Oxyphenonium bromide
Based on 1 Customer Validation
Oxyphenonium bromide is an orally effective competitive muscarinic acetylcholine receptor (mAChR) antagonist. Oxyphenonium bromide competitively binds to and blocks mAChR, thereby inhibiting the parasympathetic pathway. By inhibiting CHRM4, Oxyphenonium bromide increases cAMP levels and activates the CREB transcriptional program, thereby promoting erythroid progenitor cell expansion. Oxyphenonium bromide can be used in research on asthma, anemia, and gastric ulcers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.39%
- CAS 番号: 50-10-2
- 分子式: C21H34BrNO3
- 分子量:428.40
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-B1719AR
Oxyphenonium bromide (Standard)Reference Standard -
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生物活性
製品説明
IC50 & Target
[1]|
mAChR4 |
体外実験
Oxyphenonium bromide (100 μM; 3-9 days) promotes long-term cell expansion, self-renewal, and colony formation in mouse early erythroid progenitor cells (BFU-E)[2].
Oxyphenonium bromide (100 μM; 45 min) increases phosphorylated CREB in mouse fetal liver BFU-Es[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Purified murine fetal liver BFU-E cells
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Concentration:100 µM
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Incubation Time:3, 6, 9 days
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Result:Induced long-term cell expansion and increased the formation of BFU-E colonies.
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Cell Line:Murine fetal liver BFU-E cells
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Concentration:100 µM
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Incubation Time:45 min
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Result:Significantly increased the nuclear staining intensity of p-CREB.
体内実験
Oxyphenonium bromide (25 mg/kg; i.p.; once daily; 45 days) corrects anemia and promotes BFU-E self-renewal in the Mx1-Cre Srsf2P95H/WT myelodysplastic syndrome (MDS) C57bl/6 mouse model[2].
Oxyphenonium bromide (21.4 mg/kg; s.c.; single administration; 15 min) inhibited the absorption rate of the radiopharmaceutical (DF32P) in a subcutaneous absorption model in albino mice[4].
Oxyphenonium bromide (0.4 mg/kg; i.v.; single administration; short-term observation) does not alter EEG activity and does not block amphetamine-induced EEG activation responses in the EEG activation model[5].
Oxyphenonium bromide (5 mg/kg; i.m.; twice daily; 7 and 14 days) reduces ulcer area, promotes epithelialization and collagen formation, and modulates enzyme activity in the ulcer region in a rat model of gastric ulcer[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (18- to 21-month-old male and female, aging model)[2]
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Dosage:25 mg/kg
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Administration:i.p.; once daily; 7 days
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Result:Alleviated anemia in 18- to 21-month-old aged mice, significantly increasing hematocrit (HCT) and hemoglobin (Hb) compared to the old + DMSO group.
Resulted in hemoglobin above the concentration in younger mice (median hemoglobin of 13.8 g/dl) in 25% of the aged mice, whereas vehicle treatment achieved this effect in 0% of aged mice.
Had no influence on EPO concentration.
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Animal Model:C57BL/6 (Mx1-Cre Srsf2P95H/WT MDS model; 8-week-old female recipients)[2]
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Dosage:25 mg/kg
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Administration:i.p.; once daily; 45 days
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Result:Corrected anemia of MDS, significantly increasing hematocrit (HCT) and hemoglobin (Hb) compared to the MDS + DMSO group.
Promoted BFU-E self-renewal.
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Animal Model:Albino mice (male, 25-30 g)[4]
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Dosage:21.4 mg/kg
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Administration:s.c.; single dose; 15 min
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Result:Reduced the activity in liver to 48% of control.
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Animal Model:Noninbred rats (160-200 g)[7]
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Dosage:5 mg/kg
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Administration:i.m.; twice a day; 7 and 14 days
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Result:Reduced the mean area of the ulcer to 69% of the control level on the 7th day.
Increased AlP activity by 132% and LDH activity by 31% in the region of the ulcer on the 14th day.\nWas less effective than KG-62 in accelerating healing of experimental gastric ulcers.
化学情報
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CAS 番号 50-10-2
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性状 Solid
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分子量 428.40
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分子式 C21H34BrNO3
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Color White to off-white
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SMILES
O=C(OCC[N+](CC)(CC)C)C(O)(C1CCCCC1)C2=CC=CC=C2.[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
H2O : 125 mg/mL (291.78 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (290 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.3343 mL | 11.6713 mL | 23.3427 mL | 58.3567 mL |
| 5 mM | 0.4669 mL | 2.3343 mL | 4.6685 mL | 11.6713 mL | |
| 10 mM | 0.2334 mL | 1.1671 mL | 2.3343 mL | 5.8357 mL | |
| 15 mM | 0.1556 mL | 0.7781 mL | 1.5562 mL | 3.8904 mL | |
| 20 mM | 0.1167 mL | 0.5836 mL | 1.1671 mL | 2.9178 mL | |
| 25 mM | 0.0934 mL | 0.4669 mL | 0.9337 mL | 2.3343 mL | |
| 30 mM | 0.0778 mL | 0.3890 mL | 0.7781 mL | 1.9452 mL | |
| 40 mM | 0.0584 mL | 0.2918 mL | 0.5836 mL | 1.4589 mL | |
| 50 mM | 0.0467 mL | 0.2334 mL | 0.4669 mL | 1.1671 mL | |
| 60 mM | 0.0389 mL | 0.1945 mL | 0.3890 mL | 0.9726 mL | |
| 80 mM | 0.0292 mL | 0.1459 mL | 0.2918 mL | 0.7295 mL | |
| 100 mM | 0.0233 mL | 0.1167 mL | 0.2334 mL | 0.5836 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Oxyphenonium bromide 関連分類
HY-B1719A 関連分類
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