early development of the pancreas. It also plays a major role in glucose-dependent regulation of insulin gene expression.

Cat. No.	Product Name	Target	Research Area

HY-P0093

Sincalide 4 Publications Verification Cholecystokinin octapeptide; CCK-8; SQ19844	Cholecystokinin Receptor Apoptosis PI3K Akt	Infection Cancer
Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-P0093A

Sincalide ammonium 4 Publications Verification Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium	Cholecystokinin Receptor Apoptosis PI3K Akt	Infection Cancer
Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK .

HY-P11292

Caloxin 1b3	Calcium Channel	Cardiovascular Disease
Caloxin 1b3, a peptide, is a selective plasma membrane Ca ²⁺ pump 1 (PMCA1) inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca ²⁺–Mg ²⁺-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca ²⁺ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research .

HY-109538

Secretin (swine)	Secretin Receptor	Neurological Disease Metabolic Disease
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism .

HY-P5390A

GIP, rat TFA	Peptides	Others
GIP, rat TFA is a bioactive peptide of rat origin. (GIP (glucose-dependent insulinotropic polypeptide or also known as gastric inhibitory polypeptide) is a 42-amino acid peptide released by K cells in the duodenum and jejunum in response to food intake. GIP and GLP (gastric-like peptide) are both intestinal A member of the insulinotropic hormone peptide family that stimulates insulin secretion from pancreatic beta cells and appears to also promote beta cell proliferation and beta cell survival. Recent studies suggest that GIP plays a role in lipid homeostasis and may play a role in the pathogenesis of obesity function in the mechanism.

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra .

HY-P2703

Peptide YY (pig)	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system .

HY-P5390

GIP, rat	Peptides	Others
GIP, rat is a biological active peptide. (GIP (Glucose-dependent Insulinotropic Polypeptide or also known as Gastric Inhibitory Polypeptide) is a 42-amino acid peptide released by the K cells of the duodenum and jejunum in response to food intake. GIP, together with GLP (Gastric-like Peptide) are members of the hormone peptide family of Incretins which stimulate insulin secretion from pancreatic islet β-cells, and also appears to promote beta cell proliferation and beta cell survival. Recent studies suggest that GIP plays a role in lipid homeostasis and possibly in the pathogenesis of obesity.)

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-106323

[Leu13]-Motilin KW-5139	Motilin Receptor	Metabolic Disease
[Leu13]-Motilin (KW-5139) is a motilin analogue. [Leu13]-Motilin stimulates gastrointestinal motility in the rabbit. [Leu13]-Motilin causes concentration-dependent contractions of the gastric antrum, duodenum, jejunum, ileum and the descending colon in vitro .

HY-109538R

Secretin (swine) (Standard)	Secretin Receptor Reference Standards	Neurological Disease Metabolic Disease
Secretin (swine) (Standard) is the analytical standard of Secretin (swine). This product is intended for research and analytical applications. Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism .

HY-P5495

Uroguanylin-15 (Rat)	Peptides	Others
Uroguanylin-15 (Rat) is a biological active peptide. (Uroguanylin is a natriuretic peptide, a hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. Uroguanylin and guanylin are related peptides that activate common guanylate cyclase signaling molecules in the intestine and kidney. Uroguanylin was isolated from urine and duodenum but was not detected in extracts from the colon of rats.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W983015

Davidigenin	Euphorbia portlandica L. Phenols Polyphenols Euphorbiaceae Plants Source Classification	5-HT Receptor
Davidigenin is an antidiabetic compound with antitumor, antispasmodic, and antioxidant activities. Davidigenin inhibits duodenal contractions induced by acetylcholine or histamine.

HY-N10456

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone	Natural Products Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley Source Classification	Bacterial
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone is a potent antibacterial agent with an MIC₅₀ value of 22 µM and an MIC₉₀ value of 50 µM for Helicobacter pyloriStrain 51. 1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone has the potential for the research of gastric and duodenal ulcers .

HY-N9554

WIN-64821	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Neurokinin Receptor Endogenous Metabolite Calcium Channel
WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The K_i values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca ²⁺ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research .

Cat. No.	Product Name	Chemical Structure

HY-W008614S

Lansoprazole sulfone-d4
Lansoprazole sulfone (AG-1813)-d₄ is the deuterium labeled Lansoprazole sulfone (HY-W008614). Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H ⁺, K ⁺-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-W008614S1

Lansoprazole sulfone-13C6
Lansoprazole sulfone (AG-1813)- ¹³C₆ is ¹³C labeled Lansoprazole sulfone (HY-W008614). Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H ⁺, K ⁺-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

Cat. No.	Product Name		Classification

HY-174547

Human PDX1 mRNA		mRNA Transcription Factors
Human PDX1 mRNA encodes the human pancreatic and duodenal homeobox 1 (PDX1) protein, a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. PDX1 may be involved in the early development of the pancreas. It also plays a major role in glucose-dependent regulation of insulin gene expression.

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duodenum

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